Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer

Kirn, David H., Thorne, Steve H.·2009·Nature Reviews Cancer

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  1. Targeted Inhibition of p21 Promotes the Growth of Breast Cancer Cells and Impairs the Tumor-Killing Effect of the Vaccinia Virus
    Xiaoyuan Jia, Yujia Zhao, Qiang Li, Xiaming Lu, Xiaoyan Wang, Hui Wang, Ziyi Shi, Yipeng Xu, Biao Huang, Fang Huang et al. · 2024 · Journal of Breast Cancer
  2. Targeted therapy of human glioblastoma combining the oncolytic properties of parvovirus H-1 and attenuated strains of the vaccinia virus
    A. V. Tkacheva, Galina F. Sivolobova, Antonina A. Grazhdantseva, Oleg B. Shevelev, И. А. Разумов, Evgeny L. Zavjalov, Valery B. Loktev, Galina V. Kochneva · 2019 · Molecular Genetics Microbiology and Virology (Russian)
  3. Efficacy of a new oncolytic adenovirus armed with IL-13 against oral carcinoma models
    Kailiang Zhang, Ruiping Li, Bao-Ping Zhang, Shuting Gao, Bo Li, Chun-Juan Huang, Rui Cao, Jingyang Cheng, Xiaodong Xie, Zhanhai Yu et al. · 2019 · OncoTargets and Therapy
  4. Engineering precision therapies: lessons and motivations from the clinic
    Mingqi Xie, Mirta Viviani, Martin Fussenegger · 2020 · Synthetic Biology
  5. Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer
    Christina Kober, Stephanie Weibel, Susanne Rohn, Lorenz Kirscher, Aladar A. Szalay · 2015 · Molecular Therapy — Oncolytics
  6. Categorization of cancer through genomic complexity could guide research and management strategies
    Hugo M. Horlings, Adrienne Margaret Flanagan, David D. Huntsman · 2015 · The Journal of Pathology
  7. Oncolytic Sendai virus‐induced tumor‐specific immunoresponses suppress “simulated metastasis” of squamous cell carcinoma in an immunocompetent mouse model
    Yuya Tanaka, Koji Araki, Shingo Tanaka, Yoshihiro Miyagawa, Hiroshi Suzuki, Daisuke Kamide, Masayuki Tomifuji, Kosuke Uno, Eiko Harada, Taku Yamashita et al. · 2019 · Head & Neck
  8. A Comparative Study of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins in Breast Cancer Cells
    Yanrong Zhou, Qianpeng Wang, Qi Ying, Xiaomei Zhang, Ting Ye, Kan Chen, Gongchu Li · 2023 · Marine Drugs
  9. Drug-Encoded Biomarkers for Monitoring Biological Therapies
    Desislava Tsoneva, Jochen Stritzker, Kristina Bedenk, Qian Zhang, Alexa Frentzen, Joseph Cappello, Utz Fischer, Aladar A. Szalay · 2015 · PLoS ONE
  10. Antitumor activity of recombinant oncolytic vaccinia virus with human IL2
    Liqiong Liu, Huiqun Li, Qinggang Xu, Yanyou Wu, Dongfeng Chen, Feng Yu · 2022 · Open Medicine
  11. Confidentiality -- revealing trends in bioethics.
    Lisa S. Parker, Robert M. Arnold · 1998 · PubMed
  12. Win or loss? Combination therapy does improve the oncolytic virus therapy to pancreatic cancer
    Wenhao Luo, Yawen Wang, Taiping Zhang · 2022 · Cancer Cell International
  13. Viral/Non-Viral Vectors in DNA/RNA Delivery Technology
    Hossein Hosseinkhani · 2024 · Recent Progress in Materials
  14. Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment
    Yumiko Yamada, Yu‐Chih Wang, Hao‐Ping Liu, Greg Ryan Gerongano, Ching‐Yu Tseng, Shu‐Chen Liu, Guan‐Ru Liao, Chao‐Chin Chang, Jiunn‐Wang Liao, Meilin Wang et al. · 2025 · Virology Journal
  15. Differential biodistribution of oncolytic poxvirus administered systemically in an autochthonous model of hepatocellular carcinoma
    Patrick Baril, Yann Touchefeu, Jeannette Cany, Yan Chérel, Stephen H. Thorne, Lucile Tran, Sophie Conchon, Georges Vassaux · 2011 · The Journal of Gene Medicine
  16. N-Myc expression enhances the oncolytic effects of vesicular stomatitis virus in human neuroblastoma cells
    Juan Carlos Corredor, Nicole Redding, Karen R. Blote, Stephen M. Robbins, Donna L. Senger, John Cameron Bell, Paul Beaudry · 2016 · Molecular Therapy — Oncolytics
  17. Design Strategies and Precautions for Using Vaccinia Virus in Tumor Virotherapy
    Xinjun Liu, Jian Zhao, Xiaopeng Li, Fengxue Lao, Min Fang · 2022 · Vaccines
  18. Passive and Active Targeting for Solid Tumors
    Mahesh Prabhakar More, Prashant Krishnarao Deshmukh, Pravin Onkar Patil, Sopan Nangare, Rahul Shankar Tade, Ashwini Patil, Abhijeet P. Pandey, Srinivas Mutalik, Prashant Bhagwan Patil, Zamir Gaffar Khan et al. · 2022 · Environmental chemistry for a sustainable world
  19. Apoptosis-inducing effect of myxoma virus on human neuroglioma cell lines
    Qiu-Sheng Zhang, Meng Zhang, Xianjian Huang, Xiaojia Liu, Weiping Li · 2017 · Experimental and Therapeutic Medicine
  20. Utility of Mouse Models in Vaccine Design and Development
    Catharine M. Bosio, Megan K. L. MacLeod, Philippa Marrack, Ross M. Kedl · 2012
  21. Gene Therapy and Virus-Based Cancer Vaccines
    Mohamed Labib Salem, Kamal K.E. Gadalla, Burtram Clinton Fielding, Stephen H. Thorne · 2014 · Springer eBooks
  22. Advances in DNA- and RNA-Based Oncolytic Viral Therapeutics and Immunotherapies
    Peter Anto Johnson, Alyssa Wu, John C. Johnson, Zachary Schauer, Terrence Wu, Francis Fernandes, Reinette Schabert, Austin Albert Mardon · 2022 · Applied Microbiology
  23. Targeted Therapy of Human Glioblastoma Combining the Oncolytic Properties of Parvovirus H-1 and Attenuated Strains of the Vaccinia Virus
    A. V. Tkacheva, Galina F. Sivolobova, Antonina A. Grazhdantseva, Oleg B. Shevelev, И. А. Разумов, Evgeny L. Zavjalov, Valery B. Loktev, Galina V. Kochneva · 2019 · Molecular Genetics Microbiology and Virology
  24. Review on Application of Oncolytic Virotherapy of Cancer Cells in Veterinary Medicine
    Tamirat Demissie · 2020 · Advances in life science and technology
  25. Synthetic Biology for the Development of Biodrugs and Designer Crops and the Emerging Governance Issues
    Archana Chugh, Pooja Bhatia, Aastha Jain · 2014 · Springer eBooks
  26. Therapeutic strategies for controlling the metastasis and recurrence of cancers: contribution of drug delivery technologies
    Yasufumi Kaneda · 2012 · Advanced Drug Delivery Reviews
  27. Large Virus for an Even Bigger Task: Can the Mimivirus Close the Gene-Therapy Vector Void?
    Aartjan J.W. te Velthuis · 2009 · Future Virology
  28. Targeted Oncolytic Adenovirus for Human Cancer Therapy: Gene-Based Therapies for Cancer
    Toshiyoshi Fujiwara · 2010 · Springer eBooks
  29. Enhancing biological therapy through conditional regulation of protein stability
    Stephen H. Thorne · 2010 · Expert Reviews in Molecular Medicine
  30. Antitumoral activity of oncolytic vaccinia virus expressing the interferon-induced ds-RNA dependent protein kinase PKR
    María Ángeles Villegas García, Magdalena Krupa, Mariano Estéban · 2010 · Anales de la Real Academia Nacional de Farmacia
  31. Reporter Transgenes for Monitoring the Antitumor Efficacy of Recombinant Oncolytic Viruses
    Anastasiya V. Semenova, Galina F. Sivolobova, Antonina A. Grazhdantseva, Alexander P. Agafonov, Galina V. Kochneva · 2022 · Acta Naturae
  32. Global trends of Vaccinia oncolytic virus therapy over the past two decades: Bibliometric and visual analysis
    Bo Liu, Tianming Liu, Fan Fengliang, Liang Wenping, Han Jinzuo, Xue Dong-bo, Biao Ma, Haijun Sun · 2023 · Frontiers in Immunology
  33. Application of Oncolytic Poxviruses: An Emerging Paradigm in Cancer Therapy
    Prasenjit Chakraborty, Ranjit Kumar, Sanjay Karn, Dharmiben D. Raviya, Priya Mondal · 2024 · Advances in experimental medicine and biology
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    Idris Zubairu Sadiq, Fatima Sadiq Abubakar, Hassan Aliyu Hassan · 2021 · Preprints.org
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    Akmal Zubair, Lazaros Lazarou, Abdullah M. Alkahtani, Muhammad Yaqoob Shahani, Naila Afghan · 2026 · Discover Oncology
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  39. Cancer terminator viruses: Unique conditionally replication competent oncolytic viruses producing therapeutic anti-cancer immunomodulating agents
    Pritam Roy, Mir Shahid Maqbool, Narsimha Mamidi, Padmanabhan Mannangatti, Theresa Gammel, David D. Limbrick, Devanand Sarkar, Swadesh K. Das, Paul B. Fisher · 2026 · Advances in cancer research
  40. Imaging of Oncolytic Virus Gene Expression
    Juan J. Rojas, Stephen H. Thorne · 2013 · Elsevier eBooks
  41. Vaccinia Viral Vectors for Vaccines and Oncolytic Virotherapy
    Z. Sheng Guo, Judith Andrea McCart, David L. Bartlett · 2015 · CRC Press eBooks
  42. Virus Vectors
    Wang‐Shick Ryu · 2016 · Elsevier eBooks
  43. Evolution of Reovirus in Cancer Therapy
    Bindhu Jayaprakash, Sivapriya Veeraiyan, Silambarasan Gunaseelan, Yasodha Purushothaman · 2017 · IOSR Journal of Pharmacy and Biological Sciences
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    Iliana Georgana, Simon R. Scutts, Chen Gao, Yongxu Lu, Alice A. Torres, Hongwei Ren, Edward Emmott, Jinghao Men, Keefe Oei, Geoffrey L. Smith · 2024 · Journal of Virology
  45. Enhanced Antitumor Efficacy of Oncolytic Vaccinia Virus Therapy Through Keratin-Mediated Delivery in Triple-Negative Breast Cancer
    Hyosung Kim, Yun Hee Youn, Han‐Jun Kim, Young-Hyun Koo, Junho Lee, Il Keun Kwon, Sun Hee · 2024 · International Journal of Molecular Sciences
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  48. Exploring the Oncolytic Potentail of a Double Knock-Out Tanapoxvirus Containing FLiC Transgene
    Esaw Kurban · 2015
  49. Oncolytic Viruses and Histone Deacetylase Inhibitors
    Vaishali Manikrao Patil, Satya P. Gupta · 2014 · CRC Press eBooks
  50. Gene Therapy and Oncolytic Viruses
    Tanja Tamgüney, Wolfgang Michael Korn, Frank P. McCormick · 2015 · Elsevier eBooks
  51. General Principles of Immunotherapy for Glioblastoma
    Andrew I. Yang, Marcela Valderrama Maus, Donald M. O’Rourke · 2016 · Elsevier eBooks
  52. Future directions for gene therapy
    Yasufumi Kaneda · 2013
  53. Vaccinia virus modulates the host cell cycle to promote infection
    Caroline K. Martin · 2019 · UCL Discovery (University College London)
  54. DEVELOPING GENETICALLY ENGINEERED ONCOLYTIC VIRUSES FOR CANCER GENE THERAPY
    Suvi Parviainen · 2015 · Työväentutkimus Vuosikirja
  55. Efficacy and safety of oncolytic vaccinia virus and Semliki Forest virus in the treatment of canine and feline malignant tumours
    Karoliina Autio · 2015 · Työväentutkimus Vuosikirja
  56. New Strategies for the Treatment of Adrenocortical Carcinoma
    Lawrence Steven Kirschner · 2009 · Springer eBooks
  57. Exploiting Differential Endogenous MicroRNA Expression to Enhance Oncolytic Vesicular Stomatitis Virus Tumour Tropism
    Robert E. Edge · 2010 · uO Research (University of Ottawa)
  58. Therapeutic strategies for controlling metastasis and recurrence of cancers
    Yasufumi Kaneda · 2010 · Drug Delivery System
  59. Ein Pockenvirus gegen Tumorzellen
    Alissa Linder, Giorgio Marino, Julia Prechtel, Dorothee Rest, Floriana Sabatino, Ilse Zündorf, Theo Dingermann · 2012 · Pharmazie in unserer Zeit
  60. Characterization of the E3L Amino-Terminus in Poxvirus Replication and Tumor Regression
    William D. Arndt · 2010
  61. The Combination of Carboxylesterase-Expressing Oncolytic Vaccinia Virus and Irinotecan
    Michelle Caitlin Becker · 2013 · uO Research (University of Ottawa)
  62. Targeted Toxins in Cancer Immunotherapy
    Devalingam Mahalingam, Michael J. Brumlik, Reinhard Waehler, David T. Curiel, Tyler Jay Curiel · 2012 · Springer eBooks
  63. Enhancing the Delivery of Oncolytic Vaccinia Virus to the Tumors of Hosts with Pre-Existing Immunity
    Laura Evgin · 2015 · uO Research (University of Ottawa)
  64. Modification of regulatory and catalytic properties of phosphorylase-b by irradiation and heat.
    Sándor Damjanovich, G. Csécsei, János Sümegi · 1971 · PubMed
  65. Evaluation of the anti-tumour potency and biodistribution of vaccinia virus mutants in solid tumour models
    Jonathan Hughes · 2013
  66. Enhancing the Oncolytic Efficacy of Vaccinia Virus by Mutagenic Augmentation of EEV Production
    Aimée N. Laporte · 2012 · uO Research (University of Ottawa)
  67. the immune system against cancer using oncolytic vaccinia and other viruses
    Fiona Errington‐Mais, Alan A. Melcher · 2014
  68. Vaccines and Their Role in CD8 T Cell-Mediated Antitumor Immunity
    Heather L. Kinkead, Elizabeth M. Jaffee, Eric R. Lutz, Todd D. Armstrong · 2016 · Elsevier eBooks
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    Jessica Tong · 2016 · Scholarship@Western (Western University)
  70. The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent
    Jahangir Ahmed, Ming Yuan, Ghassan Alusi, Nicholas Robert Lemoine, Yaohe Wang · 2013 · Elsevier eBooks
  71. Gene Therapy: Technologies and Applications
    Ryuichi Morishita, Hironori Nakagami · 2013
  72. In vitro Anti-tumor Effect of an Engineered Vaccinia Virus in Multiple Cancer Cells and ABCG2 Expressing Drug Resistant Cancer Cells
    Ji‐Hye Park, Jisoo Yun, Jeong Heo, Tae Ho Hwang, Sang‐Mo Kwon · 2016 · Journal of Life Science
  73. Synthetic Biology Will Reinvigorate New Generation Drugs, Vaccines and Biofuels Research and Development
    Sami Ullah Jan, Burhan Ullah, Aimal Khan, Muhammad Asif Shahzad, Atif Shafique, Muhammad Ali Abbas · 2014
  74. Assessment and development of adenovirus type 11 for cancer therapy
    Han Hsi Wong · 2010 · OpenGrey (Institut de l'Information Scientifique et Technique)
  75. Advance on research of oncolytic vaccinia virus inhibits tumor cells
    Xiaoyuan Jia, YanZi GUO · 2017 · Scientia Sinica Vitae
  76. Evolution of Reovirus in Cancer Therapy
    Bindhu Jayaprakash, Sivapriya Veeraiyan, Silambarasan Gunaseelan, Yasodha Purushothaman · 2017 · IOSR Journal of Pharmacy and Biological Sciences
  77. Optimising Oncolytic Virotherapy and Immunotherapy for the treatment of Disseminated Colorectal Cancer
    Adam Peckham-Cooper · 2017 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
  78. REOVIRUS-DRIVEN MYELOID CELLS IN ONCOLYTIC VIRUS THERAPY AND INFECTION
    Derek R. Clements · 2018 · DalSpace (Dalhousie University)
  79. Development of a Mathematical Model to Understand, Design & Improve Oncolytic Virus Therapies
    Cory Batenchuk · 2014 · uO Research (University of Ottawa)
  80. Engineering escherichia coli for nanoparticle synthesis and targeting of colon cancer
    Rupali Reddy Pasula · 2018 · DR-NTU (Nanyang Technological University)
  81. Oncolytic Herpes Simplex Virus ICP47 Deletion Reverses Tumor Immune Evasion
    Jun-Ting Cheng, Yingying Wang, Ying Zhang, Wen-Qi Cai, Yang Zhou, Zi-Wen Han, Xiaoqin Liu, Xianwang Wang, Xiaochun Pen, Ying Xiang et al. · 2018 · Yangtze Medicine
  82. Screening of p53-MDM2 interaction inhibitors through genome editing, high-content screening, and surface plasmon resonance
    Hakan Taşkıran · 2018 · Sabanci University
  83. Immunotherapy of cancer
    Sanyog Jain, Kaisar Raza, Ashish Kumar Agrawal, Ankur Vaidya · 2020 · Elsevier eBooks
  84. New intratumoral immunotherapeutic approaches to inhibit the tumor growth and metastasis in breast cancer
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  85. TREATMENT POSSIBILITIES FOR ACQUIRED AND HEREDITARY DISEASES BY GENE THERAPY: A REVIEW
    P. V. KAMALA KUMARI, V. HARIKA G. EKSHITHA · 2021 · International Journal of Applied Pharmaceutics
  86. The Oncolytic Potential of Tanapoxvirus to Treat Retinoblastoma
    John D. Christie · 2016
  87. Oncolytic Viruses and Histone Deacetylase Inhibitors
    Vaishali Manikrao Patil, Satya Gupta · 2014 · CRC Press eBooks
  88. Faculty Opinions recommendation of Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.
    Philip Joseph Rosenthal · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  89. ESGCT, DGGT, GSZ, and ISCT 2009 Invited Presentations
    2009 · Human Gene Therapy
  90. Progress of Cancer Nano Medicine, Clinical Hurdles, and Opportunities
    Priti Tagde, Anshul Sharma, Kamya Goyal, Shammy Jindal · 2022 · Springer eBooks
  91. Data from Host Lymphodepletion Enhances the Therapeutic Activity of an Oncolytic Vaccinia Virus Expressing 4-1BB Ligand
    Hong Sung Kim, Seunghee Kim‐Schulze, Daewon Kim, Howard L. Kaufman · 2023
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  96. Cloning a gene involved in antigen presentation to be expressed by an oncolytic virus
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