Transferrin' bispecific antibodies across the blood–brain barrier
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Transferrin receptor, insulin receptor, and leptin receptor mediate blood-to-brain transport of transferrin, insulin, and leptin across the blood-brain barrier, respectively.
“Transferrin receptor (TfR) (78, 290, 461), insulin receptor (IR) (283, 458), and leptin receptor (LEP-R) (41, 206, 699) mediate blood-to-brain transport of transferrin (iron-protein carrier), insulin, and leptin across the BBB, respectively.”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [78]
Cites
Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
Yu, Y. J., Atwal, J. K., Zhang, Y., Tong, R. K., Wildsmith, K. R., Tan, C., Bien-Ly, N., Hersom, M., Maloney, J. A., Meilandt, W. J., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009835 · Cited by 371 · see citing works
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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076 · see citing works
Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Establishment and Dysfunction of the Blood-Brain Barrier
Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670 · see citing works
- Authors
- Bray, N.
- Corresponding author
- Bray, Natasha
- ORCID
- Bray, Natasha
- Venue
- Nature Reviews Drug Discovery
- Published
- 2014-12-12
- Volume
- 14
- Issue
- 1
- Pages
- 14-15
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2048290149
- Cited by
- 16
- References
- 1
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- transferrin, bispecific antibodies, blood-brain barrier, non-human primates, neurotensin, neurodegeneration, brain drug delivery
- MeSH terms
- Animals, Blood-Brain Barrier, Capillary Permeability, Humans, Receptors, Transferrin, Antigens, CD, Aspartic Acid Endopeptidases, Antibodies, Bispecific, Amyloid Precursor Protein Secretases
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