Hypoxia, DNA repair and genetic instability

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Items 701–800 of 1,000

1. Fractionation in prostate cancer – Is it time after all?
   Michael A. Baumann, Tobias Hölscher, James William Denham · 2010 · Radiotherapy and Oncology
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   Katsuyuki Takahashi, Masako Tanaka, Masakazu Yashiro, Masaki Matsumoto, Asuka Ohtsuka, Keiichi I. Nakayama, Yasukatsu Izumi, Katsuya Nagayama, Katsuyuki Miura, Hiroshi Iwao et al. · 2016 · Cancer Letters
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4. Together Intra-Tumor Hypoxia and Macrophagic Immunity Are Driven Worst Outcome in Pediatric High-Grade Osteosarcomas
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5. XRCC1 R399Q polymorphism and colorectal cancer risk in the Chinese Han population: a meta-analysis
   Changjiang Qin, Kaiwu Xu, Zhihui Chen, Ertao Zhai, Yulong He, Xinming Song · 2015 · Tumor Biology
6. Mitochondrial creatine kinase 1 in non-small cell lung cancer progression and hypoxia adaptation
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7. Nitric oxide nano-prodrug platform with synchronous glutathione depletion and hypoxia relief for enhanced photodynamic cancer therapy
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10. Programming of the glucose metabolism in rainbow trout juveniles after chronic hypoxia at hatching stage combined with a high dietary carbohydrate: Protein ratios intake at first-feeding
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13. Therapeutic Landscape of Malignant Pleural Mesothelioma: Collateral Vulnerabilities and Evolutionary Dependencies in the Spotlight
    Duo Xu, Haitang Yang, Ralph Alexander Schmid, Ren‐Wang Peng · 2020 · Frontiers in Oncology
14. Effects of hypoxia on DNA hydroxymethylase Tet methylcytosine dioxygenase 2 in a KG‑1 human acute myeloid leukemia cell line and its mechanism
    Ping He, Jian Lei, Li-Xin Zou, Guizhen Zhou, Lang Peng, Qian Deng, Xiaoliu Liu · 2021 · Oncology Letters
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17. A smart tumor-microenvironment responsive nanoprobe for highly selective and efficient combination therapy
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18. Targeting DNA repair pathways: mechanisms and potential applications in cancer therapy
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19. Oral biomaterials for intestinal regulation
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22. Evolutionary determinants of curability in cancer
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23. Long-term interferon-α treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma
    Peng–Yuan Zhuang, Jubo Zhang, Wei Zhang, Xiao‐Dong Zhu, Ying Jie Liang, Huaxiang Xu, Yuquan Xiong, Ling–Qun Kong, Lu Wang, Wei‐Zhong Wu et al. · 2010 · Journal of Cancer Research and Clinical Oncology
24. Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis
    E.-Y. So, M Ausman, Toshiaki Saeki, Toru Ouchi · 2011 · Cell Death and Disease
25. Pilot study of PET imaging of 124I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer
    Joseph A. O’Donoghue, José G. Guillem, Heiko M. Schöder, Nancy Y. Lee, Chaitanya R. Divgi, Jeannine A. Ruby, John Laurence Humm, Steven A. Lee-Kong, Eva M. Burnazi, Shangde Cai et al. · 2013 · EJNMMI Research
26. Radiation Modifiers
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27. Study of Transcriptomic Analysis of Yak (Bos grunniens) and Cattle (Bos taurus) Pulmonary Artery Smooth Muscle Cells under Oxygen Concentration Gradients and Differences in Their Lung Histology and Expression of Pyruvate Dehydrogenase Kinase 1-Related Factors
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28. Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance
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29. Modelling radiobiology
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30. Dynamic scenario of metabolic pathway adaptation in tumors and therapeutic approach
    Silvia Peppicelli, Francesca Bianchini, Lido Calorini · 2015 · Oncoscience
31. Development and Validation of a Novel Hypoxia-Related Long Noncoding RNA Model With Regard to Prognosis and Immune Features in Breast Cancer
    Peng Gu, Lei Zhang, Ruitao Wang, Wentao Ding, Wei Wang, Yuan Liu, Wenhao Wang, Zuyin Li, Bin Yan, Xing Sun · 2021 · Frontiers in Cell and Developmental Biology
32. Mechanism of N-Methyl-N-Nitroso-Urea-Induced Gastric Precancerous Lesions in Mice
    Sheng-Xiong Zhang, Wen Tian, Yuanliang Liu, Jia-Hui Ni, Dan Zhang, Huafeng Pan, Ziming Zhao, Bo Ai, Zhe‐Sheng Chen, Lizhu Lin et al. · 2022 · Journal of Oncology
33. Identification and validation of a prognostic signature related to hypoxic tumor microenvironment in cervical cancer
    Chenyu Nie, Haixia Qin, Li Zhang · 2022 · PLoS ONE
34. Convergent TP53 loss and evolvability in cancer
    Marcela Braga Mansur, Melvyn F. Greaves · 2023 · BMC Ecology and Evolution
35. N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)
    Yan Song, Lili Cao · 2013 · Oncology Letters
36. Facile Preparation of Macromolecular Prodrugs for Hypoxia-Specific Chemotherapy
    Jianyang Zhao, Diana Diaz‐Dussan, Zhiqiang Jiang, Yi‐Yang Peng, John White, Wei Duan, Ravin Narain, Xiaojuan Hao, Lingxue Kong · 2020 · ACS Macro Letters
37. Advances in Cancer Stem Cell Biology
    Roberto Scatena, Bruno Giardina, Alvaro Mordente · 2011 · Springer eBooks
38. Phenotype-dependent production of des-γ-carboxy prothrombin in hepatocellular carcinoma
    Hideto Suzuki, Kazumoto Murata, Takaya Gotoh, Masao Kusano, Hiroshi Okano, Takashi Oyamada, Yoshikazu Yasuda, Masatoshi Imamura, Masatoshi Kudo, Masashi Mizokami et al. · 2011 · Journal of Gastroenterology
39. Sensitivity to chemoradiation predicts development of metastasis in muscle-invasive bladder cancer patients
    Fumitaka Koga, Noboru Numao, Kazutaka Saito, Hitoshi Masuda, Yasuhisa Fujii, Satoru Kawakami, Kazunori Kihara · 2012 · Urologic Oncology Seminars and Original Investigations
40. 1,2‐Bis(methylsulfonyl)‐1‐(2‐chloroethyl)‐2‐[[1‐(4‐nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a Cytotoxic Prodrug with Two Stable Conformations Differing in Biological and Physical Properties
    Philip G. Penketh, Raymond P. Baumann, Krishnamurthy Shyam, Hugh S. Williamson, Kimiko Ishiguro, Rui Zhu, Emma S. E. Eriksson, Leif Axel Eriksson, Alan C. Sartorelli · 2011 · Chemical Biology & Drug Design
41. Metal-phenolic networks specifically eliminate hypoxic tumors by instigating oxidative and proteotoxic stresses
    Jia Liu, Zuoyu Chen, Lixue Deng, Chundong Yao, Zhixin Zhou, Cheng Zhou, Yawen Bin, Miao‐Deng Liu, Liping Wang, Lin Wang et al. · 2025 · Bioactive Materials
42. Exploring the role of ferroptosis in esophageal cancer: mechanisms and therapeutic implications
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43. Maternally inherited susceptibility to cancer
    M. Pilar Bayona‐Bafaluy, Ester López‐Gallardo, Julio Montoya, Eduardo Ruiz‐Pesini · 2010 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
44. Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions
    Hideaki Nakamura, Hidemasa U. Bono, Keiko Hiyama, Takeshi Kawamoto, Yukio Kato, Takeshi Nakanishi, Masahiko Nishiyama, Eiso Hiyama, Nobuyuki Hirohashi, Eisaburo Sueoka et al. · 2018 · PLoS ONE
45. Incidence and Impact of Pretreatment Tumor Cavitation on Survival Outcomes of Stage III Squamous Cell Lung Cancer Patients Treated With Radical Concurrent Chemoradiation Therapy
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46. Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance
    Mohammud Shakeel Inder, Mark Bates, N. Ní Labhraí, Niamh McDermott, Julia A. Schneider, Gerrit Erdmann, Taylor A. Jamerson, Victoria Anastasia Belle, Adriele Prina‐Mello, Pierre Guillame Thirion et al. · 2019 · Scientific Reports
47. Metal substrate catalysis in the confined space for platinum drug delivery
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48. Targeting DNA topoisomerase IIα ( TOP2A ) in the hypoxic tumour microenvironment using unidirectional hypoxia‐activated prodrugs ( uHAPs )
    Paul J. Smith, STEPHANIE R. McKEOWN, Laurence H. Patterson · 2022 · IUBMB Life
49. Cancer stem cells may be mostly maintained by fluctuating hypoxia
    Qingjia Sun, Xiaoming Li, Xiuying Lu, Bin Di · 2010 · Medical Hypotheses
50. Hypoxia Integration in the Serological Proteome Analysis Unmasks Tumor Antigens and Fosters the Identification of Anti-Phospho-eEF2 Antibodies as Potential Cancer Biomarkers
    Marie M. Grandjean, Alexandra B.L. Sermeus, Samuel Branders, Florence Defresne, Marc Dieu, Pierre Dupont, Martine J. Raes, Mark De Ridder, Olivier Féron · 2013 · PLoS ONE
51. Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax
    Vered Domankevich, Yarden Opatowsky, Assaf Malik, Abraham B. Korol, Zeev Frenkel, Irena Manov, Aaron Avivi, Imad Shams · 2016 · BMC Evolutionary Biology
52. Antagonism in effectiveness of evofosfamide and doxorubicin through intermolecular electron transfer
    Robert F. Anderson, Dan Li, Francis W. Hunter · 2017 · Free Radical Biology and Medicine
53. Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas
    Karuna Mittal, Da Hoon Choi, Guanhao Wei, Jaspreet Singh Kaur, Sergey Klimov, Komal Arora, Christopher C. Griffith, Mukesh Kumar, Precious Imhansi-Jacob, Brian D. Melton et al. · 2020 · Cancers
54. PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling
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55. Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells
    Ramya Kumareswaran, Naz Chaudary, Karolina Jaluba, Alice X. Meng, Jenna R. Sykes, Sayem Borhan, Richard Peter Hill, Robert Glen Bristow · 2015 · Radiotherapy and Oncology
56. Differential effects of hypoxia and acidosis on p53 expression, repair of UVC-damaged DNA and viability after UVC in normal and tumor-derived human cells
    Diana Dregoesc, Andrew J. Rainbow · 2009 · DNA repair
57. XRCC1 polymorphisms and lung cancer risk in Caucasian populations: a meta-analysis.
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58. Theoretical study on the photophysical properties of thiophene-fused-type BODIPY series molecules in fluorescence imaging and photodynamic therapy
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59. A Pyroptosis Radiosensitizer Facilitates Hypoxic Tumor Necrosis
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60. Application of bifidobacterium in tumor therapy
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61. Engineering Multi-Functional Enzyme-Mimetic Polyphenol-Catalase Complex for Reversing Hypoxia and Redox Homeostasis in Vascular and Muscular Regeneration
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62. p53 activated by AND gate genetic circuit under radiation and hypoxia for targeted cancer gene therapy
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63. An Immunohistochemical Study of the Expression of the Hypoxia Markers Glut-1 and Ca-IX in Canine Sarcomas
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64. Investigating the role of functional imaging in the management of soft-tissue sarcomas of the extremities
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65. Gene expression profiling and clinical relevance unravel the role hypoxia and immune signaling genes and pathways in breast cancer
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66. N-VEGF, the Autoregulatory Arm of VEGF-A
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68. Affinely adjustable robust optimization for radiation therapy under evolving data uncertainty via semi-definite programming
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69. Regulation of early diagnosis and prognostic markers of lung adenocarcinoma in immunity and hypoxia
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70. In situ hypoxia modulating nano-catalase for amplifying DNA damage in radiation resistive colon tumors
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71. A GdW10@PDA-CAT Sensitizer with High-Z Effect and Self-Supplied Oxygen for Hypoxic-Tumor Radiotherapy
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72. Elevated DNA damage response in pancreatic cancer
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73. Differentiation in Neuroblastoma: Diffusion-Limited Hypoxia Induces Neuro-Endocrine Secretory Protein 55 and Other Markers of a Chromaffin Phenotype
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74. Transcriptional Regulation of the Human Genes that Encode DNA Repair- and Mitochondrial Function-Associated Proteins
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75. Radiosensitizing effects of Sestrin2 in PC3 prostate cancer cells.
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76. Metabolic stress in space: ROS-induced mutations in mice hint at a new path to cancer
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77. Engineering Tools for Regulating Hypoxia in Tumour Models
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78. Molecular chaperones in DNA repair mechanisms: Role in genomic instability and proteostasis in cancer
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79. Metal–Organic Framework-Derived Multifunctional Nucleic Acid Nanoprobes for Hypoxia Imaging-Guided Radiosensitization
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81. XRCC1 Arg399Gln polymorphism contributes to increased risk of colorectal cancer in Chinese population
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82. The Efficacy of CHK1 Inhibitors Is Not Altered by Hypoxia, but Is Enhanced after Reoxygenation
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83. Mathematical modeling of tumor response to radiation: radio-sensitivity correlation with BOLD, TOLD, ΔR1 and ΔR2* investigated in large Dunning R3327-AT1 rat prostate tumors
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84. Survival and central photopenia detected by fluorine-18 fluoro-deoxy-glucose positron emission tomography (FDG-PET) in patients with locoregional non-small cell lung cancer treated with radiotherapy
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85. The unidirectional hypoxia‐activated prodrug OCT1002 inhibits growth and vascular development in castrate‐resistant prostate tumors
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86. Large scale in vivo micro‐RNA loss of function screen identified miR‐29a, miR‐100 and miR‐155 as modulators of radioresistance and tumor‐stroma communication
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87. Yttrium-90 Radioembolization and Tumor Hypoxia: Gas-challenge BOLD Imaging in the VX2 Rabbit Model of Hepatocellular Carcinoma
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88. Aberrant methylation of GADD45A is associated with decreased radiosensitivity in cervical cancer through the PI3K/AKT signaling pathway
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89. Incidence of the CHEK2 Germline Mutation and Its Impact on Clinicopathological Features, Treatment Responses, and Disease Course in Patients with Papillary Thyroid Carcinoma
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90. 8DEstablishment and validation of a hypoxia-related signature predicting prognosis in hepatocellular carcinoma
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91. Development of an automated production process of [64Cu][Cu (ATSM)] for positron emission tomography imaging and theranostic applications
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92. Inverse Relationship Between Biochemical Outcome and Acute Toxicity After Image-Guided Radiotherapy for Prostate Cancer
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93. Breast cancer causes and treatment: where are we going wrong?
    Colin B Seymour, Carmel E Mothersill · 2013 · Breast Cancer Targets and Therapy
94. Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells
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95. Malignant Mesothelioma
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96. Tumor senescence and radioresistant tumor-initiating cells (TICs): let sleeping dogs lie!
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97. The biological role of extracellular vesicles in gastric cancer metastasis
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98. Radionuclide-labeled nanomaterials for tumor therapy: Recent progress and perspectives
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99. Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia
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100. Guiqi Baizhu decoction enhances radiosensitivity in non-small cell lung cancer by inhibiting the HIF-1α/DNA-PKcs axis-mediated DNA repair
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