The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Developing and evaluating polygenic risk prediction models for stratified disease prevention
Open accessAbstract
Knowledge of genetics and its implications for human health is rapidly evolving in accordance with recent events, such as discoveries of large numbers of disease susceptibility loci from genome-wide association studies, the US Supreme Court ruling of the non-patentability of human genes, and the development of a regulatory framework for commercial genetic tests. In anticipation of the increasing relevance of genetic testing for the assessment of disease risks, this Review provides a summary of the methodologies used for building, evaluating and applying risk prediction models that include information from genetic testing and environmental risk factors. Potential applications of models for primary and secondary disease prevention are illustrated through several case studies, and future challenges and opportunities are discussed.
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Cites
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Cited by
Benefits and limitations of genome-wide association studies
Tam, V., Patel, N., Turcotte, M., Bossé, Y., Paré, G., & Meyre, D. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0127-1 · Cited by 2,092
Polygenic prediction via Bayesian regression and continuous shrinkage priors
Ge, T., Chen, C.-Y., Ni, Y., Feng, Y.-C. A., & Smoller, J. W. (2019) · Nature Communications · doi:10.1038/s41467-019-09718-5 · Cited by 1,922
The personal and clinical utility of polygenic risk scores
Torkamani, A., Wineinger, N. E., & Topol, E. J. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0018-x · Cited by 1,623
Designing Difference in Difference Studies: Best Practices for Public Health Policy Research
Wing, C., Simon, K., & Bello-Gomez, R. A. (2018) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040617-013507 · Cited by 1,470
Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations
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Metadata
- Authors
- Chatterjee, N., Shi, J., & García-Closas, M.
- Venue
- Nature Reviews Genetics
- Published
- 2016-05-03
- Volume
- 17
- Issue
- 7
- Pages
- 392-406
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2345958530
- Cited by
- 697
- References
- 110
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
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