Cited by 1,063Genetic factors in colorectal cancerColorectal Cancer Treatments and StudiesColorectal Cancer Surgical Treatments

The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.

Microsatellite Instability in Colorectal Cancer-the Stable Evidence

Open access

Vilar, Eduardo, Gruber, Stephen B.·2010·Nature Reviews Clinical Oncology

DOI 10.1038/nrclinonc.2009.237PMC PMC3427139

Open this paper in CoChat — free account

Abstract

Microsatellite instability (MSI) is the molecular fingerprint of a deficient mismatch repair system. Approximately 15% of colorectal cancers (CRC) display MSI owing either to epigenetic silencing of MLH1 or a germline mutation in one of the mismatch repair genes MLH1, MSH2, MSH6 or PMS2. Methods to detect MSI are well established and routinely incorporated into clinical practice. A clinical and molecular profile of MSI tumors has been described, leading to the concept of an MSI phenotype in CRC. Studies have confirmed that MSI tumors have a better prognosis than microsatellite stable CRC, but MSI cancers do not necessarily have the same response to the chemotherapeutic strategies used to treat microsatellite stable tumors. Specifically, stage II MSI tumors might not benefit from 5-fluorouracil-based adjuvant chemotherapy regimens. New data suggest possible advantages of irinotecan-based regimens, but these findings require further clarification. Characterization of the molecular basis of MSI in CRC is underway and initial results show that mutations in genes encoding kinases and candidate genes with microsatellite tracts are over-represented in MSI tumors. Transcriptome expression profiles of MSI tumors and systems biology approaches are providing the opportunity to develop targeted therapeutics for MSI CRC.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrclinonc.2009.237

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
Vivanco, I., & Sawyers, C. L. (2002) · Nature reviews. Cancer · doi:10.1038/nrc839 · Cited by 6,155
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.
Boland, C. R., Thibodeau, S. N., Hamilton, S. R., Sidransky, D., Eshleman, J. R., Burt, R. W., Meltzer, S. J., Rodrı́guez-Bigas, M. A., Fodde, R., Ranzani, G. N., et al. (1998) · PubMed · Cited by 4,087
Genome maintenance mechanisms for preventing cancer
Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A. F., Powell, S. M., Riggins, G. J., et al. (2004) · Science · doi:10.1126/science.1096502 · Cited by 3,448
Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability
Umar, A., Boland, C. R., Terdiman, J. P., Syngal, S., de la Chapelle, A., Rüschoff, J., Fishel, R. A., Lindor, N. M., Burgart, L. J., Hamelin, R., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh034 · Cited by 3,181
Microsatellite Instability in Cancer of the Proximal Colon
Thibodeau, S. N., Bren, G. D., & Schaid, D. J. (1993) · Science · doi:10.1126/science.8484122 · Cited by 3,131
Systematic review and meta-analysis
Gillies, A. (2019) · CRC Press eBooks · doi:10.1201/9781315377315-19 · Cited by 2,876

Show all 100 references

Sorted by citations

Items 201–300 of 1,000

Emerging Role of Immunotherapy for Colorectal Cancer with Liver Metastasis
Yu, X., Zhu, L., Liu, J., Xie, M., Chen, J., & Li, J. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s271955 · Cited by 43
Clinical Genetics of Hereditary Colorectal Cancer
Power, D. G., Glogowski, E., & Lipkin, S. M. (2010) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2010.06.006 · Cited by 44
POLE proofreading mutation, immune response and prognosis in endometrial cancer
van Gool, I. C., Bosse, T., & Church, D. N. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1072675 · Cited by 43
Serrated colorectal cancer: preclinical models and molecular pathways
Aiderus, A., Barker, N., & Tergaonkar, V. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.09.011 · Cited by 42
Molecular Predictors of Response to Chemotherapy in Colorectal Cancer
Dienstmann, R., Vilar, E., & Tabernero, J. M. (2011) · The Cancer Journal · doi:10.1097/ppo.0b013e318212f844 · Cited by 43
Self-citation
MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity
Sheng, Y., Wong, K. Y., Seim, I., Wang, R., He, Y., Wu, A., Patrick, M., Lourie, R., Schreiber, V., Giri, R., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0951-y · Cited by 42
AGA Clinical Practice Update on Young Adult–Onset Colorectal Cancer Diagnosis and Management: Expert Review
Boardman, L. A., Vilar, E., You, Y. N., & Samadder, J. J. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.05.058 · Cited by 43
Self-citation
Colorectal Cancer: From Genetic Landscape to Targeted Therapy
Bali, M. E., Bakkach, J., & Mechita, M. B. (2021) · Journal of Oncology · doi:10.1155/2021/9918116 · Cited by 43
Cancer Therapy Guided by Mutation Tests: Current Status and Perspectives
Aleksakhina, S. N., & Imyanitov, E. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010931 · Cited by 41
Multi-omics of the gut microbial ecosystem in patients with microsatellite-instability-high gastrointestinal cancer resistant to immunotherapy
Cheng, S., Han, Z., Dai, D., Li, F., Zhang, X., Lu, M. S., Lü, Z., Wang, X., Zhou, J., Li, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101355 · Cited by 45
Epigenetic inactivation of the novel candidate tumor suppressor geneITIH5in colon cancer predicts unfavorable overall survival in the CpG island methylator phenotype
Kloten, V., Rose, M., Kaspar, S., von Stillfried, S. F., Knüchel, R., & Dahl, E. (2014) · Epigenetics · doi:10.4161/epi.32089 · Cited by 41
Molecular aspects of upper tract urothelial carcinoma
Patel, N. S., Arya, M., Muneer, A., Powles, T., Sullivan, M., Hines, J. E. W., & Kelly, J. D. (2013) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2012.10.002 · Cited by 41
Systematic genomic identification of colorectal cancer genes delineating advanced from early clinical stage and metastasis
Lee, H., Flaherty, P., & Ji, H. P. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-54 · Cited by 42
Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer
Chen, I.-C., Lee, K., Hsu, Y.-H., Wang, W., Chen, C., & Cheng, Y. (2016) · Disease Markers · doi:10.1155/2016/8169724 · Cited by 44
Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence
den Uil, S. H., Coupé, V. M. H., Linnekamp, J. F., van den Broek, E., Goos, J. A. C. M., Diemen, P. M. D., Belt, E. J. T., van Grieken, N. C. T., Scott, P. M., Vermeulen, L., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.376 · Cited by 41
BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations
Deihimi, S., Lev, A., Slifker, M. J., Shagisultanova, E. I., Xu, Q., Jung, K., Vijayvergia, N., Ross, E. A., Xiu, J., Swensen, J. J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18098 · Cited by 42
Impact of cancer evolution on immune surveillance and checkpoint inhibitor response
Wu, Y., Biswas, D., & Swanton, C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.02.013 · Cited by 43
Neoantigen: A Promising Target for the Immunotherapy of Colorectal Cancer
Zheng, Y., Fu, Y., Wang, P., & Ding, Z. (2022) · Disease Markers · doi:10.1155/2022/8270305 · Cited by 41
Ensemble transformer-based multiple instance learning to predict pathological subtypes and tumor mutational burden from histopathological whole slide images of endometrial and colorectal cancer
Wang, C., Liu, T.-C., Lai, P.-J., Muzakky, H., Wang, Y., Yu, M.-H., Wu, C.-H., & Chao, T. (2024) · Medical Image Analysis · doi:10.1016/j.media.2024.103372 · Cited by 41
Somatic gene mutations in African Americans may predict worse outcomes in colorectal cancer
Kang, M. S., Shen, X., Kim, S., Araújo-Pérez, F., Galanko, J. A., Martin, C. F., Sandler, R. S., & Keku, T. O. (2013) · Cancer Biomarkers · doi:10.3233/cbm-130366 · Cited by 40
The genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discovery
Hahn, M., de Voer, R. M., Hoogerbrugge, N., Ligtenberg, M. J. L., Kuiper, R. P., & van Kessel, A. G. (2016) · Cellular Oncology · doi:10.1007/s13402-016-0284-6 · Cited by 45
Is There a Role for Programmed Death Ligand-1 Testing and Immunotherapy in Colorectal Cancer With Microsatellite Instability? Part I—Colorectal Cancer: Microsatellite Instability, Testing, and Clinical Implications
Marginean, E. C., & Melosky, B. L. (2017) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2017-0040-ra · Cited by 40
Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis
Pamplona, R. S., Melas, M., Maoz, A., Schmit, S. L., Rennert, H. S., Lejbkowicz, F., Greenson, J. K., Sanjuán, X., López-Zambrano, M. A., Alonso, M. H., et al. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003292 · Cited by 40
Self-citation
Evolving insights: how DNA repair pathways impact cancer evolution
Zhou, J., Zhou, X. A., Zhang, N., & Wang, J. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0177 · Cited by 40
TP53 Mutation Infers a Poor Prognosis and Is Correlated to Immunocytes Infiltration in Breast Cancer
Zhang, Z., Hao, R., Guo, Q., Zhang, S., & Wang, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.759154 · Cited by 41
Clinico‐pathological factors influencing lymph node yield in colorectal cancer and impact on survival: Analysis of new zealand cancer registry data
Ahmadi, O., Stringer, M. D., Black, M. A., & McCall, J. L. (2015) · Journal of Surgical Oncology · doi:10.1002/jso.23848 · Cited by 40
Inflammation-Driven Genomic Instability: A Pathway to Cancer Development and Therapy Resistance
Rembiałkowska, N., Kocik, Z., Kłosińska, A., Kübler, M., Pałkiewicz, A., Rozmus, W., Sędzik, M., Wojciechowska, H., & Gajewska-Naryniecka, A. (2025) · Pharmaceuticals · doi:10.3390/ph18091406 · Cited by 42
Lynch or Not Lynch? Is that Always a Question?
Colas, C., Coulet, F., Svrcek, M., Collura, A., Fléjou, J., Duval, A., & Hamelin, R. (2012) · Advances in cancer research · doi:10.1016/b978-0-12-394280-7.00004-x · Cited by 42
Enhanced detection of microsatellite instability using pre-PCR elimination of wild-type DNA homo-polymers in tissue and liquid biopsies
Ladas, I., Yu, F., Leong, K. W., Fitarelli-Kiehl, M., Song, C., Ashtaputre, R. M., Kulke, M. H., Mamon, H. J., & Makrigiorgos, G. M. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky251 · Cited by 39
Implications of Hereditary Origin on the Immune Phenotype of Mismatch Repair-Deficient Cancers: Systematic Literature Review
Bohaumilitzky, L., Doeberitz, M. V. K., Kloor, M., & Ahadova, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061741 · Cited by 40
Distinctive genomic characteristics in POLE/POLD1-mutant cancers can potentially predict beneficial clinical outcomes in patients who receive immune checkpoint inhibitor
He, J.-J., Ouyang, W., Zhao, W., Shao, L., Li, B., Liu, B., Wang, D., Han‐Zhang, H., Zhang, Z., Shao, L., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-7553 · Cited by 39
Precancerous Lesions in Colorectal Cancer
Sandouk, F., Jerf, F. A., & Al-Halabi, M. H. D. B. (2013) · Gastroenterology Research and Practice · doi:10.1155/2013/457901 · Cited by 39
Clinical and Genetic Implications of DNA Mismatch Repair Deficiency in Biliary Tract Cancers Associated with Lynch Syndrome
Cloyd, J. M., Chun, Y. S., Ikoma, N., Vauthey, J., Aloia, T., Cuddy, A., Rodrı́guez-Bigas, M. A., & You, Y. N. (2017) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-017-0040-9 · Cited by 42
Epigenetic regulation of the intestinal epithelium
Elliott, E. N., & Kaestner, K. H. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1997-9 · Cited by 38
Prognostic value of microsatellite instability in sporadic locally advanced rectal cancer following neoadjuvant radiotherapy
Du, C., Zhao, J., Xue, W., Dou, F., & Gu, J. F. (2012) · Histopathology · doi:10.1111/his.12069 · Cited by 38
CHFR: a key checkpoint component implicated in a wide range of cancers
Sanbhnani, S., & Yeong, F. M. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0892-2 · Cited by 37
Examining the impact of gene variants on histone lysine methylation
Rechem, C. V., & Whetstine, J. R. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.014 · Cited by 37
A survey of tandem repeat instabilities and associated gene expression changes in 35 colorectal cancers
Sonay, T. B., Koletou, E., & Wagner, A. (2015) · BMC Genomics · doi:10.1186/s12864-015-1902-9 · Cited by 39
Integrating contextual miRNA and protein signatures for diagnostic and treatment decisions in cancer
Sempere, L. F. (2011) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.11.69 · Cited by 37
Leukocyte mitochondrial DNA content: a novel biomarker associated with prognosis and therapeutic outcome in colorectal cancer
Qu, F., Chen, Y., Wang, X., He, X., Ren, T., Huang, Q., Zhang, J., Liu, X., Guo, X., Gu, J. H., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv042 · Cited by 37
Association of mismatch repair status with survival and response to neoadjuvant chemo(radio)therapy in rectal cancer
Ye, S., Cheng, Y., Zhang, L., Zou, Y., Chen, P., Deng, Y., Huang, Y. Y., Peng, J., Wu, X., & Lan, P. (2020) · npj Precision Oncology · doi:10.1038/s41698-020-00132-5 · Cited by 37
Clinical actionability of triaging DNA mismatch repair deficient colorectal cancer from biopsy samples using deep learning
Wu, J., Mei, W.-J., Xu, S., Ling, Y., Li, W., Kuang, J.-B., Li, H., Hui, H., Li, J., Cai, M., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104120 · Cited by 40
Is Microsatellite Instability Really a Good Prognostic Factor of Colorectal Cancer?
Shin, U. S., Cho, S. S., Moon, S. M., Park, S. H., Jee, S. H., Jung, E.-J., & Hwang, D. (2014) · Annals of Coloproctology · doi:10.3393/ac.2014.30.1.28 · Cited by 37
Cellular and molecular events in colorectal cancer: biological mechanisms, cell death pathways, drug resistance and signalling network interactions
Yan, L., Shi, J. H., & Zhu, J. (2024) · Discover Oncology · doi:10.1007/s12672-024-01163-1 · Cited by 39
The intersection of homologous recombination (HR) and mismatch repair (MMR) pathways in DNA repair-defective tumors
Incorvaia, L., Russo, T. D. B., Gristina, V., Perez, A., Brando, C., Mujacic, C., Giovanni, E. D., Bono, M., Contino, S., Bannera, C. F., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00672-0 · Cited by 36
Genome-wide analysis associates familial colorectal cancer with increases in copy number variations and a rare structural variation at 12p12.3
Yang, R. K., Chen, B., Pfütze, K., Buch, S., Steinke, V., Holinski‐Feder, E., Stocker, S., Schönfels, W. V., Becker, T., Schackert, H. K., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt344 · Cited by 37
Lynch Syndrome: Genomics Update and Imaging Review
Cox, V. L., Bamashmos, A. S., Foo, W. C., Gupta, S., Yedururi, S., Garg, N., & Kang, H. C. (2018) · Radiographics · doi:10.1148/rg.2018170075 · Cited by 36
Immunohistochemical staining of cytokeratin 20 and cytokeratin 7 in colorectal carcinomas: Four different immunostaining profiles
Al-Maghrabi, J. A., Emam, E., & Gomaa, W. M. (2018) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_465_17 · Cited by 36
CD47 promotes the proliferation and migration of adamantinomatous craniopharyngioma cells by activating the MAPK/ERK pathway, and CD47 blockade facilitates microglia‐mediated phagocytosis
Zhang, H., Wang, C., Fan, J., Zhu, Q., Feng, Y., Pan, J., Peng, J., Shi, J., Qi, S., & Liu, Y. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12795 · Cited by 35
PFKP is a prospective prognostic, diagnostic, immunological and drug sensitivity predictor across pan-cancer
Peng, J. M., Li, P., Li, Y., Quan, J., Yao, Y., Duan, J., Liu, X., Li, H., Yuan, D., & Wang, X. (2023) · Scientific Reports · doi:10.1038/s41598-023-43982-2 · Cited by 36
Oncological characteristics, treatments and prognostic outcomes in MMR-deficient colorectal cancer
Fan, W., Su, F., Zhang, Y., Zhang, X., Du, Y., Gao, Y., Li, W., Hu, W., & Zhao, J. (2024) · Biomarker Research · doi:10.1186/s40364-024-00640-7 · Cited by 35
Comparison of the Mismatch Repair System between Primary and Metastatic Colorectal Cancers Using Immunohistochemistry
Jung, J., Kang, Y., Lee, Y. J., Kim, E., Ahn, B., Lee, E., Kim, J. Y., Lee, J. H., Lee, Y., Kim, C. H., et al. (2017) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2016.12.09 · Cited by 35
Screening of MSI detection loci and their heterogeneity in East Asian colorectal cancer patients
Bai, W., Ma, J., Liu, Y., Liang, J., Wu, Y., Yang, X., Xu, E., Li, Y., & Xi, Y. (2019) · Cancer Medicine · doi:10.1002/cam4.2111 · Cited by 35
High ANKZF1 Expression Is Associated With Poor Overall Survival And Recurrence-Free Survival In Colon Cancer
Zhou, X., Shang, Y., Lu, R., Fan, C., & Mo, X. (2019) · Future Oncology · doi:10.2217/fon-2018-0920 · Cited by 35
Microsatellite Instability in Colorectal Cancer Liquid Biopsy—Current Updates on Its Potential in Non-Invasive Detection, Prognosis and as a Predictive Marker
Tieng, F. Y. F., Abu, N., Lee, L., & Mutalib, N. A. (2021) · Diagnostics · doi:10.3390/diagnostics11030544 · Cited by 37
Immunology of Lynch Syndrome
Pastor, D. M., & Schlom, J. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01085-z · Cited by 38
Microsatellite and RAS/RAF Mutational Status as Prognostic Factors in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Tonello, M., Baratti, D., Sammartino, P., Giorgio, A. D., Robella, M., Sassaroli, C., Framarini, M., Valle, M., Macrì, A., Graziosi, L., et al. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-11045-3 · Cited by 35
High Red Cell Distribution Width Is Associated with Worse Prognosis in Early Colorectal Cancer after Curative Resection: A Propensity-Matched Analysis
Cheng, K., Lin, Y., Liu, C.-C., Wu, K., & Lee, K. (2022) · Cancers · doi:10.3390/cancers14040945 · Cited by 35
A review of the sensitivity of metastatic colorectal cancer patients with deficient mismatch repair to standard-of-care chemotherapy and monoclonal antibodies, with recommendations for future research
Wensink, G. E., Bond, M. J. G., Küçükköse, E., May, A. M., Vink, G. R., Koopman, M., Kranenburg, O., & Roodhart, J. M. L. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102174 · Cited by 35
Predicting colorectal cancer microsatellite instability with a self-attention-enabled convolutional neural network
Chang, X., Wang, J., Zhang, G., Yang, M., Xi, Y., Xi, C., Chen, G., Nie, X., Meng, B., & Quan, X. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100914 · Cited by 35
The parallel universe: microRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis
Haybaeck, J., & Zeller, N. (2011) · Swiss Medical Weekly · doi:10.4414/smw.2011.13287 · Cited by 34
No Evidence of Microsatellite Instability and Loss of Mismatch-Repair-Protein Expression in Squamous Cell Carcinoma of the Penis
Stoehr, R., Wendler, O., Giedl, J., Gaisa, N. T., Richter, G., Câmpean, V., Burger, M., Wullich, B., Bertz, S., & Hartmann, A. (2019) · Pathobiology · doi:10.1159/000495251 · Cited by 35
MSIsensor-ct: microsatellite instability detection using cfDNA sequencing data
Han, X., Zhang, S., Zhou, D. C., Wang, D., He, X., Yuan, D., Li, R., He, J., Duan, X., Wendl, M. C., et al. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa402 · Cited by 34
Pan-cancer analysis indicates that MYBL2 is associated with the prognosis and immunotherapy of multiple cancers as an oncogene
Chen, X., Lu, Y., Yu, H., Du, K., Zhang, Y., Yang, N., & Huang, Q. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1982494 · Cited by 34
A synopsis of modern - day colorectal cancer: Where we stand
Ranasinghe, R., Mathai, M. L., & Zulli, A. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188699 · Cited by 35
Lynch-like Syndrome: Potential Mechanisms and Management
Martínez‐Roca, A., Giner-Calabuig, M., Murcia, Ó., Castillejo, A., Soto, J. L., García‐Heredia, A., & Jover, R. (2022) · Cancers · doi:10.3390/cancers14051115 · Cited by 35
Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome
Raskin, L., Schwenter, F., Freytsis, M., Tischkowitz, M. D., Wong, N., Chong, G., Narod, S., Levine, D. A., Bogomolniy, F., Aronson, M. D., et al. (2010) · Clinical Genetics · doi:10.1111/j.1399-0004.2010.01594.x · Cited by 34
Self-citation
m6A methyltransferase METTL16 mediates immune evasion of colorectal cancer cells via epigenetically regulating PD-L1 expression
Wang, A., Sun, Y., Wang, X., Yan, Z., Wang, D., Zeng, L., & Lu, Q. (2023) · Aging · doi:10.18632/aging.204980 · Cited by 33
KRAS-targeted therapies in colorectal cancer: a systematic analysis of mutations, inhibitors, and clinical trials
Navarro-Jiménez, M., González, B., Mulet-Margalef, N., Hierro, C., & Alonso, S. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01166-3 · Cited by 38
Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians
Irabor, D., Oluwasola, O., Ogunbiyi, O. J., Ogun, G. O., Okolo, C. A., Melas, M., Gruber, S. B., Shi, C., & Raskin, L. (2017) · Anticancer Research · doi:10.21873/anticanres.11612 · Cited by 33
Self-citation
Diet, Microbiota, and Colorectal Cancer
Grazioso, T. P., Brandt, M., & Djouder, N. (2019) · iScience · doi:10.1016/j.isci.2019.10.011 · Cited by 37
Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome
Golubicki, M., Bonjoch, L., Acuña-Ochoa, J. G., Díaz‐Gay, M., Muñoz, J., Cuatrecasas, M., Ocaña, T., Iseas, S., Mendez, G. A., Cisterna, D., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.140698 · Cited by 33
DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology
Rahman, R. M., Shi, D. D., Reitman, Z. J., Hamerlik, P., de Groot, J., Haas-Kogan, D. A., D’Andrea, A. D., Sulman, E. P., Tanner, K. G., Agar, N. Y. R., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae072 · Cited by 34
The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis
Datorre, J. G., de Carvalho, A. C., Guimarães, D. P., & Reis, R. M. (2020) · Pathobiology · doi:10.1159/000512175 · Cited by 32
A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells
Cheng, A., Tian, X., You, W., Wang, T., Zhang, D., Guo, H., Zhang, H., Pan, X., Wang, Y., Liu, L., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00832-9 · Cited by 32
Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer
Zhang, J., Yan, B., Späth, S. S., Hu, Q., Cornelius, S., Guan, D., Shao, J., Hagiwara, K., Waes, C. V., Chen, Z., et al. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0043-9 · Cited by 32
Gene Expression Variations in Microsatellite Stable and Unstable Colon Cancer Cells
Duldulao, M. P., Lee, W., Le, M. N., Chen, Z., Li, W., Wang, J., Gao, H., Li, H., Kim, J., & García‐Aguilar, J. (2011) · Journal of Surgical Research · doi:10.1016/j.jss.2011.06.016 · Cited by 33
Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance
Esposito, A., Agostini, A., Quero, G., Piro, G., Priori, L., Caggiano, A., Scaglione, G., Battaglia, A., Calegari, M. A., Salvatore, L., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07266-5 · Cited by 32
PD-L1 is a double-edged sword in colorectal cancer: the prognostic value of PD-L1 depends on the cell type expressing PD-L1
Ho, H., Chou, T., Yang, S.-H., Jiang, J., Chen, W.-S., Chao, Y., & Teng, H. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-02942-y · Cited by 31
Novel Epigenetic Eight-Gene Signature Predictive of Poor Prognosis and MSI-Like Phenotype in Human Metastatic Colorectal Carcinomas
Condelli, V., Calice, G., Cassano, A., Basso, M., Rodriquenz, M. G., Zupa, A., Maddalena, F., Crispo, F., Pietrafesa, M., Aieta, M., et al. (2021) · Cancers · doi:10.3390/cancers13010158 · Cited by 31
The WRN helicase: resolving a new target in microsatellite unstable cancers
van Wietmarschen, N., Nathan, W. J., & Nussenzweig, A. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2021.06.014 · Cited by 32
Playing With Dynamite? A Cautious Assessment of TNT
Shi, D. D., & Mamon, H. J. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.02199 · Cited by 31
In situ tuning proangiogenic factor-mediated immunotolerance synergizes the tumoricidal immunity via a hypoxia-triggerable liposomal bio-nanoreactor
Chen, C., Zhang, S., Zhang, R., Sun, P., Shi, C., Abdalla, M., Li, A., Xu, J., Du, W., Zhang, J., et al. (2020) · Theranostics · doi:10.7150/thno.50806 · Cited by 30
SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1
Tian, C., Lang, T., Qiu, J., Han, K., Zhou, L., Min, D., Zhang, Z., & Qi, D. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01683-0 · Cited by 30
Intratumoral spatial heterogeneity of tumor-infiltrating lymphocytes is a significant factor for precisely stratifying prognostic immune subgroups of microsatellite instability-high colorectal carcinomas
Jung, M., Lee, J. A., Yoo, S., Bae, J. M., Kang, G. H., & Kim, J. H. (2022) · Modern Pathology · doi:10.1038/s41379-022-01137-0 · Cited by 30
Polycythemia vera and essential thrombocythemia in young patients.
Frezzato, M., Ruggeri, M., Castaman, G., & Rodeghiero, F. (1993) · PubMed · Cited by 30
Corrigendum: Combination of T-Cell Bispecific Antibodies With PD-L1 Checkpoint Inhibition Elicits Superior Anti-Tumor Activity
Sam, J., Colombetti, S., Fauti, T., Roller, A., Biehl, M., Fahrni, L., Nicolini, V., Perro, M., Nayak, T. K., Bommer, E., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.650149 · Cited by 30
Development of Molecular Biomarkers in Individualized Treatment of Colorectal Cancer
Mattos‐Arruda, L. D., Dienstmann, R., & Tabernero, J. M. (2011) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2011.03.030 · Cited by 30
Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients
Frydendahl, A., Kassentoft, C. G., Knudsen, M., Laursen, M. B., Madsen, A. H., Iversen, L. H., Gotschalck, K. A., Rasmussen, M. H., & Andersen, C. L. (2019) · BMC Cancer · doi:10.1186/s12885-019-6227-7 · Cited by 29
TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer
Yang, M., Huang, Q., Li, C., Jiang, Z., Sun, J. P., Wang, Z., Liang, R., Li, D., Li, B., & Zhao, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.647540 · Cited by 29
Therapeutic Targets of KRAS in Colorectal Cancer
Rahman, S., Garrel, S., Gerber, M., Maitra, R., & Goel, S. (2021) · Cancers · doi:10.3390/cancers13246233 · Cited by 28
Viroimmunotherapy for Colorectal Cancer: Clinical Studies
Chaurasiya, S., & Warner, S. G. (2017) · Biomedicines · doi:10.3390/biomedicines5010011 · Cited by 28
Identifying Optimal Loci for the Molecular Diagnosis of Microsatellite Instability
Long, D. R., Waalkes, A., Panicker, V., Hause, R. J., & Salipante, S. J. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa177 · Cited by 28
Pembrolizumab in unresectable or metastatic MSI-high colorectal cancer: safety and efficacy
Roth, M., & Das, S. (2020) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2021.1851201 · Cited by 28
Genetic-Based Biomarkers and Next-Generation Sequencing: The Future of Personalized Care in Colorectal Cancer
Kim, R. Y., Xu, H., Myllykangas, S., & Ji, H. P. (2011) · Personalized Medicine · doi:10.2217/pme.11.16 · Cited by 28
Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study
Ismael, N. E. H. S., Sheikh, S. A. E., Talaat, S. M., & Salem, E. M. (2017) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2017.003 · Cited by 28
DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer
Ricker, C. N., Hanna, D. L., Peng, C., Nguyen, N. T., Stern, M. C., Schmit, S. L., Idos, G. E., Patel, R., Tsai, S. C., Ramirez, V., et al. (2017) · Cancer · doi:10.1002/cncr.30790 · Cited by 28
Hereditary cancer syndromes: utilizing DNA repair deficiency as therapeutic target
Goyal, G., Fan, T., & Silberstein, P. T. (2016) · Familial Cancer · doi:10.1007/s10689-016-9883-7 · Cited by 28
Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures
Chitwood, D. G., Wang, Q., Elliott, K. S., Bullock, A., Jordana, D., Li, Z., Wu, C. H., Harcum, S. W., & Saski, C. A. (2021) · BMC Biotechnology · doi:10.1186/s12896-020-00667-2 · Cited by 27
PD-L1 as a Prognostic Factor in Early-Stage Colon Carcinoma within the Immunohistochemical Molecular Subtype Classification
Azcue, P., Encı́o, I., Setas, D. G., Suárez, J., Galbete, A., Mercado, M., Vera, R., & Dorronsoro, M. L. G. (2021) · Cancers · doi:10.3390/cancers13081943 · Cited by 28

Authors: Vilar, E., & Gruber, S. B.
Affiliations: University of Michigan (US)
Corresponding author: Gruber, Stephen B.
ORCID: Vilar, Eduardo
Gruber, Stephen B.
Venue: Nature Reviews Clinical Oncology
Publisher: Springer Science and Business Media LLC
Published: 2010-02-09
Volume: 7
Issue: 3
Pages: 153-162
ISSN: 1759-4774 (ISSN-L)
1759-4782
DOI: 10.1038/nrclinonc.2009.237
PMC: PMC3427139
OpenAlex: W2050658928
Cited by: 1,063
References: 100
Citations by year: 2026: 57 · 2025: 100 · 2024: 116 · 2023: 114 · 2022: 99 · 2021: 81 · 2020: 75 · 2019: 65 · 2018: 66 · 2017: 46 · 2016: 34 · 2015: 47 · 2014: 44 · 2013: 44 · 2012: 28
FWCI: 4.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (5P30 CA 46592, 1R01CA81488, R01CA081488, P30CA046592)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Keywords: microsatellite instability, colorectal cancer, mismatch repair deficiency, prognosis, predictive biomarkers, irinotecan, kinase mutations, targeted therapy
MeSH terms: DNA Repair, Humans, Colorectal Neoplasms, Germ-Line Mutation, DNA Repair Enzymes, Microsatellite Instability

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microsatellite Instability in Colorectal Cancer-the Stable Evidence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks