Promiscuity and the single receptor: NKG2D
Abstract
NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by natural killer (NK) cells and T cells that regulates immune responses during infection, cancer and autoimmunity. NKG2D ligands comprise a diverse array of MHC-class-I-related proteins that are upregulated by cellular stress. Why is it beneficial for the host to have so many ligands for the same receptor? In this Opinion article, we propose that although competition with viruses is the most likely evolutionary drive for this diversity, there might be other explanations.
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The candidate signature gene RAET1G is one of the few genes that could encode a ligand recognized by NKG2D proteins in response to stress and infections.
“Remarkably, the candidate signature gene RAET1G is one of the few genes that could encode a ligand recognized by NKG2D proteins in response to stress and infections (Eagle and Trowsdale, 2007; Tomasec et al., 2007; Lanier, 2015).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Eagle and Trowsdale, 2007
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References 98 · Cited by 374
- Authors
- Eagle, R. A., & Trowsdale, J.
- Affiliations
- University of Cambridge (GB)
- Venue
- Nature Reviews Immunology
- Published
- 2007-08-03
- Volume
- 7
- Issue
- 9
- Pages
- 737-744
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2024579897
- Cited by
- 374
- References
- 98
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 11 · 2020: 10 · 2019: 12 · 2018: 21 · 2017: 20 · 2016: 18 · 2015: 17 · 2014: 24 · 2013: 27 · 2012: 30
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Cancer Research UK
- Isaac Newton Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- NKG2D, NKG2D ligands, cellular stress response, natural killer cells, T cells, activating receptors, viral evasion, innate immunity
- MeSH terms
- Animals, Humans, Killer Cells, Natural, Ligands, Neoplasms, Receptors, Immunologic, T-Lymphocytes, Histocompatibility Antigens Class I, Mice, Receptors, Natural Killer Cell, NK Cell Lectin-Like Receptor Subfamily K
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