The DOI matches its Crossref record; 357 of the 357 references it cites were found in a registry or an index.
Cognitive Control Deficits in Schizophrenia: Mechanisms and Meaning
Open accessAbstract
Although schizophrenia is an illness that has been historically characterized by the presence of positive symptomatology, decades of research highlight the importance of cognitive deficits in this disorder. This review proposes that the theoretical model of cognitive control, which is based on contemporary cognitive neuroscience, provides a unifying theory for the cognitive and neural abnormalities underlying higher cognitive dysfunction in schizophrenia. To support this model, we outline converging evidence from multiple modalities (eg, structural and functional neuroimaging, pharmacological data, and animal models) and samples (eg, clinical high risk, genetic high risk, first episode, and chronic subjects) to emphasize how dysfunction in cognitive control mechanisms supported by the prefrontal cortex contribute to the pathophysiology of higher cognitive deficits in schizophrenia. Our model provides a theoretical link between cellular abnormalities (eg, reductions in dentritic spines, interneuronal dysfunction), functional disturbances in local circuit function (eg, gamma abnormalities), altered inter-regional cortical connectivity, a range of higher cognitive deficits, and symptom presentation (eg, disorganization) in the disorder. Finally, we discuss recent advances in the neuropharmacology of cognition and how they can inform a targeted approach to the development of effective therapies for this disabling aspect of schizophrenia.
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Cites
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Self-citation
Cited by
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
Lewis, D. A., Curley, A. A., Glausier, J. R., & Volk, D. W. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.10.004 · Cited by 1,071
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Prefrontal–hippocampal interactions in episodic memory
Eichenbaum, H. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.74 · Cited by 870
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Cognition in schizophrenia: core psychological and neural mechanisms
Barch, D. M., & Ceaser, A. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.015 · Cited by 747
Metadata
- Authors
- Lesh, T. A., Niendam, T. A., Minzenberg, M. J., & Carter, C. S.
- Venue
- Neuropsychopharmacology
- Published
- 2010-09-15
- Volume
- 36
- Issue
- 1
- Pages
- 316-338
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2074397383
- Cited by
- 506
- References
- 357
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lesh, T. A., Niendam, T. A., Minzenberg, M. J., & Carter, C. S. (2011). Cognitive Control Deficits in Schizophrenia: Mechanisms and Meaning. Neuropsychopharmacology. https://doi.org/10.1038/npp.2010.156
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
