Targeting protein prenylation for cancer therapy

Berndt, Norbert, Hamilton, Andrew D., Sebti, Saïd M.·2011·Nature Reviews Cancer

Cited by (622)

Items 301–400 of 622

  1. A Novel c-MET-Targeting Antibody-Drug Conjugate for Pancreatic Cancer
    Yangbing Jin, Zehui Zhang, Siyi Zou, Fanlu Li, Hao Chen, Chenghong Peng, Xiaxing Deng, Chenlei Wen, Baiyong Shen, Qian Zhan · 2021 · Frontiers in Oncology
  2. Regioselective Covalent Immobilization of Catalytically Active Glutathione S-Transferase on Glass Slides
    Rajesh Viswanathan, Guillermo R. Labadié, C. Dale Poulter · 2013 · Bioconjugate Chemistry
  3. Therapeutic Approaches to RAS Mutation
    Aaron James Scott, Christopher Hanyoung Lieu, Wells A. Messersmith · 2016 · The Cancer Journal
  4. Targeting Hepatitis D
    Mario Rizzetto · 2018 · Seminars in Liver Disease
  5. Methoxy-Substituted Nitrodibenzofuran-Based Protecting Group with an Improved Two-Photon Action Cross-Section for Thiol Protection in Solid Phase Peptide Synthesis
    Taysir K. Bader, Feng Ying Xu, Michael H. Hodny, David A. Blank, Mark Dewey Distefano · 2019 · The Journal of Organic Chemistry
  6. Addressing the Right Targets in Oncology: Challenges and Alternative Approaches
    Julie K. Stock, Neil P. Jones, Tim R. Hammonds, Jon Roffey, Christian Dillon · 2015 · SLAS DISCOVERY
  7. Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics
    Mengke Xu, Bo Xu · 2025 · Molecular Cancer
  8. Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer
    J. Nathaniel Diehl, Priya S. Hibshman, Irem Ozkan‐Dagliyan, Craig M. Goodwin, Sarah V. Howard, Adrienne D. Cox, Channing J. Der · 2022 · Advances in cancer research
  9. Use of Synthetic Isoprenoids to Target Protein Prenylation and Rho GTPases in Breast Cancer Invasion
    Min Chen, Teresa Knifley, Thangaiah Subramanian, H. Peter Spielmann, Kathleen L. O’Connor · 2014 · PLoS ONE
  10. Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation
    Yen-Chih Wang, Mark Dewey Distefano · 2012 · Chemical Communications
  11. Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies
    Muhammad Mansha, Udhaya Kumari Udayappan, Zoe Cournia, Nisar Ullah · 2016 · European Journal of Medicinal Chemistry
  12. Transcriptomics Reveals the Mevalonate and Cholesterol Pathways Blocking as Part of the Bacterial Cyclodipeptides Cytotoxic Effects in HeLa Cells of Human Cervix Adenocarcinoma
    Pedro Eduardo Lázaro-Mixteco, José Manuel González-Coronel, Laura Hernández-Padilla, Lorena Martínez Alcantar, Enrique Martínez-Carranza, Jesús Salvador López‐Bucio, Ángel Arturo Guevara-García, Jesús Campos‐García · 2022 · Frontiers in Oncology
  13. GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS
    Olivia J. Koehn, Ellen Lorimer, Bethany Unger, Ra’Mal M. Harris, Akansha S. Das, Kiall F. Suazo, Shelby A. Auger, Mark Dewey Distefano, Jeremy W. Prokop, Carol L. Williams · 2023 · Journal of Biological Chemistry
  14. Advances in the development of Rho GTPase inhibitors
    Yijing Zhang, Guanyi Li, Yaxue Zhao · 2023 · Bioorganic & Medicinal Chemistry
  15. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
    Keith Graham, Philip Lienau, Benjamin Bader, Stefan Prechtl, Jan Naujoks, Ralf Lesche, Joerg Weiske, Julia Kuehnlenz, Krzysztof Brzezinka, Lisette Potze et al. · 2024 · Cell chemical biology
  16. Molecular Genetics of Pancreatic Neoplasms
    Waki Hosoda, Laura DeLong Wood · 2016 · Surgical pathology clinics
  17. Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density
    David A. Hottman, Shaowu Cheng, Andrea Gram, Kyle J. LeBlanc, Li‐Lian Yuan, Ling Li · 2018 · Neuroscience
  18. Statins Perturb Gβγ Signaling and Cell Behavior in a Gγ Subtype Dependent Manner
    Mithila Tennakoon, Dinesh Kankanamge, Kanishka Senarath, Zehra Fasih, Ajith Karunarathne · 2019 · Molecular Pharmacology
  19. Splice-switching as cancer therapy
    Amina Jbara, Zahava Siegfried, Rotem Karni · 2021 · Current Opinion in Pharmacology
  20. Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls
    Joris W. De Schutter, Joseph Shaw, Yih‐Shyan Lin, Youla S. Tsantrizos · 2012 · Bioorganic & Medicinal Chemistry
  21. Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6
    Bilal Muhammad Qureshi, Andrea Schmidt, Elmar Behrmann, Jörg Bürger, Thorsten Mielke, Christian M. T. Spahn, Martin Heck, Patrick Scheerer · 2018 · Nature Communications
  22. Targeting Mutant KRAS for Anticancer Therapy
    Fengqian Chen, Martin Prince Alphonse, Yan Liu, Qi Liu · 2019 · Current Topics in Medicinal Chemistry
  23. Past and Future Strategies to Inhibit Membrane Localization of the KRAS Oncogene
    Malak Haidar, Patrick Jacquemin · 2021 · International Journal of Molecular Sciences
  24. Pancreatic cancer, treatment options, and GI-4000
    Marion L. Hartley, Najeebah A. Bade, Petra Prins, Leonel Ampie, John Lindsay Marshall · 2015 · Human Vaccines & Immunotherapeutics
  25. Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets
    Qusai Al Abdallah, Jarrod R. Fortwendel · 2015 · Frontiers in Microbiology
  26. Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications
    Yen-Chih Wang, Mark Dewey Distefano · 2015 · Bioorganic Chemistry
  27. Nano-assemblies overcome cancer multidrug resistance for effectively synergistic chemo-immuno-oncotherapy
    Yingnan Liu, Guofang Zhang, Qi Li, Jiaxin Chen, Wenhe Luo, xuejin Li, Xiaoman Suo, Li Su, Yaqing Xu, Tinghao Liu et al. · 2024 · Chemical Engineering Journal
  28. Targeting the Ras pathway in pediatric hematologic malignancies
    Yana Pikman, Elliot Stieglitz · 2020 · Current Opinion in Pediatrics
  29. Protein farnesylation negatively regulates brassinosteroid signaling via reducing BES1 stability in Arabidopsis thaliana
    Zengxiu Feng, Hongyong Shi, Minghui Lv, Yuang Ma, Jia Li · 2021 · Journal of Integrative Plant Biology
  30. Rerouting the drug response: Overcoming metabolic adaptation in KRAS-mutant cancers
    Debbie Moss, Christopher K. McCann, Emma M. Kerr · 2022 · Science Signaling
  31. Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS)
    Yuting Feng, Jaeok Park, Shiguang Li, Rebecca Boutin, Peter Viereck, Matthew Aaron Schilling, Albert Marinus Berghuis, Youla S. Tsantrizos · 2019 · Journal of Medicinal Chemistry
  32. Progeria and Aging—Omics Based Comparative Analysis
    Aylin Caliskan, Samantha A. W. Crouch, Sara Giddins, Thomas Dandekar, Seema Dangwal · 2022 · Biomedicines
  33. Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007 – present)
    Elena Sacco, Michela Spinelli, Marco Vanoni · 2012 · Expert Opinion on Therapeutic Patents
  34. NMR in integrated biophysical drug discovery for RAS: past, present, and future
    Christopher B. Marshall, Fenneke KleinJan, Teklab Gebregiworgis, Ki‐Young Lee, Zhenhao Fang, Ben J. Eves, Ningdi F. Liu, Geneviève M. C. Gasmi-Seabrook, Masahiro Enomoto, Mitsuhiko Ikura · 2020 · Journal of Biomolecular NMR
  35. Novel role of Cdc42 and RalA GTPases in TNF-α mediated secretion of CCL2
    Kelly Ann Langert, Cynthia Lynn Pervan, Evan B. Stubbs · 2014 · Small GTPases
  36. Targeting Ras with Macromolecules
    Dehua Pei, Kuangyu Chen, Hui Liao · 2017 · Cold Spring Harbor Perspectives in Medicine
  37. Geranylgeranyltransferase I regulates HIF-1α promoting glioblastoma cell migration and invasion
    Xiuping Zhou, Zhi Liu, Qiong Shi, Jiantong Jiao, Wenbin Bian, Xu Song, Jianbing Mo, Ben Sang, Yinfu Xu, Jinming Qian et al. · 2013 · Journal of Neuro-Oncology
  38. Breast Cancer Cell Targeting by Prenylation Inhibitors Elucidated in Living Animals with a Bioluminescence Reporter
    Sharon L. Chinault, Julie L. Prior, Kevin M. Kaltenbronn, Anya Penly, Katherine N. Weilbaecher, David R Piwnica-Worms, Kendall Blumer · 2012 · Clinical Cancer Research
  39. A mini-review on the enzyme-mediated manipulation of proteins/peptides
    Shaomin Lin, Chunmao He · 2018 · Chinese Chemical Letters
  40. Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans
    Jiaojiao Ji, Yuan Gang Jiang, Xiaoyu Guo, Ruifang Ji, Qinghua Quan, Mei Ding, Xia Li, Yonggang Liu · 2019 · Cancer Cell International
  41. Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens
    Sang Hu Kim, Chunliang Liu, Yasheen Zhou, Yongkang Zhang, Cari McGregor, Luke Steere, Brittany H. Frederick, C. Tony Liu, Luke J. Whitesell, Leah E. Cowen · 2020 · ACS Chemical Biology
  42. Future directions in drug development in pancreatic cancer
    Aurélien Lambert, Thierry Conroy, Michel Pierre Ducreux · 2021 · Seminars in Oncology
  43. Mass Spectrometry Cleavable Strategy for Identification and Differentiation of Prenylated Peptides
    Ruchika P. Bhawal, Sandhya C. Sadananda, Alejandro Bugarin, Brian Laposa, Saiful M. Chowdhury · 2015 · Analytical Chemistry
  44. Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway
    Yu‐Sheng Yeh, Tsuyoshi Goto, Nobuyuki Takahashi, Kahori Egawa, Haruya Takahashi, Huei‐Fen Jheng, Young‐Il Kim, Teruo Kawada · 2016 · Biochemical and Biophysical Research Communications
  45. Toward the Goal of Personalized Therapy in Pancreatic Cancer by Targeting the Molecular Phenotype
    Nelson S. Yee · 2012 · Advances in experimental medicine and biology
  46. Lipid Modification of Proteins
    Marilyn D. Resh · 2015 · Elsevier eBooks
  47. Direkte Modulation von Rab‐GTPase‐Effektor‐Wechselwirkungen
    Jochen Spiegel, Philipp M. Cromm, Aymelt Itzen, Roger Sidney Goody, Tom N. Grossmann, Herbert Waldmann · 2014 · Angewandte Chemie
  48. Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin
    Dan-Xia Deng, Chengyu Li, Zhen-Yuan Zheng, Bing Wen, Lian‐Di Liao, Xiaojun Zhang, En‐Min Li, Li‐Yan Xu · 2023 · Molecular & Cellular Proteomics
  49. The Biosynthesis and Applications of Protein Lipidation
    Wenlong Ding, Jiayu Gu, Wenyuan Xu, Jing Wu, Yi‐Wen Huang, Shuai Zhang, Shixian Lin · 2024 · Chemical Reviews
  50. Protein prenylation in mechanotransduction: implications for disease and therapy
    Heng Chen, Jian Yang, Qingzhen Yang, Yuanbo Jia, Xiaogang Guo · 2025 · Trends in Pharmacological Sciences
  51. Intracellular oxygen determined by respiration regulates localization of Ras and prenylated proteins
    Anne Claire Kim, R Davis, Masahiro Higuchi · 2015 · Cell Death and Disease
  52. Mutant-Specific Targeting of Ras G12C Activity by Covalently Reacting Small Molecules
    Roger Sidney Goody, Matthias Philipp Müller, Daniel Rauh · 2019 · Cell chemical biology
  53. Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association
    Mo Zhou, Leena Kuruvilla, Xiarong Shi, Stephen Viviano, Ian M. Ahearn, Caroline R. Amendola, Wenjuan Su, Sana Badri, James P. Mahaffey, Nicole Fehrenbacher et al. · 2020 · Proceedings of the National Academy of Sciences
  54. Cis,cis,trans -[Pt IV Cl 2 (NH 3 ) 2 (perillato) 2 ], a dual-action prodrug with excellent cytotoxic and antimetastatic activity
    Mauro Ravera, Elisabetta Gabano, Ilaria Zanellato, Beatrice Rangone, Elena Perin, Beatrice Ferrari, Maria Grazia Bottone, Domenico Osella · 2021 · Dalton Transactions
  55. Drug targeting opportunities en route to Ras nanoclusters
    Karolina Pavic, Rohan Chippalkatti, Daniel Abankwa · 2022 · Advances in cancer research
  56. Targeted Reengineering of Protein Geranylgeranyltransferase Type I Selectivity Functionally Implicates Active-Site Residues in Protein-Substrate Recognition
    Soumyashree A. Gangopadhyay, Erica L. Losito, James L. Hougland · 2013 · Biochemistry
  57. a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity
    Veronica Diaz-Rodriguez, Erh‐Ting Hsu, Elena E. Ganusova, Elena R. Werst, Jeffrey M. Becker, Christine A. Hrycyna, Mark Dewey Distefano · 2017 · Bioconjugate Chemistry
  58. Biomarkers for personalized medicine in GI cancers
    Shuang Yin Zhang, Shuang Qin Zhang, Ganji Purnachandra Nagaraju, Bassel F. El‐Rayes · 2015 · Molecular Aspects of Medicine
  59. Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration
    Guoyuan Peng, Yuan Ren, Xiaodong Sun, Jun Zhou, Dengwen Li · 2012 · Biochemical Pharmacology
  60. Combined p21-activated kinase and farnesyltransferase inhibitor treatment exhibits enhanced anti-proliferative activity on melanoma, colon and lung cancer cell lines
    Giampiero Porcu, Ainslie B. Parsons, Daniele Di Giandomenico, Giuseppe Lucisano, Maria Giovanna Mosca, Charles M. Boone, Antonella Ragnini‐Wilson · 2013 · Molecular Cancer
  61. A proteomic glimpse into the effect of antimalarial drugs onPlasmodium falciparumproteome towards highlighting possible therapeutic targets
    Majid Dousti, Raúl Manzano-Román, Sajad Rashidi, Gholamreza Barzegar, Niloofar Bavarsad Ahmadpour, Alireza Mohammadi, Gholamreza Hatam · 2020 · Pathogens and Disease
  62. Affinity and chemical enrichment strategies for mapping low‐abundance protein modifications and protein‐interaction networks
    Adway O. Zacharias, Zixiang Fang, Aurchie Rahman, Akash Talukder, Sharel Cornelius, Saiful M. Chowdhury · 2020 · Journal of Separation Science
  63. Targeting the Isoprenoid Biosynthetic Pathway in Multiple Myeloma
    Staci L. Haney, Sarah A. Holstein · 2022 · International Journal of Molecular Sciences
  64. Geranylgeranyltransferase I Promotes Human Glioma Cell Growth through Rac1 Membrane Association and Activation
    Xiuping Zhou, Jinming Qian, Lei Hua, Qiong Shi, Zhi Liu, Yinfu Xu, Ben Sang, Jianbing Mo, Rutong Yu · 2012 · Journal of Molecular Neuroscience
  65. Genome-wide Screen for Modulation of Hepatic Apolipoprotein A-I (ApoA-I) Secretion
    Rebecca R. Miles, William Perry, Joseph V. Haas, Marian K. Mosior, Mathias N'Cho, JianW.J. Wang, Peng Yu, John N. Calley, Yong Gang Yue, Quincy L. Carter et al. · 2013 · Journal of Biological Chemistry
  66. In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida
    Jianjun Qiao, Peiping Gao, Xiaoling Jiang, Hong Fang · 2013 · Annals of Clinical Microbiology and Antimicrobials
  67. Specific and Efficient Regression of Cancers Harboring KRAS Mutation by Targeted RNA Replacement
    Sung Jin Kim, Ju Hyun Kim, Bitna Yang, Jin‐Sook Jeong, Seong‐Wook Lee · 2017 · Molecular Therapy
  68. SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent
    Benjamin C. Jennings, Alexis J. Lawton, Zeinab Rizk, Carol A. Fierke · 2018 · Biochemistry
  69. Enantioselectivity and Reactivity Enhancement by 1,1,3,3-Tetramethylguanidine in Bisguanidinium-Catalyzed Asymmetric Alkylation for Construction of Indole Alkaloid Marine Natural Products
    Xiong Zuo, Zhenghao Wan, Zhihuan Liao, Chao Wang, Choon‐Hong Tan, Shuaidong Huo, Lili Zong · 2023 · ACS Catalysis
  70. Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function
    Sameer Ahmed Bhat, Zahra Vasi, Liping Jiang, Shruthi Selvaraj, Rachel Ferguson, Sanaz Salarvand, Anish Gudur, Ritika Adhikari, Veronica Castillo, Hagar Ismail et al. · 2024 · Cell Reports
  71. Molecular dynamics analysis of a series of 22 potential farnesyltransferase substrates containing a CaaX-motif
    Sérgio Filipe Sousa, João T. S. Coimbra, Diogo Paramos-de-Carvalho, Rita A. Pinto, Rodrigo S. Guimarães, Vítor Teixeira, Pedro Alexandrino Fernandes, Maria João Ramos · 2012 · Journal of Molecular Modeling
  72. Efficacy of fluvastatin and aspirin for prevention of hormonally insensitive breast cancer
    Anjana Bhardwaj, Matthew D. Embury, Raniv Dawey Rojo, Constance T. Albarracin, Isabelle Bedrosian · 2021 · Breast Cancer Research and Treatment
  73. Lonafarnib Inhibits Farnesyltransferase via Suppressing ERK Signaling Pathway to Prevent Osteoclastogenesis in Titanium Particle-Induced Osteolysis
    Linke Huang, Weiwei Chen, Linhua Wei, Yuangang Su, Jiamin Liang, Haoyu Lian, Hui Wang, Feng Long, Fan Yang, Shiyao Gao et al. · 2022 · Frontiers in Pharmacology
  74. Inhibition of NRAS Signaling in Melanoma through Direct Depalmitoylation Using Amphiphilic Nucleophiles
    Hetika Vora Patel, Mai Johnson, Roberto J. Brea, Andrew K. Rudd, Neal K. Devaraj · 2020 · ACS Chemical Biology
  75. Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells
    Jie Lu, Kohei Yoshimura, Kōichi Goto, Craig R. Lee, Ken Hamura, Ohyun Kwon, Fuyuhiko Tamanoi · 2015 · PLoS ONE
  76. Basics of Radiation Therapy
    Elaine M. Zeman, Eric C. Schreiber, Joel E. Tepper · 2014 · Elsevier eBooks
  77. Polyisoprenylated Cysteinyl Amide Inhibitors Deplete K-Ras and Induce Caspase-dependent Apoptosis in Lung Cancer Cells
    Augustine T. Nkembo, Felix Amissah, Elizabeth Ntantie, Rosemary A. Poku, Olufisayo O. Salako, Offiong Francis Ikpatt, Nazarius Saah Lamango · 2019 · Current Cancer Drug Targets
  78. Early-stage structure-based drug discovery for small GTPases by NMR spectroscopy
    Guowei Yin, Guohua Lv, Jerry Zhang, Hongmei Jiang, Tianqi Lai, Yushan Yang, Yong Ren, Jing Wang, Chenju Yi, Hao Chen et al. · 2022 · Pharmacology & Therapeutics
  79. Unraveling and targeting RAS-driven metabolic signaling for therapeutic gain
    Jonathan M. DeLiberty, Ryan N. Robb, Claire E. Gates, Kirsten L. Bryant · 2022 · Advances in cancer research
  80. Mevalonate pathway and male reproductive aging
    Jia‐Le Zhang, Meng Lv, Chao‐Fan Yang, Ying‐Xi Zhu, Chaojun Li · 2023 · Molecular Reproduction and Development
  81. Synthesis, Bioproduction and Bioactivity of Perillic Acid—A Review
    Thaís de Souza Rolim, André Luiz Franco Sampaio, José Luiz Mazzei, Davyson de Lima Moreira, Antônio Carlos Siani · 2025 · Molecules
  82. Statins markedly potentiate aminopeptidase inhibitor activity against (drug-resistant) human acute myeloid leukemia cells
    Gerrit Jansen, Marjon Al, Yehuda G. Assaraf, Sarah Kammerer, Johan van Meerloo, Gert Jan Ossenkoppele, Jacqueline J Cloos, Godefridus J. Peters · 2023 · Cancer Drug Resistance
  83. New insights into RAS in head and neck cancer
    Sankar Jagadeeshan, Ofra Novoplansky, Oded M. Cohen, Ina Kurth, Jochen Heß, Ari Joseph Rosenberg, Jennifer Rubin Grandis, Moshe Elkabets · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  84. Synthesis, Enzymatic Peptide Incorporation, and Applications of Diazirine-Containing Isoprenoid Diphosphate Analogues
    Katarzyna Justyna, Riki Das, Ellen Lorimer, Jiayue Hu, Jodi S. Pedersen, Andrea M. Sprague-Getsy, Garrett L. Schey, Michelle A. Sieburg, Olivia J. Koehn, Yen‐Chih Wang et al. · 2023 · Organic Letters
  85. Crystallization and preliminary neutron diffraction experiment of human farnesyl pyrophosphate synthase complexed with risedronate
    Takeshi Yokoyama, Andreas Ostermann, Mineyuki Mizuguchi, Nobuo Niimura, Tobias E. Schrader, Ichiro Tanaka · 2014 · Acta Crystallographica Section F Structural Biology Communications
  86. Atorvastatin disrupts primary human brain microvascular endothelial cell functions via prenylation‐dependent mitochondrial inhibition and oxidative stress
    Qian Tan, Danfang Yu, Song Lin · 2020 · Fundamental and Clinical Pharmacology
  87. Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
    Jaeok Park, Dmitry Rodionov, Joris W. De Schutter, Yih‐Shyan Lin, Youla S. Tsantrizos, Albert Marinus Berghuis · 2017 · PLoS ONE
  88. The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells
    Jialiang Wang, Huan Jun Wei, Yanlin Huang, Dongmei Chen, Guofen Zeng, Yifan Lian, Yuehua Huang · 2019 · Aging
  89. Exploring the biochemistry of the prenylome and its role in disease through proteomics: progress and potential
    Maura Brioschi, Alma E. Martínez, Cristina Banfi · 2017 · Expert Review of Proteomics
  90. α-Amino bisphosphonate triazoles serve as GGDPS inhibitors
    Nathaniel R. Gehrke, Dan Feng, Md. Ayub Ali, Mona A. Maalouf, Sarah A. Holstein, David F. Wiemer · 2024 · Bioorganic & Medicinal Chemistry Letters
  91. FGTI-2734 Inhibits ERK Reactivation to Overcome Sotorasib Resistance in KRAS G12C Lung Cancer
    Aslamuzzaman Kazi, Hitesh Vasiyani, Deblina Ghosh, Dipankar Bandyopadhyay, Rachit D. Shah, Vignesh Vudatha, Jose Trevino, Saı̈d M. Sebti · 2024 · Journal of Thoracic Oncology
  92. An Alkyne-Containing Isoprenoid Analogue Based on a Farnesyl Diphosphate Scaffold Is a Biologically Functional Universal Probe for Proteomic Analysis
    Shelby A. Auger, Jodi S. Pedersen, Sanjay Maity, Andrea M. Sprague-Getsy, Ellen Lorimer, Olivia J. Koehn, Steven A. Krauklis, Brenna Berns, Katherine M. Murphy, Jamal Hussain et al. · 2024 · Biochemistry
  93. Synthetic inhibition of SREBP2 and the mevalonate pathway blocks rhabdomyosarcoma tumor growth in vitro and in vivo and promotes chemosensitization
    Silvia Codenotti, Michela Asperti, Maura Poli, Luisa Lorenzi, Alberto Pietrantoni, Matteo Cassandri, Francesco Marampon, Alessandro Fanzani · 2024 · Molecular Metabolism
  94. Melanoma: Pathogenesis and Targeted Therapy
    Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Y. Jiang · 2026 · MedComm
  95. A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7
    Hong Lin, Peter C. Simons, Anna Waller, Juan Strouse, Zurab Surviladze, Oleg Ursu, Cristian Bologa, Kristine Gouveia, Jacob Ongudi Agola, Soumik BasuRay et al. · 2013 · DigitalCommons-Cedarville (Cedarville University)
  96. Direkte Modulation von Aktivität und Funktion kleiner GTPasen
    Philipp M. Cromm, Jochen Spiegel, Tom N. Grossmann, Herbert Waldmann · 2015 · Angewandte Chemie
  97. Translating Discovery in Zebrafish Pancreatic Development to Human Pancreatic Cancer: Biomarkers, Targets, Pathogenesis, and Therapeutics
    Nelson S. Yee, Abid A. Kazi, Rosemary K. Yee · 2013 · Zebrafish
  98. Multiple mechanisms involved in a low concentration of FL118 enhancement of AMR-MeOAc to induce pancreatic cancer cell apoptosis and growth inhibition.
    Thangaiyan Rabi, Fengzhi Li · 2018 · Europe PMC (PubMed Central)
  99. KRAS G12C inhibition and innate immune targeting
    Tetsuo Tani, Shunsuke Kitajima, Ella B. Conway, Erik H. Knelson, David Allen Barbie · 2021 · Expert Opinion on Therapeutic Targets
  100. Tipifarnib enhances anti-EGFR activity of cetuximab in non-HRas mutated head and neck squamous cell carcinoma cancer (HNSCC)
    Lihua Shu, Dongsheng Wang, Sreenivas Nannapaneni, Youzhi Sun, Christopher C Griffith, Xu Wang, Zhengjia Chen, Mihir R. Patel, Mark W. El‐Deiry, Dong Moon Shin et al. · 2021 · Oral Oncology