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Cited by 100Spaceflight effects on biologyImmunotoxicology and immune responsesStress Responses and Cortisol

Towards human exploration of space: The THESEUS review series on immunology research priorities

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Frippiat, Jean-Pol, Crucian, Brian E, de Quervain, Dominique J-F, Grimm, Daniela, Montano, Nicola, Praun, Siegfried, Roozendaal, Benno, Schelling, Gustav +3 more·2016·npj Microgravity
DOI 10.1038/npjmgrav.2016.40PMC PMC5515533
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Abstract

Dysregulation of the immune system occurs during spaceflight and may represent a crew health risk during exploration missions because astronauts are challenged by many stressors. Therefore, it is crucial to understand the biology of immune modulation under spaceflight conditions in order to be able to maintain immune homeostasis under such challenges. In the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration, experts working in the field of space immunology, and related disciplines, established a questionnaire sent to scientists around the world. From the review of collected answers, they deduced a list of key issues and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space, and to increase increments duration for some ISS crew members to 12 months or longer. These recommendations should contribute to improve our knowledge about spaceflight effects on the immune system and the development of countermeasures that, beyond astronauts, could have a societal impact.

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References 97 · Cited by 100

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Authors
Frippiat, J.-P., Crucian, B. E., de Quervain, D. J.-F., Grimm, D., Montano, N., Praun, S., Roozendaal, B., Schelling, G., Thiel, M., Ullrich, O., & Choukèr, A.
Affiliations
  • Stress, IMmunité, PAthogènes (FR)
  • Johnson Space Center (US)
  • Aarhus University (DK)
  • University of Milan (IT)
  • Radboud University Nijmegen (NL)
  • Ludwig-Maximilians-Universität München (DE)
  • Heidelberg University (DE)
  • University of Zurich (CH)
Corresponding author
Frippiat, Jean-Pol
ORCID
Venue
npj Microgravity
Publisher
Springer Science and Business Media LLC
Published
2016-12-01
Volume
2
Issue
1
Pages
16040-16040
ISSN
2373-8065 (ISSN-L)
DOI
10.1038/npjmgrav.2016.40
PMC
PMC5515533
OpenAlex
W2560639677
Cited by
100
References
97
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 13 · 2020: 15 · 2019: 20 · 2018: 14 · 2017: 3
FWCI
1.45
Type
journal article
Language
en
Open access
Licence
Locations
  • npj Microgravity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
  • HAL (submittedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • National Aeronautics and Space Administration
  • Arizona State University
  • European Science Foundation
  • Centre National d’Etudes Spatiales
  • Biodesign Institute, Arizona State University
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
immune homeostasis, human space exploration, International Space Station crew, countermeasures, research priorities, astronaut health

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