The 'AHR diet' for mucosal homeostasis
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Environmental differences such as diet, ligand amount in diet, bedding, caging, or facility pathogens can influence observed phenotypes in Ahr null mice.
“Differences in the environment such as diet, amount of ligand in the diet, bedding, caging, or the presence of pathogens in the facility can influence observed phenotypes.”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Leavy, 2011
Dietary ligands can influence the microbiome and AHR signaling.
“These environmental considerations are particularly important as it is now known that ligands obtained through the diet can influence microbiome and AHR signaling, and it is also likely that differences in pathogens can affect immune output in laboratory mice (Brawner et al., 2019; Leavy, 2011; Schanz et al., 2020).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Leavy, 2011
Differences in pathogens can affect immune output in laboratory mice.
“These environmental considerations are particularly important as it is now known that ligands obtained through the diet can influence microbiome and AHR signaling, and it is also likely that differences in pathogens can affect immune output in laboratory mice (Brawner et al., 2019; Leavy, 2011; Schanz et al., 2020).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Leavy, 2011
Cites
The light and dark sides of intestinal intraepithelial lymphocytes
Cheroutre, H., Lambolez, F., & Mucida, D. (2011) · Nature Reviews Immunology · doi:10.1038/nri3007 · Cited by 693 · see citing works
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Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.014 · Cited by 1,066 · see citing works
Natividad, J. M., Agus, A., Planchais, J., Lamas, B., Jarry, A. C., Martin, R., Michel, M.-L., Chong-Nguyen, C., Roussel, R., Straube, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.001 · Cited by 642 · see citing works
Albers, R., Bourdet-Sicard, R., Braun, D., Calder, P. C., Herz, U., Lambert, C., Lenoir-Wijnkoop, I., Méheust, A., Ouwehand, A., Phothirath, P., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114513001505 · Cited by 150 · see citing works
Wu, D., Su, X., Potluri, N., Kim, Y., & Rastinejad, F. (2016) · eLife · doi:10.7554/elife.18790 · Cited by 85 · see citing works
Rodent Genetic Models of Ah Receptor Signaling
Wilson, R. H., & Bradfield, C. A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1955916 · Cited by 16 · see citing works
“…considerations are particularly important as it is now known that ligands obtained through the diet can influence microbiome and AHR signaling, and it is also likely that differences in pathogens can affect immune status in laboratory mice (Leavy 2011; Brawner et al. 2019; Schanz et al. 2020).”
Background
- Authors
- Leavy, O.
- Corresponding author
- Leavy, Olive
- Venue
- Nature Reviews Immunology
- Published
- 2011-11-11
- Volume
- 11
- Issue
- 12
- Pages
- 806-806
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2015354572
- Cited by
- 13
- References
- 1
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 3 · 2014: 1 · 2013: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- aryl hydrocarbon receptor, AhR ligands, cruciferous vegetables, intestinal mucosa, mucosal homeostasis, intestinal immunity, diet and immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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