The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
DNMT3A in haematological malignancies
Open accessAbstract
DNA methylation patterns are disrupted in various malignancies, suggesting a role in the development of cancer, but genetic aberrations directly linking the DNA methylation machinery to malignancies were rarely observed, so this association remained largely correlative. Recently, however, mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) were reported in patients with acute myeloid leukaemia (AML), and subsequently in patients with various other haematological malignancies, pointing to DNMT3A as a critically important new tumour suppressor. Here, we review the clinical findings related to DNMT3A, tie these data to insights from basic science studies conducted over the past 20 years and present a roadmap for future research that should advance the agenda for new therapeutic strategies.
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Cited by
Differentiation therapy revisited
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Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies
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Metadata
- Authors
- Yang, L., Rau, R., & Goodell, M. A.
- Venue
- Nature Reviews Cancer
- Published
- 2015-02-19
- Volume
- 15
- Issue
- 3
- Pages
- 152-165
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2168342352
- Cited by
- 509
- References
- 25
- FWCI
- 10.15
- Type
- journal article
- Language
- en
- Open access
- green
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