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Cited by 3,449Gut microbiota and healthOral microbiology and periodontitis researchMicrobial Community Ecology and Physiology

The human microbiome: at the interface of health and disease

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Cho, Ilseung, Blaser, Martin J.·2012·Nature Reviews Genetics
DOI 10.1038/nrg3182PMC PMC3418802
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Abstract

Interest in the role of the microbiome in human health has burgeoned over the past decade with the advent of new technologies for interrogating complex microbial communities. The large-scale dynamics of the microbiome can be described by many of the tools and observations used in the study of population ecology. Deciphering the metagenome and its aggregate genetic information can also be used to understand the functional properties of the microbial community. Both the microbiome and metagenome probably have important functions in health and disease; their exploration is a frontier in human genetics.

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  • In humans, the microbiota of infants was similar to the vaginal microbiota of their mother after natural birth but mimicked the skin microbiota when caesarean section was performed.

    “In humans, studies have shown that the microbiota of infants was similar to the vaginal microbiota of their mother after natural birth but mimicked the skin microbiota when caesarean section was performed (Cho and Blaser, 2012; Ursell et al., 2012).”

    From The Active Microbiota of the Eggs and the Nauplii of the Pacific Blue Shrimp Litopenaeus stylirostris Partially Shaped by a Potential Vertical Transmission (2022) · cites this paper as Cho and Blaser, 2012

    In “Inheritance of microbiota” (page unavailable), the paper says that newborns’ founding microbes closely resemble their mother’s vaginal microbiota immediately after vaginal delivery. It also says caesarean delivery produces substantially different founding populations, but does not say those populations mimic skin microbiota. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • The gut microbiota plays a pivotal role in the regulation of metabolic, endocrine, and immune functions.

    “A substantial body of evidence supports that the gut microbiota plays a pivotal role in the regulation of metabolic, endocrine and immune functions.”

    From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [4]

    The 'Characterizing the microbiome' section describes microbial participation in host metabolism, and 'The colon microbiota and inflammatory bowel disease' section says the microbiome is essential for activating host immune responses. Our copy does not establish the claimed role in regulating endocrine functions (searched: endocrine, hormones, insulin, ghrelin and leptin). (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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References 142 · Cited by 3,449

Research works printed but not linked: 125

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Authors
Cho, I., & Blaser, M. J.
Affiliations
  • NYU Langone Health (US)
  • VA NY Harbor Healthcare System (US)
Corresponding author
Cho, Ilseung
ORCID
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2012-03-13
Volume
13
Issue
4
Pages
260-270
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
DOI
10.1038/nrg3182
PMC
PMC3418802
OpenAlex
W2147637673
Cited by
3,449
References
142
Citations by year
2026: 117 · 2025: 179 · 2024: 240 · 2023: 312 · 2022: 315 · 2021: 303 · 2020: 326 · 2019: 328 · 2018: 286 · 2017: 273 · 2016: 262 · 2015: 196 · 2014: 161 · 2013: 107 · 2012: 36
FWCI
14.58
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (P30CA016087)
  • National Institute of General Medical Sciences (R01 GM 63270, R01GM063270)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090989)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (UH2AR057506)
  • National Center for Research Resources (UL1RR029893)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords
human microbiome, microbiome and disease, metagenomics, microbial community dynamics, population ecology, microbial community composition, host-microbe interactions, human health
MeSH terms
Arthritis, Rheumatoid, Bacteria, Colon, Humans, Liver Diseases, Obesity, Inflammatory Bowel Diseases, Genomics, Gastrointestinal Tract, Metagenome

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