How leukocytes cross the vascular endothelium
Abstract
Immune responses depend on the ability of leukocytes to move from the circulation into tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow them to cross the barrier of the blood vessel wall. This process is regulated by a concerted action between endothelial cells and leukocytes, whereby endothelial cells activate leukocytes and direct them to extravasation sites, and leukocytes in turn instruct endothelial cells to open a path for transmigration. This Review focuses on recently described mechanisms that control and open exit routes for leukocytes through the endothelial barrier.
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Paracellular diapedesis is regulated by endothelial VE-cadherin, JAM-A, ESAM, PECAM1, and CD99 and leukocyte LFA-1, PECAM1, and CD99.
“Paracellular diapedesis is regulated by endothelial VE-cadherin, JAM-A, ESAM, PECAM1, and CD99 and leukocyte LFA-1, PECAM1, and CD99 (161, 215, 617) (FIGURE 10) .”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [617]
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- Authors
- Vestweber, D.
- Affiliations
- Max Planck Institute for Molecular Biomedicine (DE)
- Corresponding author
- Vestweber, Dietmar
- ORCID
- Vestweber, Dietmar
- Venue
- Nature Reviews Immunology
- Published
- 2015-10-16
- Volume
- 15
- Issue
- 11
- Pages
- 692-704
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2175927969
- Cited by
- 858
- References
- 5
- Citations by year
- 2026: 65 · 2025: 88 · 2024: 80 · 2023: 81 · 2022: 94 · 2021: 109 · 2020: 75 · 2019: 70 · 2018: 81 · 2017: 72 · 2016: 43
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- leukocyte transmigration, leukocyte-endothelium interaction, endothelial barrier, inflammation, immune response, endothelial activation, leukocyte recruitment
- MeSH terms
- 12E7 Antigen, Animals, Cell Movement, Endothelium, Vascular, Humans, Leukocytes, Antigens, CD, Cell Adhesion Molecules, Integrins, Intercellular Adhesion Molecule-1
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