Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

Cites (240)

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3. Antibody-Mediated Inhibition of Fibroblast Growth Factor 19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys
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5. Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
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6. Plasma FGF21 displays a circadian rhythm during a 72‐h fast in healthy female volunteers
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9. Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice
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14. Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation
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15. FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein
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19. Regulation of Amphiregulin Gene Expression by β-Catenin Signaling in Human Hepatocellular Carcinoma Cells: A Novel Crosstalk between FGF19 and the EGFR System
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21. A Better Anti-Diabetic Recombinant Human Fibroblast Growth Factor 21 (rhFGF21) Modified with Polyethylene Glycol
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26. Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
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27. Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion
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28. SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells
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29. A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog
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31. FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress
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32. Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice
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36. Hepatocyte FRS2α is Essential for the Endocrine Fibroblast Growth Factor to Limit the Amplitude of Bile Acid Production Induced by Prandial Activity
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37. The Sum of All Browning in FGF21 Therapeutics
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38. Klotho spins the thread of life--what does Klotho do to the receptors of fibroblast growth factor-23 (FGF23)?
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39. Biologists abandon Popper at their peril
    2000