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Exercise rehabilitation in patients with cancer
Open accessAbstract
Emerging evidence indicates that patients with cancer have considerable impairments in cardiorespiratory fitness, which is likely to be a result of the direct toxic effects of anticancer therapy as well as the indirect consequences secondary to therapy (for example, deconditioning). This reduced cardiorespiratory fitness is associated with heightened symptoms, functional dependence, and possibly with an increased risk of cardiovascular morbidity and mortality. Current understanding of the complex interaction between the effects of the tumour and cancer-associated therapies on the organ components that govern cardiorespiratory fitness, and the effects of exercise training on these parameters is limited; further research will be critical for further progress of exercise-based rehabilitation in the oncology setting. We assess the current evidence regarding the level, mechanisms, and clinical importance of diminished cardiorespiratory fitness in patients with cancer. The efficacy and adaptations to exercise training to prevent and/or mitigate dysfunction in conjunction with exercise prescription considerations for clinical use are also discussed.
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“Aerobic exercise during adjuvant chemotherapy does not appear to stimulate greater production of red blood cells(92), so improvements in cardiorespiratory fitness are contingent on other central (i.e., cardiac function, plasma volume) and peripheral adaptations (i.e., improved vascularization and mitochondrial enzyme function)(93).”
From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [93]
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Metadata
- Authors
- Lakoski, S. G., Eves, N. D., Douglas, P. S., & Jones, L. W.
- Affiliations
- University of British Columbia (CA)
- Duke University (US)
- Corresponding author
- Jones, Lee W.
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2012-03-06
- Volume
- 9
- Issue
- 5
- Pages
- 288-296
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- PMC
- PMC3640332
- OpenAlex
- W2002193164
- Cited by
- 165
- References
- 66
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 18 · 2021: 10 · 2020: 16 · 2019: 18 · 2018: 11 · 2017: 9 · 2016: 13 · 2015: 19 · 2014: 11 · 2013: 10 · 2012: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA133895, R21CA143254, CA138634, R01CA138624, CA-143254, CA125458, R01CA138634, R21CA133895, R01CA142566, CA-142566, R21CA125458)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- exercise rehabilitation, cancer patients, cardiorespiratory fitness, supervised exercise, deconditioning, cardiovascular morbidity, exercise prescription, functional dependence
- MeSH terms
- Adaptation, Physiological, Exercise Therapy, Humans, Neoplasms
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