Twenty years on: the impact of fragments on drug discovery

Cited by (1,000)

Items 301–400 of 1,000

1. Drugging the Undruggable: Targeting Challenging E3 Ligases for Personalized Medicine
   Carles Galdeano · 2017 · Future Medicinal Chemistry
2. Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitors
   Ziquan Zhao, Ruitian Dong, Qidong You, Zhengyu Jiang · 2023 · Journal of Medicinal Chemistry
3. Fragment-based drug nanoaggregation reveals drivers of self-assembly
   Chen Chen, You Ping Wu, Shih‐Ting Wang, Naxhije Berisha, Mandana Taghizadeh Manzari, Kristen C. Vogt, Oleg Gang, Daniel A. Heller · 2023 · Nature Communications
4. 19F-NMR in Target-based Drug Discovery
   CongBao Kang · 2019 · Current Medicinal Chemistry
5. E3 Ubiquitin Ligases: Key Regulators of TGFβ Signaling in Cancer Progression
   Abhishek Sinha, Prasanna Vasudevan Iyengar, Peter ten Dijke · 2021 · International Journal of Molecular Sciences
6. Discovery of a Cell‐Active SuTEx Ligand of Prostaglandin Reductase 2
   Emmanuel K. Toroitich, Anthony M. Ciancone, Heung Sik Hahm, Skylar M. Brodowski, Adam H. Libby, Ku‐Lung Hsu · 2021 · ChemBioChem
7. Pseudonatural Products Occur Frequently in Biologically Relevant Compounds
   José‐Manuel Gally, Axel Pahl, Paul Czodrowski, Herbert Waldmann · 2021 · Journal of Chemical Information and Modeling
8. Comprehensive analysis of commercial fragment libraries
   Julia Revillo Imbernon, Célien Jacquemard, Guillaume Bret, Gilles Marcou, Esther Kellenberger · 2021 · RSC Medicinal Chemistry
9. Recent advances in DNA-encoded dynamic libraries
   Bingbing Shi, Yu Zhou, Xiaoyu Li · 2022 · RSC Chemical Biology
10. Biophysical screening in fragment-based drug design: a brief overview
    Jacob Robson‐Tull · 2018 · Bioscience Horizons The International Journal of Student Research
11. Fluorine NMR functional screening: from purified enzymes to human intact living cells
    Claudio Dalvit, Marina Veronesi, Anna Vulpetti · 2020 · Journal of Biomolecular NMR
12. Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies
    Lossouarn, Alexis, Renard, Pierre-Yves, Sabot, Cyrille · 2021 · Bioconjugate Chemistry
13. Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning
    G.J. Correy, Moira M. Rachman, Takaya Togo, Stefan Gahbauer, Yagmur Umay Doruk, Maisie GV Stevens, Priyadarshini Jaishankar, Brian P. Kelley, Brian B. Goldman, Molly Schmidt et al. · 2025 · Science Advances
14. cat-ELCCA: catalyzing drug discovery through click chemistry
    Amanda L. Garner · 2018 · Chemical Communications
15. Using Fragment-Based Approaches to Discover New Antibiotics
    Bas Lamoree, Roderick E. Hubbard · 2018 · SLAS DISCOVERY
16. Computational and Experimental Druggability Assessment of Human DNA Glycosylases
    Maurice Michel, Torkild Visnes, Evert J. Homan, Brinton A. Seashore-Ludlow, Mattias Hedenström, Elisée Wiita, Karl S. A. Vallin, Cynthia B. J. Paulin, Jiaxi Zhang, Olov A. Wallner et al. · 2019 · ACS Omega
17. The 3F Library: Fluorinated Fsp3‐Rich Fragments for Expeditious 19F NMR Based Screening
    Nikolaj S. Troelsen, Elena Shanina, Diego González‐Romero, Daniela Danková, Ida S. A. Jensen, Katarzyna J. Śniady, Faranak Nami, Hengxi Zhang, Christoph Rademacher, Ana Cuenda et al. · 2019 · Angewandte Chemie
18. A Practical Perspective on the Roles of Solution NMR Spectroscopy in Drug Discovery
    Qingxin Li, CongBao Kang · 2020 · Molecules
19. Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
    S.E. Thomas, Andrew Whitehouse, Karen Brown, Sophie Burbaud, Juan M. Belardinelli, Jasper Sangen, Ramanuj Lahiri, M. Daben J. Libardo, Pooja Gupta, Sony Malhotra et al. · 2020 · Nucleic Acids Research
20. Non-hydroxamate inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR): A critical review and future perspective
    Sharyu Kesharwani, Sandeep Sundriyal · 2020 · European Journal of Medicinal Chemistry
21. Applications of Solution NMR in Drug Discovery
    Shi Li, Naixia Zhang · 2021 · Molecules
22. Small-Molecule Lead-Finding Trends across the Roche and Genentech Research Organizations
    Peter S. Dragovich, Wolfgang J. Haap, Melinda M. Mulvihill, Jean‐Marc Plancher, Antonia F. Stepan · 2022 · Journal of Medicinal Chemistry
23. Virtual screening and molecular dynamics simulation approach for the identification of potential multi-target directed ligands for the treatment of Alzheimer’s disease
    Kailash Jangid, Bharti Devi, Ashrulochan Sahoo, Vijay Kumar, Ashish Ranjan Dwivedi, Suresh Thareja, Rajnish Kumar, Vinod Kumar · 2023 · Journal of Biomolecular Structure and Dynamics
24. From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking
    Emira J. Visser, Priyadarshini Jaishankar, Eline Sijbesma, Marloes A. M. Pennings, Edmee M. F. Vandenboorn, X. Guillory, R. Jeffrey Neitz, John Kenneth Morrow, Shubhankar Dutta, Adam R. Renslo et al. · 2023 · Angewandte Chemie International Edition
25. Partial filling affinity capillary electrophoresis as a useful tool for fragment-based drug discovery: A proof of concept on thrombin
    Elena Farcaş, Charlotte Bouckaert, Anne‐Catherine Servais, Julien Hanson, Lionel Pochet, Marianne Fillet · 2017 · Analytica Chimica Acta
26. Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors
    Lucile Lecas, Lucie Hartmann, Lydia N. Caro, Sarah Bouteben, Claire Raingeval, Isabelle Krimm, Renaud Wagner, Vincent Dugas, Claire Demesmay · 2020 · Analytica Chimica Acta
27. Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions
    Ahmed M. Shawky, Faisal A. Almalki, Hayat Ali Alzahrani, Ashraf N. Abdalla, Bahaa G. M. Youssif, Nashwa A. Ibrahim, Mohammed Gamal, Hany A.M. El-Sherief, Maha M. Abdel‐Fattah, Ahmed A. Hefny et al. · 2024 · European Journal of Medicinal Chemistry
28. Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach
    Chao Zhao, Dane Huang, Ruyue Li, Yida Xu, Shimin Su, Qiong Gu, Jun Xu · 2019 · Journal of Medicinal Chemistry
29. Fragment Binding Pose Predictions Using Unbiased Simulations and Markov-State Models
    Stephanie Maria Linker, Aniket Magarkar, Jürgen Köfinger, Gerhard Hummer, Daniel Seeliger · 2019 · Journal of Chemical Theory and Computation
30. Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects
    Yunyuan Huang, Lin Wei, Xinya Han, Haifeng Chen, Yanliang Ren, Yanhong Xu, Rongrong Song, Li Rao, Su Chen, Chao Peng et al. · 2019 · European Journal of Medicinal Chemistry
31. Targeting Epigenetic protein–protein Interactions With small-molecule Inhibitors
    Brian M. Linhares, Jolanta E. Grembecka, Tomasz Cierpicki · 2020 · Future Medicinal Chemistry
32. An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
    Samuel Harry Myers, Laura Poppi, Francesco Rinaldi, Marina Veronesi, Andrea Ciamarone, Viola Previtali, Greta Bagnolini, Fabrizio Schipani, Jose Antonio Ortega Martínez, Stefania Girotto et al. · 2023 · European Journal of Medicinal Chemistry
33. Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni
    Lauro Ribeiro de Souza Neto, Bogar O. Araujo-Montoya, J. Brandão-Neto, Anil Kumar Verma, Sebastian Bowyer, José Teófilo Moreira‐Filho, Rafael Ferreira Dantas, Bruno Junior Neves, Carolina Horta Andrade, F. von Delft et al. · 2024 · Scientific Reports
34. Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modelling
    David A. Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia‐Borràs, Kendall N. Houk, Rudi Fasan · 2024 · Nature Chemistry
35. Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders
    Charis Georgiou, Iain W. McNae, Martin A. Wear, Harris Ioannidis, Julien Michel, Malcolm D. Walkinshaw · 2017 · Journal of Molecular Biology
36. A Computer Vision Approach to Align and Compare Protein Cavities: Application to Fragment-Based Drug Design
    Merveille Eguida, Didier Rognan · 2020 · Journal of Medicinal Chemistry
37. Computer-Aided Analysis of Multiple SARS-CoV-2 Therapeutic Targets: Identification of Potent Molecules from African Medicinal Plants
    Franklyn Nonso Iheagwam, Solomon O. Rotimi · 2020 · Scientifica
38. Fragment-Based Lead Discovery
    Ben J. Davis, Stephen D. Roughley · 2017 · Annual reports in medicinal chemistry
39. How to Find a Fragment: Methods for Screening and Validation in Fragment‐Based Drug Discovery
    Tim Kirkman, Catharina dos Santos Silva, Manuela Tosin, M.V.B. Dias · 2024 · ChemMedChem
40. Selective targeting of epigenetic reader domains
    Holger Greschik, Roland Schüle, Thomas Günther · 2017 · Expert Opinion on Drug Discovery
41. Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities
    Davide Moiani, Daryl A. Ronato, Chris A. Brosey, Andrew S. Arvai, Aleem Syed, Jean‐Yves Masson, Elena Petricci, John A. Tainer · 2018 · Methods in enzymology on CD-ROM/Methods in enzymology
42. Applications of Dissolution-DNP for NMR Screening
    Yaewon Kim, Christian Hilty · 2018 · Methods in enzymology on CD-ROM/Methods in enzymology
43. Development of ERK1/2 inhibitors as a therapeutic strategy for tumour with MAPK upstream target mutations
    Longfei Miao, Hongqi Tian · 2019 · Journal of drug targeting
44. Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library
    Yu Zhou, Wenyin Shen, Jianzhao Peng, Yuqing Deng, Xiaoyu Li · 2021 · Bioorganic & Medicinal Chemistry
45. Fragment-based design of selective GPCR ligands guided by free energy simulations
    Pierre G. Matricon, Duc Duy Vo, Zhan‐Guo Gao, Jan O. Kihlberg, Kenneth A. Jacobson, Jens Carlsson · 2021 · Chemical Communications
46. Pseudo Natural Products—Chemical Evolution of Natural Product Structure
    George Karageorgis, Daniel J. Foley, Luca Laraia, Susanne Brakmann, Herbert Waldmann · 2021 · Angewandte Chemie
47. Implementing a Scoring Function Based on Interaction Fingerprint for Autogrow4: Protein Kinase CK1δ as a Case Study
    Matteo Pavan, Silvia Menin, Davide Bassani, Mattia Sturlese, Stefano Moro · 2022 · Frontiers in Molecular Biosciences
48. Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments
    Radosław Kitel, Ismael Rodríguez, Xabier del Corte, Jack Atmaj, Magdalena Żarnik, Ewa Surmiak, Damian Muszak, Katarzyna Magiera‐Mularz, Grzegorz M. Popowicz, Tad A. Holak et al. · 2022 · ACS Chemical Biology
49. Advances of bioorthogonal coupling reactions in drug development
    Feiyan Zhan, Jingjie Zhu, Shaowen Xie, Jinyi Xu, Shengtao Xu · 2023 · European Journal of Medicinal Chemistry
50. Rational Design in Photopharmacology with Molecular Photoswitches
    Piermichele Kobauri, Frank J. Dekker, Wiktor Szymański, Ben L. Feringa · 2023 · Angewandte Chemie
51. Nature-inspired and medicinally relevant short peptides
    Maria Gessica Ciulla, Monica Civera, Sara Sattin, Kamal Kumar · 2023 · Exploration of Drug Science
52. Recent developments of P-glycoprotein inhibitors and its structure–activity relationship (SAR) studies
    Xuanming Zhao, Jing Di, Dingjie Luo, Yogesh Vaishnav, kamal kamal, Nargiza Nuralieva, Payal Verma, Payal Verma, Shekhar Verma · 2023 · Bioorganic Chemistry
53. Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries
    Yu Zhou, Wenyin Shen, Ying Gao, Jianzhao Peng, Qingrong Li, Xueying Wei, Shihao Liu, Fong Sang Lam, Joan Mayol-Llinàs, Guixian Zhao et al. · 2024 · Nature Chemistry
54. Biophysics: for HTS hit validation, chemical lead optimization, and beyond
    Christine C. Genick, S. Kirk Wright · 2017 · Expert Opinion on Drug Discovery
55. Global Discovery of Covalent Modulators of Ribonucleoprotein Granules
    Anthony M. Ciancone, Kyung Won Seo, Miaomiao Chen, Adam L. Borne, Adam H. Libby, Dina L. Bai, Ralph E. Kleiner, Ku‐Lung Hsu · 2023 · Journal of the American Chemical Society
56. Fragment-based drug discovery: A graphical review
    Dana F. AlKharboush, Frank Kozielski, Geoffrey Wells, Exequiel O. J. Porta · 2025 · Current Research in Pharmacology and Drug Discovery
57. Molecular-Simulation-Driven Fragment Screening for the Discovery of New CXCL12 Inhibitors
    Gerard Martinez-Rosell, M J Harvey, Gianni De Fabritiis · 2018 · Journal of Chemical Information and Modeling
58. Small-Molecule Screening for Genetic Diseases
    Sarine Markossian, Kenny K. H. Ang, Christopher G. M. Wilson, Michelle R. Arkin · 2018 · Annual Review of Genomics and Human Genetics
59. Efficient affinity ranking of fluorinated ligands by 19F NMR: CSAR and FastCSAR
    Simon Rüdisser, Nils Goldberg, Marc‐Olivier Ebert, Helena Kovacs, Alvar D. Gossert · 2020 · Journal of Biomolecular NMR
60. A Computational Workflow for the Identification of Novel Fragments Acting as Inhibitors of the Activity of Protein Kinase CK1δ
    Giovanni Bolcato, Eleonora Cescon, Matteo Pavan, Maicol Bissaro, Davide Bassani, Stephanie Federico, Giampiero Spalluto, Mattia Sturlese, Stefano Moro · 2021 · International Journal of Molecular Sciences
61. Hydrogen/Deuterium Exchange Mass Spectrometry for Weak Binders
    Yoshitomo Hamuro, Stephen J. Coales · 2022 · Journal of the American Society for Mass Spectrometry
62. Targeting ER-Mitochondria Signaling as a Therapeutic Target for Frontotemporal Dementia and Related Amyotrophic Lateral Sclerosis
    Sandra M. Martín‐Guerrero, Andrea Markovinović, Gábor M. Mórotz, Shaakir Salam, Wendy J. Noble, Christopher C.J. Miller · 2022 · Frontiers in Cell and Developmental Biology
63. Fragment-Based Drug Discovery against Mycobacteria: The Success and Challenges
    Namdev S. Togre, Ana M. Vargas, Gunapati Bhargavi, Mohan Krishna Mallakuntla, Sangeeta Tiwari · 2022 · International Journal of Molecular Sciences
64. Deconstructing Lipid Kinase Inhibitors by Chemical Proteomics
    Rebecca L. McCloud, Caroline E. Franks, Sean Campbell, Benjamin W. Purow, Thurl E. Harris, Ku‐Lung Hsu · 2017 · Biochemistry
65. Heterocyclic iodoniums as versatile synthons to approach diversified polycyclic heteroarenes
    Daqian Zhu, Zhouming Wu, Liyun Liang, Yameng Sun, Bingling Luo, Peng Huang, Shijun Wen · 2019 · RSC Advances
66. Advancing Design Strategy of PROTACs for Cancer Therapy
    Hang Luo, Yuan Tian, Razack Abdullah, Bao‐Ting Zhang, Yuan Ma, Ge Zhang · 2025 · MedComm
67. Binding thermodynamics discriminates fragments from druglike compounds: a thermodynamic description of fragment-based drug discovery
    Glyn Williams, György G. Ferenczy, Johan Ulander, György Miklós Keserű · 2016 · Drug Discovery Today
68. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
    Sarah L. Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias J. Krojer et al. · 2020 · Chemical Science
69. Structural and molecular bases to IRE1 activity modulation
    Timothy Langlais, Diana Pelizzari‐Raymundo, Sayyed Jalil Mahdizadeh, Nicolas Gouault, François Carreaux, Éric Chevet, Leif Axel Eriksson, X. Guillory · 2021 · Biochemical Journal
70. Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking
    A. Metz, J. Wollenhaupt, Steffen Glöckner, Niki Messini, Simon Huber, Tatjana Barthel, Ahmed Merabet, Hans‐Dieter Gerber, A. Heine, Gerhard Klebe et al. · 2021 · Acta Crystallographica Section D Structural Biology
71. Fragment-Based Approaches to Identify RNA Binders
    Blessy M. Suresh, Amirhossein Taghavi, Jessica L. Childs‐Disney, Matthew David Disney · 2023 · Journal of Medicinal Chemistry
72. Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis
    João Augusto Ribeiro, Alexander J. S. Hammer, Gerardo Andrés Libreros-Zúñiga, S.M. Chavez-Pacheco, Petros A. Tyrakis, Gabriel Stephani de Oliveira, Timothy Kirkman, Jamal El Bakali, Silvana Aparecida Rocco, Mauricio Luis Sforça et al. · 2020 · ACS Infectious Diseases
73. Dual-locked fluorescent probes for precise diagnosis and targeted treatment of tumors
    Tang Gao, Can Xiang, Xintao Ding, Mingxing Xie · 2024 · Heliyon
74. Insights into Structures and Dynamics of Flavivirus Proteases from NMR Studies
    Qingxin Li, CongBao Kang · 2020 · International Journal of Molecular Sciences
75. Many small steps towards a COVID-19 drug
    Daniel A. Erlanson · 2020 · Nature Communications
76. Targeting the ubiquitin system by fragment-based drug discovery
    Cassandra R. Kennedy, Katherine A. McPhie, Katrin Rittinger · 2022 · Frontiers in Molecular Biosciences
77. Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery
    Manjuan Liu, Amin R. Mirza, Craig McAndrew, Arjun Thapaliya, Olivier A. Pierrat, Mark Stubbs, Tamas Hahner, Nicola E. A. Chessum, Paolo Innocenti, John Caldwell et al. · 2023 · Journal of Medicinal Chemistry
78. Binding mode information improves fragment docking
    Célien Jacquemard, Malgorzata N. Drwal, Jérémy Desaphy, Esther Kellenberger · 2019 · Journal of Cheminformatics
79. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors
    Resmi C. Panicker, Souvik Chattopadhaya, Anthony G. Coyne, Rajavel Srinivasan · 2019 · Advances in experimental medicine and biology
80. Synthesis of N‐Carbonyl Acridanes as Highly Potent Inhibitors of Tubulin Polymerization via One‐Pot Copper‐Catalyzed Dual Arylation of Nitriles with Cyclic Diphenyl Iodoniums
    Xiaopeng Peng, Ling Li, Yichang Ren, Huanxin Xue, Jin Liu, Shijun Wen, Jianjun Chen · 2020 · Advanced Synthesis & Catalysis
81. Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (M PRO ) through in silico screening supported by molecular docking and a fragment-based pharmacophore model
    Lucas Silva Franco, Rodolfo do Couto Maia, Eliezer J. Barreiro · 2020 · RSC Medicinal Chemistry
82. Exhaustive Repertoire of Druggable Cavities at Protein–Protein Interfaces of Known Three-Dimensional Structure
    Franck Da Silva, Guillaume Bret, Leandro Dias Teixeira, Claudio F. González, Didier Rognan · 2019 · Journal of Medicinal Chemistry
83. Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease
    Jun Ping Quek, Shuang Liu, Zhenzhen Zhang, Yan Li, Elizabeth Yihui Ng, Ying Ru Loh, Alvin W. Hung, Dahai Luo, CongBao Kang · 2020 · Antiviral Research
84. Protein–fragment complex structures derived by NMR molecular replacement
    Felix Torres, Dhiman Ghosh, Dean Strotz, N. Celestine, Ben J. Davis, Julien Orts · 2020 · RSC Medicinal Chemistry
85. Using NMR Spectroscopy in the Fragment‐Based Drug Discovery of Small‐Molecule Anticancer Targeted Therapies
    Benjamín Diethelm‐Varela · 2020 · ChemMedChem
86. Puckering the Planar Landscape of Fragments: Design and Synthesis of a 3D Cyclobutane Fragment Library
    David J. Cole Hamilton, Marieke Beemsterboer, Caroline M. Carter, Jasmina Elsayed, Rilana E. M. Huiberts, Hanna F. Klein, Peter O’Brien, Iwan J. P. de Esch, Maikel Wijtmans · 2022 · ChemMedChem
87. Applications of “linkers” in fragment-based drug design
    Xin Tao Wu, Yuan Zhang, Songbin Liu, Chang Liu, Guotao Tang, Xuan Cao, Xiaoyong Lei, Junmei Peng · 2022 · Bioorganic Chemistry
88. Target-Focused Library Design by Pocket-Applied Computer Vision and Fragment Deep Generative Linking
    Merveille Eguida, Christel Valencia-Schmitt, Marcel Hibert, Pascal Villa, Didier Rognan · 2022 · Journal of Medicinal Chemistry
89. Advancing small-molecule drug discovery by encoded dual-display technologies
    Alice Lessing, Dimitar D. Petrov, Jörg Scheuermann · 2023 · Trends in Pharmacological Sciences
90. Fragment‐based drug discovery as alternative strategy to the drug development for neglected diseases
    Juliana da Fonseca Rezende e Mello, Renan Augusto Gomes, Drielli Gomes Vital, Gláucio Monteiro Ferreira, Gustavo Henrique Goulart Trossini · 2017 · Chemical Biology & Drug Design
91. Mass spectrometry for fragment screening
    Daniel Shiu‐Hin Chan, Andrew Whitehouse, Anthony G. Coyne, Chris Abell · 2017 · Essays in Biochemistry
92. NAOMInext – Synthetically feasible fragment growing in a structure-based design context
    Kai Sommer, Florian Flachsenberg, Matthias Rarey · 2018 · European Journal of Medicinal Chemistry
93. Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production
    Srinivas Chamakuri, Prashi Jain, Shiva Krishna Reddy Guduru, J. Winston Arney, Kevin R. MacKenzie, Conrad Santini, Damian W. Young · 2018 · The Journal of Organic Chemistry
94. Chemical Intuition in Drug Design and Discovery
    Júlia G. B. Pedreira, Lucas Silva Franco, Eliezer J. Barreiro · 2019 · Current Topics in Medicinal Chemistry
95. Development of a Web-Based Laboratory Class to Reduce the Challenges in Teaching Fragment-Based Drug Design
    Xing-Xing Shi, Jing-Yi Li, Qiong Chen, Xiao‐Lei Zhu, Ge‐Fei Hao, Guang‐Fu Yang · 2020 · Journal of Chemical Education
96. The QSAR Paradigm in Fragment-Based Drug Discovery: From the Virtual Generation of Target Inhibitors to Multi-Scale Modeling
    Valeria V. Kleandrova, Alejandro Speck‐Planche · 2020 · Mini-Reviews in Medicinal Chemistry
97. Pharmacophore-guided fragment-based design of novel mammalian target of rapamycin inhibitors: extra precision docking, fingerprint-based 2D and atom-based 3D-QSAR modelling
    Avinash Kumar, Sudhanshu Rai, Ekta Rathi, Paridhi Agarwal, Suvarna G. Kini · 2020 · Journal of Biomolecular Structure and Dynamics
98. Installation of an aryl boronic acid function into the external section of -aryl-oxazolidinones: Synthesis and antimicrobial evaluation
    Cristina D. Cruz, Pauli J. Wrigstedt, Karina Moslova, Vladimir Iashin, Heidi Mäkkylä, Léo Ghemtio, Sami Heikkinen, Päivi Tammela, Jesús E. Perea‐Buceta · 2020 · European Journal of Medicinal Chemistry
99. Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments
    Francesca Fata, Ilaria Silvestri, Matteo Ardini, Rodolfo Ippoliti, Luana Di Leandro, Nicola Demitri, Maurizio Polentarutti, Adele Di Matteo, Haining Lyu, Gregory R. J. Thatcher et al. · 2021 · ACS Infectious Diseases
100. Generation of Polar Semi‐Saturated Bicyclic Pyrazoles for Fragment‐Based Drug‐Discovery Campaigns.
     Nicola Luise, Paul Graham Wyatt · 2018 · Chemistry - A European Journal