Detecting shared pathogenesis from the shared genetics of immune-related diseases
Abstract
Recent genetic studies have revealed shared immunological mechanisms in several immune-related disorders that further our understanding of the development and concomitance of these diseases. Our Review focuses on these shared aspects, using the novel findings of recently performed genome-wide association studies and non-synonymous SNP scans as a starting point. We discuss how identifying new genes that are associated with more than one autoimmune or chronic inflammatory disorder could explain the genetic basis of the shared pathogenesis of immune-related diseases. This analysis helps to highlight the key molecular pathways that are involved in these disorders and the potential roles of novel genes in immune-related diseases.
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Autoimmune and inflammatory diseases as a group have proven remarkably tractable to genetic dissection in large cohorts, with several hundred risk loci now known in each disease.
“As a group, the autoimmune and inflammatory diseases have proven remarkably tractable to genetic dissection in large cohorts, with several hundred risk loci now known in each disease.68”
From Genome‐wide association studies of multiple sclerosis (2018) · cites this paper as [68]
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References 142 · Cited by 551
- Authors
- Zhernakova, A., van Diemen, C. C., & Wijmenga, C.
- Affiliations
- University Medical Center Utrecht (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Wijmenga, Cisca
- Venue
- Nature Reviews Genetics
- Published
- 2009-01
- Volume
- 10
- Issue
- 1
- Pages
- 43-55
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1963639770
- Cited by
- 551
- References
- 142
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 27 · 2023: 30 · 2022: 14 · 2021: 20 · 2020: 14 · 2019: 17 · 2018: 28 · 2017: 21 · 2016: 34 · 2015: 34 · 2014: 40 · 2013: 54 · 2012: 45
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- shared pathogenesis, immune-related diseases, autoimmune disease, chronic inflammatory diseases, shared genetic loci, genome-wide association study, non-synonymous SNPs, susceptibility genes, molecular pathways, therapeutic target
- MeSH terms
- Animals, Autoimmune Diseases, Autophagy, Cell Differentiation, Humans, Immunity, Innate, Models, Biological, T-Lymphocytes, Tumor Necrosis Factor-alpha, Signal Transduction, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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