The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Peripubertal Diazepam Administration Prevents the Emergence of Dopamine System Hyperresponsivity in the MAM Developmental Disruption Model of Schizophrenia
Open accessAbstract
Schizophrenia is believed to arise from an interaction of genetic predisposition and adverse environmental factors, with stress being a primary variable. We propose that alleviating anxiety produced in response to stress during a sensitive developmental period may circumvent the dopamine (DA) system alterations that may correspond to psychosis in adults. This was tested in a developmental rat model of schizophrenia based on prenatal administration of the mitotoxin methyl azoxymethanol acetate (MAM). MAM administration leads to a hyperdopaminergic state consisting of an increase in the number of DA neurons firing spontaneously, which correlates with an increased behavioral response to amphetamine. MAM-treated rats exhibited a heightened level of anxiety during adolescence. Peripubertal administration of the antianxiety agent diazepam was found to prevent the increase in DA neuron activity and blunt the behavioral hyperresponsivity to amphetamine in these rats. These data suggest that the pathophysiological factors leading to the onset of psychosis in early adulthood may be circumvented by controlling the response to stress during the peripubertal period.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Consistent with this view, reducing stress sensitivity in juvenile MAM-treated rats with benzodiazepines prevents the abnormal increase in the activity of dopaminergic neurons and reduces hyperlocomotion in adult rats 71 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [71]
Citations
Cites
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356
Mapping the Onset of Psychosis: The Comprehensive Assessment of At-Risk Mental States
Yung, A. R., Yung, A. R., Yuen, H. P., McGorry, P. D., Phillips, L., Kelly, D., Dell’Olio, M., Francey, S. M., Cosgrave, E., Killackey, E. J., et al. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01714.x · Cited by 2,284
Miller, T. J., McGlashan, T. H., Rosen, J. L., Cadenhead, K. S., Ventura, J., McFarlane, W. R., Perkins, D. O., Pearlson, G. D., & Woods, S. W. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007040 · Cited by 1,800
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
Lewis, D. A., Curley, A. A., Glausier, J. R., & Volk, D. W. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.10.004 · Cited by 1,071
Grace, A. A., & Bunney, B. S. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90135-5 · Cited by 937
Self-citationSchizophrenia: A neural diathesis-stress model.
Walker, E. F., & Diforio, D. (1997) · Psychological Review · doi:10.1037//0033-295x.104.4.667 · Cited by 930
Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00259-l · Cited by 863
Hippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging
Nelson, M. D., Saykin, A. J., Flashman, L. A., & Riordan, H. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.5.433 · Cited by 756
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–105 of 105
Fabris, D., Andrade, L. M., Freitas, I. D. S., Gomes, F. V., & Guimarães, F. S. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.10.012
Diazepam modulates anterior cingulate glutamate levels in people at clinical high-risk for psychosis
Kiemes, A., Livingston, N. R., Lukow, P. B., Knight, S., Jelen, L. A., Reilly, T. J., Dima, A., Nettis, M. A., Lythgoe, D. J., Casetta, C., et al. (2025) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaf078
Self-citationWang, S., Yu, M., He, Y., Wang, D., Liu, K., & Xiang, B. (2026) · Child Psychiatry & Human Development · doi:10.1007/s10578-026-02018-2
Lee, T. Y., Eom, K., Kim, J. J., Lee, Y., & Hyun, J. H. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.06.029
Metadata
- Authors
- Du, Y., & Grace, A. A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Du, Yijuan
- Venue
- Neuropsychopharmacology
- Published
- 2013-04-23
- Volume
- 38
- Issue
- 10
- Pages
- 1881-1888
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3746684
- OpenAlex
- W1970236655
- Cited by
- 105
- References
- 56
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 10 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 6 · 2014: 5 · 2013: 4
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01mh057440-26a1)
- National Institute of Mental Health (MH-57440, R01-MH057440, R37MH057440)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- schizophrenia, methylazoxymethanol acetate, diazepam, peripubertal period, anxiety, stress, amphetamine response, psychosis prevention, rat model
- MeSH terms
- Amphetamine, Animals, Anxiety, Diazepam, Female, Male, Methylazoxymethanol Acetate, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Ventral Tegmental Area, Maze Learning, Rats, Dopaminergic Neurons, Central Nervous System Sensitization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
