A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Abstract
In recent years, great strides have been made in our understanding of how stem cells (SCs) govern tissue homeostasis and regeneration. The inherent longevity of SCs raises the possibility that the unique protective mechanisms in these cells might also be involved in tumorigenesis. In this Opinion article, we discuss how SCs are protected throughout their lifespan, focusing on quiescent behaviour, DNA damage response and programmed cell death. We briefly examine the roles of adult SCs and progenitors in tissue repair and tumorigenesis and explore how signals released from dying or dormant cells influence the function of healthy or aberrant SCs. Important insight into the mechanisms that regulate SC death and survival, as well as the 'legacy' imparted by departing cells, may unlock novel avenues for regenerative medicine and cancer therapy.
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The SG has been proposed to be replenished by distinct pools of stem cells or progenitors located in the HF or base of the SG.
“The SG has been proposed to be replenished by distinct pools of stem cells or progenitors located in the HF or base of the SG3–7.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [4]
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References 193 · Cited by 87
- Authors
- Soteriou, D., & Fuchs, Y.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Fuchs, Yaron
- Venue
- Nature Reviews Cancer
- Published
- 2018-01-19
- Volume
- 18
- Issue
- 3
- Pages
- 187-201
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2783721414
- Cited by
- 87
- References
- 193
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 12 · 2019: 16 · 2018: 10
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- stem cell survival, stem cell quiescence, DNA damage response, apoptosis, tissue regeneration, carcinogenesis, cancer stem cells, tissue homeostasis, adult stem cells, progenitor cells, regenerative medicine, cancer therapy
- MeSH terms
- Animals, Cell Survival, DNA Repair, Drosophila melanogaster, Humans, Intestinal Neoplasms, Neoplasms, Regeneration, Skin Neoplasms, Stem Cells, Neoplastic Stem Cells, Wound Healing, Apoptosis, Cell Proliferation
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