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Cited by 706

The DOI matches its Crossref record; 205 of the 205 references it cites were found in a registry or an index.

Acute rheumatic fever and rheumatic heart disease

Open access
Carapetis, Jonathan R., Beaton, Andrea, Cunningham, Madeleine W., Guilherme, Luiza, Karthikeyan, Ganesan, Mayosi, Bongani M., Sable, Craig, Steer, Andrew, Wilson, Nigel, Wyber, Rosemary, Zühlke, Liesl·2016·Nature Reviews Disease Primers

Abstract

Acute rheumatic fever (ARF) is the result of an autoimmune response to pharyngitis caused by infection with group A Streptococcus. The long-term damage to cardiac valves caused by ARF, which can result from a single severe episode or from multiple recurrent episodes of the illness, is known as rheumatic heart disease (RHD) and is a notable cause of morbidity and mortality in resource-poor settings around the world. Although our understanding of disease pathogenesis has advanced in recent years, this has not led to dramatic improvements in diagnostic approaches, which are still reliant on clinical features using the Jones Criteria, or treatment practices. Indeed, penicillin has been the mainstay of treatment for decades and there is no other treatment that has been proven to alter the likelihood or the severity of RHD after an episode of ARF. Recent advances — including the use of echocardiographic diagnosis in those with ARF and in screening for early detection of RHD, progress in developing group A streptococcal vaccines and an increased focus on the lived experience of those with RHD and the need to improve quality of life — give cause for optimism that progress will be made in coming years against this neglected disease that affects populations around the world, but is a particular issue for those living in poverty.

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Crossref · 10.1038/nrdp.2015.84

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Metadata

Authors
Carapetis, J. R., Beaton, A., Cunningham, M. W., Guilherme, L., Karthikeyan, G., Mayosi, B. M., Sable, C., Steer, A., Wilson, N., Wyber, R., & Zühlke, L.
Venue
Nature Reviews Disease Primers
Published
2016-01-14
Volume
2
Issue
1
Pages
15084-15084
ISSN
2056-676X (ISSN-L)
OpenAlex
W2472620246
Cited by
706
References
205
FWCI
8.06
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Acute rheumatic fever and rheumatic heart disease. https://app.cochat.ai/papers/10.1038/nrdp.2015.84
The paper
Carapetis, J. R., Beaton, A., Cunningham, M. W., Guilherme, L., Karthikeyan, G., Mayosi, B. M., Sable, C., Steer, A., Wilson, N., Wyber, R., & Zühlke, L. (2016). Acute rheumatic fever and rheumatic heart disease. Nature Reviews Disease Primers. https://doi.org/10.1038/nrdp.2015.84

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