A census of human cancer genes

The Pfam Protein Families Database

Bateman, A. G. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,075

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., et al. (1998) · Science · doi:10.1126/science.279.5350.577 · Cited by 4,487

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,884

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785

A cell cycle regulator potentially involved in genesis of many tumor types

Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751

PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

Heinrich, M. C., Corless, C. L., Duensing, A. U., McGreevey, L. S., Chen, C.-J., Joseph, N. E., Singer, S., Griffith, D., Haley, A., Town, A., et al. (2003) · Science · doi:10.1126/science.1079666 · Cited by 2,297

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R. E., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nyström, M., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90330-s · Cited by 2,271

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. W., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,992

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

Hemminki, A., Markie, D., Tomlinson, I. P. M., Avizienyte, E., Roth, S., Loukola, A., Bignell, G. R., Warren, W., Aminoff, M., Höglund, P., et al. (1998) · Nature · doi:10.1038/34432 · Cited by 1,680

The roles of FLT3 in hematopoiesis and leukemia

Gilliland, D. G., & Griffin, J. D. (2002) · Blood · doi:10.1182/blood-2002-02-0492 · Cited by 1,611

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

Kane, M., Loda, M. F., Gaida, G. M., Lipman, J., Mishra, R., Goldman, H., Jessup, J. M., & Kolodner, R. D. (1997) · PubMed · Cited by 1,476

Mechanism of activation of a human oncogene

Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

Reddy, E. P., Reynolds, R. K., Santos, E., & Barbacid, M. (1982) · Nature · doi:10.1038/300149a0 · Cited by 1,391

BRCA1 mutations in primary breast and ovarian carcinomas.

Futreal, P., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L., Haugen-Strano, A., Swensen, J., & Miki, Y. (1994) · Science · doi:10.1126/science.7939630 · Cited by 1,378

Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex

Kirschner, L. S., Carney, J. A., Pack, S. D., Taymans, S. E., Giatzakis, C., Cho, Y. S., Cho-Chung, Y. S., & Stratakis, C. A. (2000) · Nature Genetics · doi:10.1038/79238 · Cited by 1,153

Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

The CHEK2-Breast Cancer Consortium (2002) · Nature Genetics · doi:10.1038/ng879 · Cited by 1,104

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

Baker, S. J., Preisinger, A. C., Jessup, J. M., Paraskeva, C., Markowitz, S. D., Willson, J. K. V., Hamilton, S. R., & Vogelstein, B. (1990) · PubMed · Cited by 1,065

Hypermutability and mismatch repair deficiency in RER+ tumor cells

Parsons, R. E., Li, G., Longley, M. J., Fang, W.-H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B., & Modrich, P. L. (1993) · Cell · doi:10.1016/0092-8674(93)90331-j · Cited by 1,054

The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers

Ohta, M., Inoue, H., Cotticelli, M. G., Kastury, K., Baffa, R., Palazzo, J., Siprashvili, Z., Mori, M., McCue, P. A., Druck, T., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81034-x · Cited by 978

Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma

Tognon, C. E., Knezevich, S. R., Huntsman, D. D., Roskelley, C. D., Melnyk, N., Mathers, J. A., Becker, L. E., Carneiro, F., Macpherson, N. A., Horsman, D. E., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00180-0 · Cited by 908

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

Wong, A. J., Ruppert, J. M., Bigner, S. H., Grzeschik, C. H., Humphrey, P. A., Bigner, D. S., & Vogelstein, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.2965 · Cited by 851

PAX8-PPAR γ 1 Fusion in Oncogene Human Thyroid Carcinoma

Kroll, T. G., Sarraf, P., Pecciarini, L., Chen, C., Mueller, E., Spiegelman, B. M., & Fletcher, J. A. (2000) · Science · doi:10.1126/science.289.5483.1357 · Cited by 780

The Pfam Protein Families Database

Bateman, A. G., Birney, E., Cerruti, L., Durbin, R. M., Etwiller, L., Eddy, S. R., Griffiths‐Jones, S., Howe, K., Marshall, M. S., & Sonnhammer, E. L. L. (2002) · PubMed Central · Cited by 764

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC

Laken, S. J., Petersen, G. M., Gruber, S. B., Oddoux, C., D, H. O. M., Giardiello, F. M., Hamilton, S. R., Hampel, H., Markowitz, A. J., Klimstra, D. S., et al. (1997) · Nature Genetics · doi:10.1038/ng0997-79 · Cited by 676

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis

Howe, J. R., Bair, J. L., Sayed, M. G., Anderson, M. E., Mitros, F. A., Petersen, G. M., Velculescu, V. E., Traverso, G., & Vogelstein, B. (2001) · Nature Genetics · doi:10.1038/88919 · Cited by 630

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.

Sánchez‐Céspedes, M., Parrella, P., Esteller, M., Nomoto, S., Trink, B., Engles, J. M., Westra, W. H., Herman, J. G., & Sidransky, D. (2002) · PubMed · Cited by 626

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

Ayton, P. M., & Cleary, M. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204639 · Cited by 503

RET/PTC Rearrangement in Thyroid Tumors

Nikiforov, Y. E. (2002) · Endocrine Pathology · doi:10.1385/ep:13:1:03 · Cited by 491

Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.

Shih, C., Shilo, B., Goldfarb, M. P., Dannenberg, A. J., & Weinberg, R. A. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5714 · Cited by 487

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.

Bednarek, A. K., Laflin, K. J., DANIEL, R. L., Liao, Q., Hawkins, K. A., & Aldaz, C. M. (2000) · PubMed · Cited by 420

Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability.

Duval, A., & Hamelin, R. (2002) · PubMed · Cited by 398

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

Grady, W. M., Myeroff, L. L., Swinler, S. E., Rajput, A., Thiagalingam, S., Lutterbaugh, J., Neumann, A., Brattain, M. G., Chang, J., Kim, S., et al. (1999) · PubMed · Cited by 391

Transforming activity of human tumor DNAs.

Krontiris, T. G., & Cooper, G. M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.2.1181 · Cited by 373

BRCA2 mutations in primary breast and ovarian cancers

Lancaster, J. M., Wooster, R., Mangion, J., Phelan, C. M., Cochran, C., Gumbs, C. E., Seal, S., Barfoot, R., Collins, N., Bignell, G. R., et al. (1996) · Nature Genetics · doi:10.1038/ng0696-238 · Cited by 360

Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

Zhuang, Z., Park, W.-S., Pack, S., Schmidt, L. S., Vortmeyer, A. O., Pak, E. D., Pham, T., Weil, R. J., Candidus, S., Lubensky, I. A., et al. (1998) · Nature Genetics · doi:10.1038/1727 · Cited by 290

Altered methylation patterns in cancer cell genomes: Cause or consequence?

Baylin, S. B., & Bestor, T. H. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00061-2 · Cited by 278

The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene

Sidhar, S. K. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.9.1333 · Cited by 266

Molecular Characterization of a Thyroid Tumor-Specific Transforming Sequence Formed by the Fusion of ret Tyrosine Kinase and the Regulatory Subunit RIα of Cyclic AMP-Dependent Protein Kinase A

Bongarzone, I., Monzini, N., Borrello, M. G., Carcano, C., Ferraresi, G., Arighi, E., Mondellini, P., Porta, G., & Pierotti, M. A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.358-366.1993 · Cited by 254

Germline p53 Mutations in a Cohort with Childhood Sarcoma: Sex Differences in Cancer Risk

Hwang, S., Lozano, G., Amos, C. I., & Strong, L. C. (2003) · The American Journal of Human Genetics · doi:10.1086/374567 · Cited by 229

Fragile sites still breaking

Sutherland, G. R., Baker, E., & Richards, R. I. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01628-x · Cited by 174

Evolution of instability at coding and non-coding repeat sequences in human MSI-H colorectal cancers

Duval, A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.513 · Cited by 120

Two new recurrent nucleotide mutations in the COL1A1 gene in four patients with osteogenesis imperfecta: About one‐fifth are recurrent

Körkkö, J., Kuivaniemi, H., Paassilta, P., Zhuang, J., Tromp, G., DePaepe, A., Prockop, D. J., & Ala‐Kokko, L. (1997) · Human Mutation · doi:10.1002/(sici)1098-1004(1997)9:2 · Cited by 23

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011) · Cell · doi:10.1016/j.cell.2011.07.014 · Cited by 7,262

U1 snRNP regulates cancer cell migration and invasion in vitro

Oh, J.-M., Venters, C. C., Di, C., Pinto, A. M., Wan, L., Younis, I., Cai, Z., Arai, C., So, B. R., Duan, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13993-7 · Cited by 7,157

COSMIC: the Catalogue Of Somatic Mutations In Cancer

Tate, J. G., Bamford, S., Jubb, H. C., Sondka, Z., Beare, D. M., Bindal, N., Boutselakis, H., Cole, C. G., Creatore, C., Dawson, E., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1015 · Cited by 4,867

Neoantigens in cancer immunotherapy

Schumacher, T. N., & Schreiber, R. D. (2015) · Science · doi:10.1126/science.aaa4971 · Cited by 4,783

Systematic analyses of the cancer genome: lessons learned from sequencing most of the annotated human protein-coding genes

Sjöblom, T. (2008) · Current Opinion in Oncology · doi:10.1097/cco.0b013e3282f31108 · Cited by 27

Abstract 2469: The COSMIC Cancer Gene Census - a comprehensive study of all mutated cancer-driving genes

Sońdka, Z., Speedy, H. E., Bamford, S., Cole, C. G., Ward, S. A., & Forbes, S. A. (2019) · Cancer Research · doi:10.1158/1538-7445.am2019-2469 · Cited by 1

Patterns of somatic mutation in human cancer genomes

Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,143

Identification of cancer genes by mutational profiling of tumor genomes

Benvenuti, S., Arena, S., & Bardelli, A. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.02.015 · Cited by 26

[Genes associated to cancer].

Peralta-Rodríguez, R., Valdivia, A., Mendoza, M. C., de Rodríguez, J., Marrero–Rodríguez, D., Paniagua, L., Romero, P., Taniguchi, K., & Salcedo, M. (2015) · PubMed · Cited by 2