mRNA-based therapeutics--developing a new class of drugs

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Items 601–700 of 1,005

1. mRNA vaccines in the context of cancer treatment: from concept to application
   Qiang Fu, Xiaoming Zhao, Jinxia Hu, Yang Jiao, Yunfei Yan, Xuchen Pan, Xin Wang, Fei Jiao · 2025 · Journal of Translational Medicine
2. Synthetic biology devices and circuits for RNA-based ‘smart vaccines’: a propositional review
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3. Clinical translation of gene medicine
   Fazhan Wang, Zhou Qin, Hansi Lu, Siyan He, Jing Cong Luo, Chaohui Jin, Xiangrong Song · 2019 · The Journal of Gene Medicine
4. Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery
   Kingshuk Dutta, Ritam Das, Jewel Medeiros, S. Thayumanavan · 2021 · Biochemistry
5. Detecting emerging technologies and their evolution using deep learning and weak signal analysis
   Ashkan Ebadi, Alain Auger, Yvan Gauthier · 2022 · Journal of Informetrics
6. Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination
   Aurélien Sokal, Paul Bastard, Pascal Chappert, Giovanna Barba Spaeth, Slim Fourati, Alexis Vandenberghe, Pauline Lagouge-Roussey, Isabelle Meyts, Adrian Gervais, Magali Bouvier‐Alias et al. · 2022 · The Journal of Experimental Medicine
7. Potential health risks of mRNA-based vaccine therapy: A hypothesis
   Karina A. Acevedo‐Whitehouse, Roxana Bruno · 2023 · Medical Hypotheses
8. Design of bacteriophage T4-based artificial viral vectors for human genome remodeling
   Jingen Zhu, Himanshu Batra, Neeti Ananthaswamy, Marthandan Mahalingam, Tao Pan, Xiaorong Wu, Wenzheng Guo, Andrei Fokine, Venigalla Basaveswara Rao · 2023 · Nature Communications
9. Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery
   Pei Huang, Hongzhang Deng, Changrong Wang, Yongfeng Zhou, Xiaoyuan Shawn Chen · 2023 · Advanced Materials
10. Progress in Neoantigen Targeted Cancer Immunotherapies
    Xuejiao Han, Xuelei Ma, Yang Li, Yu-quan Wei, Yong Peng, Xiawei Wei · 2020 · Frontiers in Cell and Developmental Biology
11. An RNA/DNA hybrid origami-based nanoplatform for efficient gene therapy
    Xiaohui Wu, Qing Lin Liu, Fengsong Liu, Tiantian Wu, Yingxu Shang, Jianbing Liu, Baoquan Ding · 2021 · Nanoscale
12. LipoParticles: Lipid-Coated PLA Nanoparticles Enhanced In Vitro mRNA Transfection Compared to Liposomes
    Camille Ayad, Pierre Libeau, Céline Lacroix, Catherine Ladavière, Bernard Verrier · 2021 · Pharmaceutics
13. Poly‐Adenine‐Based Spherical Nucleic Acids for Efficient Live‐Cell MicroRNA Capture
    Kai Jiao, Qinglong Yan, Linjie Guo, Zhibei Qu, Shuting Cao, Xiaoliang Chen, Qian Li, Ying Jie Zhu, Jiang Li, Lihua Wang et al. · 2021 · Angewandte Chemie International Edition
14. mRNA delivery in cancer immunotherapy
    Yichen Zhong, Shi Du, Yizhou Dong · 2023 · Acta Pharmaceutica Sinica B
15. Messenger RNA-Based Therapeutics and Vaccines: What’s beyond COVID-19?
    Dongqiao Li, Cynthia Liu, Yingzhu Li, Rumiana Tenchov, Janet M. Sasso, Di Zhang, Dan Li, Lixue Zou, Xuezhao Wang, Qiongqiong Angela Zhou · 2023 · ACS Pharmacology & Translational Science
16. Characterization of mRNA therapeutics
    Guilherme J. Guimaraes, Jaeah Kim, Michael G. Bartlett · 2023 · Mass Spectrometry Reviews
17. Computational design of mRNA vaccines
    Yoo-Ah Kim, Kambiz Mousavi, A Khalili Yazdi, Magdalena Zwierzyna, Marco Cardinali, Dillion M. Fox, Thomas Peel, Jeff Coller, Kunal Aggarwal, Giulietta Maruggi · 2023 · Vaccine
18. Ionizable Amino Lipids Distribution and Effects on DSPC/Cholesterol Membranes: Implications for Lipid Nanoparticle Structure
    Sepehr Dehghani‐Ghahnaviyeh, Michael Smith, Yan Xia, Athanasios D. Dousis, Alan M. Grossfield, Sreyoshi Sur · 2023 · The Journal of Physical Chemistry B
19. Nanomechanical action opens endo-lysosomal compartments
    Yu Zhao, Zhongfeng Ye, Donghui Song, Douglas Wich, Shuliang Gao, Jennifer Khirallah, Qiaobing Xu · 2023 · Nature Communications
20. mRNA-LNP COVID-19 Vaccine Lipids Induce Complement Activation and Production of Proinflammatory Cytokines: Mechanisms, Effects of Complement Inhibitors, and Relevance to Adverse Reactions
    Tamás Bakos, Tamás Mészáros, Gergely Tibor Kozma, Petra Berényi, Réka Facskó, Henriette Farkas, László Dézsi, Carlo Heirman, Stefaan De Koker, Raymond Michel Schiffelers et al. · 2024 · International Journal of Molecular Sciences
21. Cytoplasmic mRNA decay and quality control machineries in eukaryotes
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22. Exogenous RNA surveillance by proton-sensing TRIM25
    Myeonghwan Kim, Youngjoon Pyo, Seong‐In Hyun, Minseok Jeong, Yeon Choi, V. Narry Kim · 2025 · Science
23. Nucleic Acid Delivery by Solid Lipid Nanoparticles Containing Switchable Lipids: Plasmid DNA vs. Messenger RNA
    Itziar Gómez-Aguado, Julen Rodríguez-Castejón, Mónica Vicente-Pascual, Alicia Rodríguez‐Gascón, Ana del Pozo‐Rodríguez, Maria Ángelés Solinís · 2020 · Molecules
24. Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis
    John H. Lockhart, Jeffrey VanWye, Richa Banerjee, Samuel A. Wickline, Hua Pan, Hana Totary-Jain · 2021 · Molecular Therapy
25. Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications
    Skylar T. Chuang, Brandon Conklin, Joshua B. Stein, George Pan, Ki‐Bum Lee · 2022 · Nano Convergence
26. Principles for optimization and validation of mRNA lipid nanoparticle vaccines against COVID-19 using 3D bioprinting
    Massimiliano Papi, Daniela Pozzi, Valentina Palmieri, Giulio Caracciolo · 2022 · Nano Today
27. RNA-based drugs and regulation: Toward a necessary evolution of the definitions issued from the European union legislation
    Mathieu Guerriaud, Évelyne Kohli · 2022 · Frontiers in Medicine
28. Oligonucleotide mapping via mass spectrometry to enable comprehensive primary structure characterization of an mRNA vaccine against SARS-CoV-2
    Brian C. Gau, Andrew Dawdy, Hanliu Leah Wang, Bradley Bare, Carlos H. Castaneda, Olga V. Friese, Matthew S. Thompson, Thomas F. Lerch, David J. Cirelli, Jason C. Rouse · 2023 · Scientific Reports
29. Polyplex designs for improving the stability and safety of RNA therapeutics
    Satoshi Uchida, Chun Yin Jerry Lau, Makoto Oba, Kanjiro Miyata · 2023 · Advanced Drug Delivery Reviews
30. The Platform Technology Approach to mRNA Product Development and Regulation
    John H. Skerritt, C L Tucek, Brett A Sutton, Terry M. Nolan · 2024 · Vaccines
31. The dynamic process of mRNA delivery by lipid nanoparticles in vivo
    Runpu Ma, Yuting Li, Yi Wei, Juanjuan Zhou, Jinya Ma, Mengke Zhang, Junyi Tu, Jinhong Jiang, Sitao Xie, Weihong Tan et al. · 2024 · Nano Today
32. Characterisation and analysis of mRNA critical quality attributes using liquid chromatography based methods
    Alexandra L.J. Webb, Emma N. Welbourne, Caroline A. Evans, Mark J. Dickman · 2025 · Journal of Chromatography A
33. Apolipoprotein Fusion Enables Spontaneous Functionalization of mRNA Lipid Nanoparticles with Antibody for Targeted Cancer Therapy
    Wonbeom Park, Jiwoong Choi, Jaehyeon Hwang, Su Hyun Kim, Yelee Kim, Man Kyu Shim, Wooram Park, Seokhyeon Yu, Sangwon Jung, Yoosoo Yang et al. · 2025 · ACS Nano
34. Nebulisation of IVT mRNA Complexes for Intrapulmonary Administration
    Sarah M. Johler, Joanna Rejman, Shan Guan, Joseph Rosenecker · 2015 · PLoS ONE
35. mRNA Cancer Vaccines—Messages that Prevail
    Christian R. Grunwitz, Lena M. Kranz · 2017 · Current topics in microbiology and immunology
36. Transfection by cationic gemini lipids and surfactants
    Mark Damen, A. Groenen, Stijn F. M. van Dongen, Roeland J. M. Nolte, Bob J. Scholte, Martinus C. Feiters · 2018 · MedChemComm
37. Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor
    Chin‐Yu Lin, Samuel Thomas Crowley, Satoshi Uchida, Yuji Komaki, Kazunori Kataoka, Keiji Itaka · 2019 · Molecular Therapy — Nucleic Acids
38. Reductive Decationizable Block Copolymers for Stimuli-Responsive mRNA Delivery
    Lutz Nuhn, Leonard Kaps, Mustafa Diken, Detlef Schuppan, Rudolf Zentel · 2016 · Macromolecular Rapid Communications
39. Noncationic Material Design for Nucleic Acid Delivery
    Ziwen Jiang, S. Thayumanavan · 2020 · Advanced Therapeutics
40. Self-amplifying mRNA-Based Vaccine Technology and Its Mode of Action
    Giulietta Maruggi, Jeffrey B. Ulmer, Rino Rappuoli, Dong Liang Yu · 2021 · Current topics in microbiology and immunology
41. Toward rational vaccine engineering
    Yashavantha L. Vishweshwaraiah, Nikolay V. Dokholyan · 2022 · Advanced Drug Delivery Reviews
42. mRNA Vaccines: Why Is the Biology of Retroposition Ignored?
    Tomislav Domazet‐Lošo · 2022 · Genes
43. Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer
    Neelkanth Manoj Bardhan · 2022 · MRS Communications
44. mRNA: Vaccine or Gene Therapy? The Safety Regulatory Issues
    Hélène Banoun · 2023 · International Journal of Molecular Sciences
45. RNA-based translation activators for targeted gene upregulation
    Yang Cao, Huachun Liu, Shannon S. Lu, Krysten A. Jones, Anitha P. Govind, Okunola Jeyifous, Christine Q. Simmons, Negar Tabatabaei, William N. Green, Jimmy Lloyd Holder et al. · 2023 · Nature Communications
46. Modulating Lipid Nanoparticles with Histidinamide‐Conjugated Cholesterol for Improved Intracellular Delivery of mRNA
    Onesun Jung, Hye‐youn Jung, Lê Thị Thanh Thủy, Minyoung Choi, Seongyeon Kim, Hae‐Geun Jeon, Jihyun Yang, Seok‐Min Kim, Tae‐Don Kim, Eunjung Lee et al. · 2024 · Advanced Healthcare Materials
47. Crown-like Biodegradable Lipids Enable Lung-Selective mRNA Delivery and Dual-Modal Tumor Imaging In Vivo
    Zhaoming Chen, Yuexia Yang, Xinyu Qiu, Hao Zhou, Rui Wang, Hu Xiong · 2024 · Journal of the American Chemical Society
48. Zika Virus Vaccine Development
    Kaitlyn M. Morabito, Barney S. Graham · 2017 · The Journal of Infectious Diseases
49. Fluorescence Correlation Spectroscopy to find the critical balance between extracellular association and intracellular dissociation of mRNA complexes
    Heyang Zhang, Stefaan C. De Smedt, Katrien Remaut · 2018 · Acta Biomaterialia
50. Improving Cancer Vaccine Efficiency by Nanomedicine
    Junyu Cai, Hao Wang, Dangge Wang, Yaping Li · 2019 · Advanced Biosystems
51. Therapy Development by Genome Editing of Hematopoietic Stem Cells
    Lola Koniali, Carsten Werner Lederer, Marina Kleanthous · 2021 · Cells
52. The potential of RNA-based therapy for kidney diseases
    Tjessa Bondue, Lambertus P. van den Heuvel, Elena N. Levtchenko, Roland E. Brock · 2022 · Pediatric Nephrology
53. Nanoparticles in clinical trials of COVID-19: An update
    Abdur Rauf, Tareq Abu‐Izneid, Anees Ahmed Khalil, Nabia Hafeez, Ahmed Olatunde, Md. Mominur Rahman, Prabhakar Semwal, Yahya Saleh Al-Awthan, Omar Salem Bahattab, Ishaq Nasib Khan et al. · 2022 · International Journal of Surgery
54. Vaccines ‘on demand’: science fiction or a future reality
    Jeffrey B. Ulmer, Monique K. Mansoura, Andrew J. Geall · 2015 · Expert Opinion on Drug Discovery
55. mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognition
    Röltgen, Katharina, Nielsen, Sandra C. A., Arunachalam, Prabhu S., Yang, Fan, Hoh, Ramona A., Wirz, Oliver F., Lee, Alexandra S., Gao, Fei, Mallajosyula, Vamsee, Li, Chunfeng et al. · 2021
56. RNA Interference and Nanotechnology: A Promising Alliance for Next Generation Cancer Therapeutics
    Guruprasadh Swaminathan, Aisha Shigna Nadukkandy, Aviral Kumar, Vishnu Vardhan Byroju, Varsha Reddy Durgempudi, Lekha Dinesh Kumar · 2021 · Frontiers in Nanotechnology
57. Efficient Gene Silencing in Intact Plant Cells Using siRNA Delivered By Functional Graphene Oxide Nanoparticles
    Shuojun Li, Jiaying Li, Moqing Du, Guiyun Deng, Zhiyong Song, Heyou Han · 2022 · Angewandte Chemie International Edition
58. Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances
    Japhette Esther Kembou-Ringert, Dieter Steinhagen, John Readman, Janet M. Daly, Mikołaj Adamek · 2023 · Vaccines
59. Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA
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60. Synthesis of oligonucleotides on a soluble support
    Harri Lönnberg · 2017 · Beilstein Journal of Organic Chemistry
61. RNA Therapeutics: How Far Have We Gone?
    Maria Francisca Coutinho, Liliana Matos, Juliana Inês Santos, Sandra Alves · 2019 · Advances in experimental medicine and biology
62. Fluorescence‐Based Quantification of Messenger RNA and Plasmid DNA Decay Kinetics in Extracellular Biological Fluids and Cell Extracts
    Heyang Zhang, Koen Rombouts, Laurens Raes, Ranhua Xiong, Stefaan C. De Smedt, Kevin Braeckmans, Katrien Remaut · 2020 · Advanced Biosystems
63. Efficient Delivery of mRNA Using Crosslinked Nucleic Acid Nanogel as a Carrier
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64. Intravenous Delivery of RNA Encoding Anti-PD-1 Human Monoclonal Antibody for Treating Intestinal Cancer
    Lipei Wu, Weiwei Wang, Jiale Tian, Chunrun Qi, Zhengxin Cai, Wenhui Yan, Shihai Xuan, Anquan Shang · 2022 · Journal of Cancer
65. Fine-tuning of polyaspartamide derivatives with alicyclic moieties for systemic mRNA delivery
    Jongmin Yum, Beob Soo Kim, Satomi Ogura, Rimpei Kamegawa, Mitsuru Naito, Yuichi Yamasaki, Hyun Jin Kim, Kanjiro Miyata · 2022 · Journal of Controlled Release
66. Chemically Modified mocRNAs for Highly Efficient Protein Expression in Mammalian Cells
    Abhishek J. Aditham, Hailing Shi, Jianting Guo, Hu Zeng, Yiming Zhou, Sarah D. Wade, Jiahao Huang, Jia Liu B, Xiao Wang · 2022 · ACS Chemical Biology
67. Chemical modifications to mRNA nucleobases impact translation elongation and termination
    Monika K. Franco, Kristin S. Koutmou · 2022 · Biophysical Chemistry
68. RNA Therapeutics: the Next Generation of Drugs for Cardiovascular Diseases
    Nada Bejar, Trinh To Tat, Dániel Kiss · 2022 · Current Atherosclerosis Reports
69. Engineered mRNA Delivery Systems for Biomedical Applications
    Ji Wang, Haofang Zhu, Jingjing Gan, Gaofeng Liang, Ling Li, Yuanjin Zhao · 2023 · Advanced Materials
70. Lipid Nanoparticle-Based Delivery SystemA Competing Place for mRNA Vaccines
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71. Advancements and challenges in mRNA and ribonucleoprotein-based therapies: From delivery systems to clinical applications
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72. Advances and applications of RNA vaccines in tumor treatment
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73. Monitoring Translation Activity of mRNA-Loaded Nanoparticles in Mice
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74. mRNA transfection by a Xentry-protamine cell-penetrating peptide is enhanced by TLR antagonist E6446
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75. Target-Directed Approaches for Screening Small Molecules against RNA Targets
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76. Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment
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77. Current Clinical Trials Protocols and the Global Effort for Immunization against SARS-CoV-2
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78. The Novel Platform of mRNA COVID-19 Vaccines and Myocarditis: Clues into the Potential Underlying Mechanism
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79. N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
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80. Telomere Length: A Cardiovascular Biomarker and a Novel Therapeutic Target
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81. Bioinspired Lipid Nanocarriers for RNA Delivery
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82. Mechanisms and research advances in mRNA antibody drug-mediated passive immunotherapy
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83. Precision Sequence‐Defined Polymers: From Sequencing to Biological Functions
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84. Therapeutic synthetic and natural materials for immunoengineering
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85. Functionalized nanoparticles to deliver nucleic acids to the brain for the treatment of Alzheimer’s disease
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86. Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination
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87. Construction and validation of an RNA trans-splicing molecule suitable to repair a large number of COL7A1 mutations
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88. A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry
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89. Increasing lean muscle mass in mice via nanoparticle-mediated hepatic delivery of follistatin mRNA
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90. Lipid-mRNA Nanoparticle Designed to Enhance Intracellular Delivery Mediated by Shock Waves
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91. Efficient inhibition of RNA self-primed extension by addition of competing 3′-capture DNA-improved RNA synthesis by T7 RNA polymerase
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92. Nucleic acid-based therapy for coronavirus disease 2019
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93. Polymers Strive for Accuracy: From Sequence-Defined Polymers to mRNA Vaccines against COVID-19 and Polymers in Nucleic Acid Therapeutics
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94. Current strategies employed in the manipulation of gene expression for clinical purposes
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95. RNA-Targeted Therapies and High-Throughput Screening Methods
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96. Modulating the expression of tumor suppressor genes using activating oligonucleotide technologies as a therapeutic approach in cancer
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97. An engineered T7 RNA polymerase for efficient co-transcriptional capping with reduced dsRNA byproducts in mRNA synthesis
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98. Time-Resolved Inspection of Ionizable Lipid-Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Early Endosomal Membrane Mimic
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99. Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines
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100. Delivery of synthetic mRNAs for tissue regeneration
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