Carbohydrate vaccines: developing sweet solutions to sticky situations?
Open accessAbstract
Recent technological advances in glycobiology and glycochemistry are paving the way for a new era in carbohydrate vaccine design. This is enabling greater efficiency in the identification, synthesis and evaluation of unique glycan epitopes found on a plethora of pathogens and malignant cells. Here, we review the progress being made in addressing challenges posed by targeting the surface carbohydrates of bacteria, protozoa, helminths, viruses, fungi and cancer cells for vaccine purposes.
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Polysaccharide processing and presentation by the MHCII pathway
Cobb, B. A., Wang, Q., Tzianabos, A. O., & Kasper, D. L. (2004) · Cell · doi:10.1016/j.cell.2004.05.001 · Cited by 340 · see citing works
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Sialic acids sweeten a tumor's life
Büll, C., Stoel, M. A., den Brok, M. H., & Adema, G. J. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0728 · Cited by 496 · see citing works
Sweet escape: Sialic acids in tumor immune evasion
Büll, C., den Brok, M. H., & Adema, G. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.07.005 · Cited by 158 · see citing works
Carbohydrate-Based Vaccines: An Overview
Hütter, J., & Lepenies, B. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2874-3_1 · Cited by 55 · see citing works
- Authors
- Astronomo, R. D., & Burton, D. R.
- Affiliations
- Scripps Research Institute (US)
- Venue
- Nature Reviews Drug Discovery
- Published
- 2010-04
- Volume
- 9
- Issue
- 4
- Pages
- 308-324
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC3878310
- OpenAlex
- W2087585684
- Cited by
- 629
- References
- 1
- Citations by year
- 2026: 21 · 2025: 40 · 2024: 25 · 2023: 31 · 2022: 42 · 2021: 38 · 2020: 48 · 2019: 43 · 2018: 38 · 2017: 42 · 2016: 41 · 2015: 62 · 2014: 44 · 2013: 33 · 2012: 38
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- International AIDS Vaccine Initiative
- Natural Sciences and Engineering Research Council of Canada
- National Institute of Allergy and Infectious Diseases (R37AI033292)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- carbohydrate vaccines, carbohydrate epitopes, vaccine design, bacterial surface carbohydrates, protozoan parasites, helminths, viral glycosylation, fungal glycosylation, cancer glycosylation, glycochemistry, glycobiology, glycan synthesis, antibiotic resistance
- MeSH terms
- Animals, Epitopes, Carbohydrates, Glycoconjugates, Humans, Polysaccharides, Vaccines, Drug Design, Drug Delivery Systems, Glycomics
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