Wnt signalling and its impact on development and cancer
Abstract
The Wnt signalling pathway is an ancient system that has been highly conserved during evolution. It has a crucial role in the embryonic development of all animal species, in the regeneration of tissues in adult organisms and in many other processes. Mutations or deregulated expression of components of the Wnt pathway can induce disease, most importantly cancer. The first gene to be identified that encodes a Wnt signalling component, Int1 (integration 1), was molecularly characterized from mouse tumour cells 25 years ago. In parallel, the homologous gene Wingless in Drosophila melanogaster, which produces developmental defects in embryos, was characterized. Since then, further components of the Wnt pathway have been identified and their epistatic relationships have been defined. This article is a Timeline of crucial discoveries about the components and functions of this essential pathway.
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All efforts to develop and translate effective and safe Wnt-pathway modulators into the clinical setting have been complicated by the multifaceted nature of Wnt-signaling.
“However, all efforts to develop and translate effective and safe Wnt-pathway modulators into the clinical setting have been complicated by the multifaceted nature of Wnt-signaling (4, 15).”
From Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib (2012) · cites this paper as [4]
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References 244 · Cited by 1,595
- Authors
- Klaus, A., & Birchmeier, W.
- Affiliations
- Max Delbrück Center (DE)
- Corresponding author
- Birchmeier, Walter
- ORCID
- Birchmeier, Walter
- Venue
- Nature Reviews Cancer
- Published
- 2008-05
- Volume
- 8
- Issue
- 5
- Pages
- 387-398
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1992127683
- Cited by
- 1,595
- References
- 244
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 47 · 2023: 53 · 2022: 85 · 2021: 110 · 2020: 87 · 2019: 92 · 2018: 94 · 2017: 126 · 2016: 107 · 2015: 112 · 2014: 125 · 2013: 134 · 2012: 115
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt signalling pathway, embryonic development, tissue regeneration, cancer, int1, wingless, Drosophila melanogaster, epistasis
- MeSH terms
- Animals, Humans, Mutation, Neoplasms, Stem Cells, Signal Transduction, Embryonic Development, History, 20th Century, History, 21st Century, Wnt Proteins, Wnt1 Protein, Mice
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