Cardiovascular pharmacogenomics and individualized drug therapy
Open accessAbstract
The goal of individualized drug therapy requires physicians to be able to accurately predict an individual's response to a drug. Both genetic and environmental factors are known to influence drug response. 'Pharmacogenetics' is the study of the role of inheritance in variation in drug response phenotypes. Pharmacogenetics is now moving genome-wide to become 'pharmacogenomics', resulting in the recognition of novel biomarkers for individual variation in drug response. This article reviews the development, promise and challenges facing pharmacogenomics, using examples of drugs used to treat or prevent cardiovascular disease.
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Dose-response heterogeneity applies to the physiological decline associated with aging.
“Dose-response heterogeneity is not exclusive to pharmaceutical treatments; it is also applies to the physiological decline associated with aging [594].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [594]
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References 45 · Cited by 72
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- [42]Pei H FKBP51 acts as a scaffolding protein to regulate Akt phosphorylation Cancer Cell in press
- Authors
- Pereira, N. L., & Weinshilboum, R. M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Pereira, Naveen L.
- Venue
- Nature Reviews Cardiology
- Published
- 2009-08-25
- Volume
- 6
- Issue
- 10
- Pages
- 632-638
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- PMC
- PMC3108370
- OpenAlex
- W2019271482
- Cited by
- 72
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 11 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (U10HL084904, U01HL084904, HL 84904)
- National Cancer Institute (R01CA132780)
- National Institute of General Medical Sciences (U-01 GM61388, R01-GM-28157, U01GM061388, R01GM028157)
- National Center for Research Resources (UL1RR24150, UL1RR024150)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- pharmacogenetics, individualized drug therapy, drug response prediction, genetic variation in drug response, cardiovascular disease treatment, cardiovascular disease prevention, treatment response biomarkers
- MeSH terms
- Cardiovascular Agents, Cardiovascular Diseases, Genetic Testing, Genotype, Humans, Pedigree, Pharmacogenetics, Phenotype, Genetic Variation, Patient Selection, Precision Medicine
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