Phase II and Phase III attrition rates 2011–2012

Arrowsmith, John, Miller, Philip·2013·Nature Reviews Drug Discovery

Cited by (697)

Items 501–600 of 697

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  10. Nonclinical Safety Assessment: An Introduction for Statisticians
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    Jesús Zurdo, Andreas Arnell, Olga Obrezanova, Noel Smith, Thomas R. A. Gallagher, Ramón Gómez de la Cuesta, Ben Locwin · 2015 · CRC Press eBooks
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  16. Minds Open : Sustainability of the European regulatory system for medicinal products
    Hoebert, Vonk Raa, van de Laar Cwe · 2014 · Rivm (National Institute for Public Health and the Environment)
  17. A unique multiattribute method to predict success of emerging drug targets
    Sangeetha De, Linda Meredith · 2015 · Drug Discovery Today
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  20. Drug Target Identification and Validation
    Srinivas Gullapalli · 2021 · Springer eBooks
  21. Current and Future Strategies for Improving Drug Discovery Efficiency
    Peter Njogu, Kelly Chibale · 2015
  22. Emerging Technologies and their Role in Regulatory Review
    Thomas J. Colatsky · 2016
  23. Is the Microbiome the Fifth Horseman of the Apocalypse in Drug Discovery? Implications for the Gut–Brain Axis
    Joseph A. Conrad, Craig W. Lindsley · 2017 · ACS Chemical Neuroscience
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  27. The importance of 3D cell culture in drug discovery and development
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  28. A data-driven journey using results from target-based drug discovery for target deconvolution in phenotypic screening
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  39. Translational research in drug discovery — current issues and perspectives
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  41. Using Human Pluripotent Stem Cell-Derived Neural Cultures to Assess Safety of New Drugs and Chemicals
    Cassiano Carromeu · 2018 · InTech eBooks
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    R.G. Hill · 2013 · Physiology News
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    Saurabh Sharma, J Kumaravel, Gurjeet Kaur, Ajay Prakash, Bikash Medhi · 2023 · Elsevier eBooks
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  58. Can Innovation Still Be the Main Growth Driver of the Pharmaceutical Industry?
    Alexander Schuhmacher · 2014 · Perspectives on sustainable growth
  59. Comment offrir à tous un accès aux thérapeutiques innovantes ?
    Jacques L. Cadranel, Perrine Créquit, Thibault Vieira, Anne-Marie Ruppert, Valérie Gounant, A. Lavolé, Marie Wislez · 2015 · Revue des Maladies Respiratoires Actualités
  60. The art and science of the drug discovery pipeline
    William Loging · 2016 · Cambridge University Press eBooks
  61. Preclinical Cancer Models with the Potential to Predict Clinical Response
    Martin Scherzer, Nina Kramer, Christine Unger, Angelika Walzl, Stefanie Walter, Mira Stadler, Markus Hengstschläger, Helmut Dolznig · 2016 · Elsevier eBooks
  62. Using Systems Pharmacology to Advance Oncology Drug Development
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  63. Non-clinical efficacy-related studies for human medicines: An overview and retrospective analysis of data for a group of approved medicines
    A.C. de Mirandae Figueiredo · 2017 · Regulatory Toxicology and Pharmacology
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  65. Computational Drug Target Tractability Analysis
    Andrew R. Leach, Chris J. Radoux · 2019 · Elsevier eBooks
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  68. A Unidirectional 96-Well Fluidic Culture Platform for Upstream Cell Dosing with Subsequent Downstream Nonlinear and Ascending Exposure Gradients for Real-Time and Cell-Based Toxicity Screening Environments
    Bincy Anu John, David J. Sloan, Timothy C. Jensen · 2021 · Applied In Vitro Toxicology
  69. Transparency in Non-Technical Project Summaries to Promote the Three Rs in Respiratory Disease Research
    Martina Bonassera, Esther Clews, Kelly BéruBé · 2022 · Alternatives to Laboratory Animals
  70. When I use a word . . . Commercial clinical trials
    Jeffrey K Aronson · 2023 · BMJ
  71. Emerging Data Strengthens the Argument That the Microbiome Is the Fifth Horseman of the Drug Discovery Apocalypse
    Craig W. Lindsley · 2017 · ACS Chemical Neuroscience
  72. A statistical framework for assessing pharmacological response and biomarkers using uncertainty estimates
    Dennis Y.Q. Wang, James Hensman, Ginte Kutkaite, Tzen S. Toh, GDSC Screening Team, Jonathan R Dry, Julio Sáez-Rodríguez, Mathew J. Garnett, Michael P. Menden, Frank Dondelinger · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Label‐Free Techniques for Target Discovery and Validation
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  74. Brain-to-Plasma Concentration Ratio and Unbound Partition Coefficient
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  75. Brain-to-Plasma Concentration Ratio and Unbound Partition Coefficient
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  76. A Machine Learning and Bioinformatic Analysis Reveals an Associated between Cell Surface Receptor Transcript Levels with Drug Response of Breast Cancer Cells and the Drug Off-Target Effects
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  77. Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients
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  78. Testing of putative antiseizure drugs in a preclinical Dravet syndrome zebrafish model
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  80. Prédiction des constantes cinétiques de complexes protéine-ligand
    Sonia Ziada · 2019
  81. Getting Our ACT Together
    Katrina Gore, Phil Stanley · 2015 · Significance
  82. La sépiaptérine réductase
    Alban Latrémolière · 2016 · médecine/sciences
  83. High-throughput analysis of kinase inhibitor drugs on cardiac function using engineered heart tissue constructs
    Genevieve Conant, Zhao Yimu, Milica Radisic · 2016 · Frontiers in Bioengineering and Biotechnology
  84. Pers P ective sP ecial Focus: Horizons in Medicinal cH e M istry
    Asfar Sohail Azmi · 2014
  85. Bioinspired matrices for in vitro hepatic differentiation
    Liisa K. Kanninen · 2016 · Työväentutkimus Vuosikirja
  86. Causal Inference in Medicine via Mendelian Randomization
    Timothy M. Frayling, Benjamin F. Voight · 2016 · Springer eBooks
  87. Regulatory perspective on the use of lung imaging in drug development
    Laura Fregonese · 2015 · European Respiratory Society eBooks
  88. ADME Properties Leading to Toxicity
    Katya Tsaioun · 2016
  89. Contemporary Considerations for Discovering a Successful Medicine
    Michael M. Hann, Martin K. Bayliss, Andrew R. Leach · 2016 · Elsevier eBooks
  90. How to improve success rates of the compounds acting on CNS using biomarkers.
    S. Katsumata · 2017 · Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  91. Flipping the odds of drug development success through human genomics
    Aroon Dinesh Hingorani, Valerie Kuan, Chris Finan, Felix Alexander Krüger, Anna Gaulton, Sandesh Chopade, Reecha Sofat, Raymond J. MacAllister, John P. Overington, Harry Hemingway et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  92. Microfluidic Device for Co-culturing Lung Airway Cells on a Suspended Hydrogel: Towards a Biomimetic Lung Airway Model
    Mouhita Humayun · 2016 · TSpace (University of Toronto)
  93. Development of in vitro Drug Screening Platforms Using Human Induced Pluripotent Stem Cell-Derived Cardiovascular Cells
    Yosuke K. Kurokawa · 2017 · Open Scholarship Institutional Repository (Washington University in St. Louis)
  94. Recent Progress and Prospect of Drug Metabolism/Pharmacokinetics Research Contributing to Drug Development
    Tsuyoshi Yokoi, Shingo Oda · 2017 · KAGAKU TO SEIBUTSU
  95. Toxicology Meets Pharmacodynamics and Pharmacokinetics – New Concepts, Models and In Vitro Approaches and Tools
    Tuula Heinonen, Olavi Pelkonen, Hanna Tähti · 2018 · Basic & Clinical Pharmacology & Toxicology
  96. Addressing Genotoxicity Risk in Lead Optimization: A PDE10A Inhibitor Case Study
    Bie M. P. Verbist, Marjolein Crabbe, Freddy Van Goethem · 2018 · Methods and principles in medicinal chemistry
  97. The Integrated Optimization of Safety and DMPK Properties Enabling Preclinical Development: A Case History with S1P 1 Agonists
    Simon Taylor · 2018 · Methods and principles in medicinal chemistry
  98. Future Needs in Issue Resolution of Problems That Arise in Drug Development
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  99. Step II: Target Validation
    Pierfausto Seneci · 2018 · Elsevier eBooks
  100. Introduction to Issue Resolution
    Mary Jeanne Kallman · 2018 · Elsevier eBooks