Targeting protein prenylation for cancer therapy
Berndt, Norbert, Hamilton, Andrew D., Sebti, Saïd M.·2011·Nature Reviews Cancer
DOI 10.1038/nrc3151
Cites (221)
Items 201–222 of 222
- Inhibitors of Farnesyl Protein Transferase and MEK1,2 Induce Apoptosis in Fibroblasts Transformed with Farnesylated but Not Geranylgeranylated H-RasDiana Brassard, Jessie M. English, Michael G. Malkowski, Paul T. Kirschmeier, Tattanahali L. Nagabhushan, Walter Robert Bishop · 2002 · Experimental Cell Research
- The Farnesyltransferase Inhibitor LB42708 Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signal PathwaysCK Kim, Yoon Kyung Choi, Hansoo Lee, Kwon‐Soo Ha, Moo‐Ho Won, Young‐Guen Kwon, Young-Myeong Kim · 2010 · Molecular Pharmacology
- Phosphorylation of RhoB by CK1 impedes actin stress fiber organization and epidermal growth factor receptor stabilizationVanessa Tillement, Isabelle Lajoie‐Mazenc, Anne Casanova, Carine Froment, Marie Pénary, Daniel Tovar, Rodolfo Márquez, Bernard Monsarrat, Gilles Favre, Anne Pradines · 2008 · Experimental Cell Research
- Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosisShuzhen Chen, Lei Fu, Shruti M. Raja, Ping Yue, Fadlo Raja Khuri, Shi‐Yong Sun · 2010 · Molecular Cancer
- CHEMOPREVENTIVE EFFICACY OF PROMISING FARNESYLTRANSFERASE INHIBITORSLaura E. Lantry, Zhongqiu Zhang, Keith A. Crist, Yian Wang, Mitsunobu Hara, Axel Zeeck, Ronald A. Lubet, Ming You · 2000 · Experimental Lung Research
- Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: Cleavage of the common α subunit during apoptosisKi Woo Kim, Hyun-Ho Chung, Chul-Woong Chung, In-Ki Kim, Masayuki Miura, Suyue Wang, Hong Zhu, Kyung-Duk Moon, Geun Bae Rha, Jy-Hyun Park et al. · 2001 · Oncogene
- Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cellsHang Zheng, Anling Liu, Bin Liu, Minghui Li, Hailang Yu, Xiaojun Luo · 2010 · Cancer Letters
- Caution! Analyze transcripts from conditional knockout allelesShao Hua Yang, Martin O. Bergö, Emily Farber, Xin Qiao, Loren G. Fong, Stephen G. Young · 2008 · Transgenic Research
- Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra®, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumoursWandena S. Siegel-Lakhai, Mirjam Crul, S. Zhang, Rolf W. Sparidans, Dick Pluim, Angela J. Howes, Bhavna Solanki, Jos H. Beijnen, Jan H.M. Schellens · 2005 · British Journal of Cancer
- Requirement for Geranylgeranyl Transferase I and Acyl Transferase in the TGF-β-Stimulated Pathway Leading to Elastin mRNA StabilizationUmberto Kucich, Joan C. Rosenbloom, Gloria Shen, William R. Abrams, Michelle A. Blaskovich, Andrew D. Hamilton, Junko Ohkanda, Saı̈d M. Sebti, Joel Rosenbloom · 1998 · Biochemical and Biophysical Research Communications
- O-082 A randomized phase III trial comparing ionafarnib/carboplatin/paclitaxel versus carboplatin/paclitaxel (CP) in chemotherapy-naive patients with advanced or metastatic non-small cell lung cancer (NSCLC)George R. Blumenschein, Carrianne Ludwig, G. Thomas, E. Tan, M. Fanucchi, Antonio Santoro, J. Crawford, Jean Luc Breton, M. O’Brien, Fadlo Raja Khuri · 2005 · Lung Cancer
- α-Subunit of Farnesyltransferase Is Phosphorylatedin Vivo:Effect of Protein Phosphatase-1 on Enzymatic ActivityAmit Kumar, Maureen H. Beresini, Punita Dhawan, Kamal D. Mehta · 1996 · Biochemical and Biophysical Research Communications
- Farnesyl transferase expression determines clinical response to the docetaxel‐lonafarnib combination in patients with advanced malignanciesJohn Sae Wook Kauh, Chantal Chanel‐Vos, Daniel Escuín, Michael Paul Fanucchi, Robert Donald Harvey, Nabil F. Saba, Dong Moon Shin, Anthony A. Gal, Lin Pan, Michael Kutner et al. · 2011 · Cancer
- Increased Farnesyltransferase Activity in Human Colorectal Cancer: Relationship with Clinicopathological Features and K-ras MutationMariangela Caruso, Maria Notarnicola, Maurizio Bifulco, Carmen Laezza, Guerra V., Donato F. Altomare, Vincenzo Memeo, Lorusso D., Ignazio Demma, Alfredo Di Leo · 2003 · Scandinavian Journal of Gastroenterology
- Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative diseaseAnna-Karin M. Sjogren, Karin Andersson, Omar M. Khan, Frida J. Olofsson, C. Karlsson, Martin O. Bergö · 2010 · Leukemia
- Protein geranylgeranyltransferase-I of Trypanosoma cruziKohei Yokoyama, J. Robert Gillespie, Wesley C. Van Voorhis A, Frederick S. Buckner A C, Michael H. Gelb · 2007 · Molecular and Biochemical Parasitology
- Chromatographic Assay and Peptide Substrate Characterization of Partially Purified Farnesyl- and Geranylgeranyltransferases from Rat Brain CytosolJean Albert Boutin, William Marande, Marion Goussard, Armelle Loynel, Emmanuel Canet, Jean‐Luc Fauchère · 1998 · Archives of Biochemistry and Biophysics
- p21ras farnesyltransferase α- and β-subunits are phosphorylated in PC-12 cells: TGF-β signaling pathway independent phosphorylationAmit Kumar, Kamal D. Mehta · 1997 · Neuroscience Letters
- The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrestHadas Reuveni, Shoshana Klein, Alexander Levitzki · 2003 · European Journal of Biochemistry
- Protease inhibitors prevent the protein kinase A-dependent loss of Rap1 GTPase from the particulate fraction of COS1 cellsCatherine J. Rundell, Claire E. Repellin, Stephen J. Yarwood · 2004 · Biochemical and Biophysical Research Communications
- Slaying RAS with a synthetic lethal weaponArchana Bommi‐Reddy, William G. Kaelin · 2010 · Cell Research
- posters F: Phase 1 and 2 studies2010 · Annals of Oncology