The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Telomerase and cancer therapeutics
Abstract
Telomerase is an attractive cancer target as it appears to be required in essentially all tumours for immortalization of a subset of cells, including cancer stem cells. Moreover, differences in telomerase expression, telomere length and cell kinetics between normal and tumour tissues suggest that targeting telomerase would be relatively safe. Clinical trials are ongoing with a potent and specific telomerase inhibitor, GRN163L, and with several versions of telomerase therapeutic vaccines. The prospect of adding telomerase-based therapies to the growing list of new anticancer products is promising, but what are the advantages and limitations of different approaches, and which patients are the most likely to respond?
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In the citing paper
“The demonstration that dysfunctional telomeres could engage a senescence program to suppress tumorigenesis in vivo suggests possible future therapeutic applications63.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [63]
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1 retracted
Akiyama, M., Hideshima, T., Shammas, M. A., Hayashi, T., Hamasaki, M., Tai, Y., Richardson, P. G. G., Gryaznov, S. M., Munshi, N. C., & Anderson, K. C. (2003) · PubMed · Cited by 84
RetractedHanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Self-citationTelomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Self-citationIdentification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917
A survey of telomerase activity in human cancer
Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280
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Research works printed but not linked: 1
- Dikmen, Z. et al. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res. 7866–7873 (2005). · DOI · Paper page
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Principles of cancer therapy: oncogene and non-oncogene addiction
Luo, J., Solimini, N. L., & Elledge, S. J. (2009) · Cell · doi:10.1016/j.cell.2009.02.024 · Cited by 1,765
He, C., Liu, D., & Lin, W. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00125 · Cited by 1,011
Wang (2012) · doi:10.1161/circresaha.111.261388 · Cited by 957
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
Totoki, Y., Tatsuno, K., Covington, K. R., Ueda, H., Creighton, C. J., Kato, M., Tsuji, S., Donehower, L. A., Slagle, B. L., Nakamura, H., et al. (2014) · Nature Genetics · doi:10.1038/ng.3126 · Cited by 781
Role of Telomeres and Telomerase in Aging and Cancer
Shay, J. W. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0062 · Cited by 668
Metadata
- Authors
- Harley, C. B.
- Affiliations
- Geron (United States) (US)
- Corresponding author
- Harley, Calvin B.
- Venue
- Nature Reviews Cancer
- Published
- 2008-03
- Volume
- 8
- Issue
- 3
- Pages
- 167-179
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2078805336
- Cited by
- 728
- References
- 147
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 26 · 2023: 39 · 2022: 20 · 2021: 29 · 2020: 38 · 2019: 39 · 2018: 27 · 2017: 38 · 2016: 48 · 2015: 58 · 2014: 48 · 2013: 51 · 2012: 53
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- telomerase, telomerase inhibitors, GRN163L, cancer therapeutics, cancer stem cells, telomere length, cell kinetics, anticancer drug development
- MeSH terms
- Antineoplastic Agents, Clinical Trials as Topic, Enzyme Inhibitors, Humans, Immunotherapy, Kinetics, Medical Oncology, Models, Biological, Neoplasms, Oligonucleotides, Oligopeptides, Gene Expression Regulation, Neoplastic, Telomerase, Cancer Vaccines
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