HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
Abstract
In search of foreign antigens, lymphocytes recirculate from the blood, through lymph nodes, into lymphatics and back to the blood. Dendritic cells also migrate to lymph nodes for optimal interaction with lymphocytes. This continuous trafficking of immune cells into and out of lymph nodes is essential for immune surveillance of foreign invaders. In this article, we review our current understanding of the functions of high endothelial venules (HEVs), stroma and lymphatics in the entry, positioning and exit of immune cells in lymph nodes during homeostasis, and we highlight the unexpected role of dendritic cells in the control of lymphocyte homing through HEVs.
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Lymphocytes gain access to lymph nodes from the blood through HEVs before migrating to their respective T and B cell-dependent areas in the lymph node parenchyma.
“Lymphocytes gain access to lymph nodes from the blood through HEVs before migrating to their respective T and B cell–dependent areas in the lymph node parenchyma (27, 86).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [86]
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- Authors
- Girard, J.-P., Moussion, C., & Förster, R.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Girard, Jean-Philippe
- Venue
- Nature Reviews Immunology
- Published
- 2012-09-28
- Volume
- 12
- Issue
- 11
- Pages
- 762-773
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2034750640
- Cited by
- 713
- References
- 101
- Citations by year
- 2026: 46 · 2025: 58 · 2024: 46 · 2023: 57 · 2022: 61 · 2021: 66 · 2020: 62 · 2019: 45 · 2018: 56 · 2017: 45 · 2016: 57 · 2015: 41 · 2014: 41 · 2013: 31 · 2012: 1
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Institute of Science and Technology Austria (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Fondation ARC pour la Recherche sur le Cancer
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- high endothelial venules, lymphatic vessels, lymph node stroma, immune cell trafficking, lymphocyte homing, dendritic cells, lymphocyte recirculation, immune surveillance
- MeSH terms
- Sphingosine-1-Phosphate Receptors, B-Lymphocytes, Cell Movement, Dendritic Cells, Endothelium, Lymphatic, Homeostasis, Humans, Immunologic Surveillance, Lymph Nodes, T-Lymphocytes, Venules, Receptors, Lymphocyte Homing, Receptors, Lysosphingolipid
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