Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
Open accessAbstract
Ageing is the predominant risk factor for many common diseases. Human premature ageing diseases are powerful model systems to identify and characterize cellular mechanisms that underpin physiological ageing. Their study also leads to a better understanding of the causes, drivers and potential therapeutic strategies of common diseases associated with ageing, including neurological disorders, diabetes, cardiovascular diseases and cancer. Using the rare premature ageing disorder Hutchinson-Gilford progeria syndrome as a paradigm, we discuss here the shared mechanisms between premature ageing and ageing-associated diseases, including defects in genetic, epigenetic and metabolic pathways; mitochondrial and protein homeostasis; cell cycle; and stem cell-regenerative capacity.
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Several hereditary syndromes show common genetic bases of aging and cancer, as accelerated aging can be accompanied by precocious development of multiple malignancies.
“Moreover, several hereditary syndromes highlight the common genetic bases of aging and cancer in thus far that accelerated aging (progeria) can be accompanied by the precocious development of multiple malignancies.”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [13]
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References 151 · Cited by 320
- Authors
- Kubben, N., & Misteli, T.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Kubben, Nard
- Misteli, Tom
- ORCID
- Misteli, Tom
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2017-08-09
- Volume
- 18
- Issue
- 10
- Pages
- 595-609
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC6290461
- OpenAlex
- W2744242723
- Cited by
- 320
- References
- 151
- Citations by year
- 2026: 27 · 2025: 31 · 2024: 34 · 2023: 43 · 2022: 56 · 2021: 35 · 2020: 38 · 2019: 25 · 2018: 29 · 2017: 2
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (ZIABC010309)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- premature aging, Hutchinson-Gilford progeria syndrome, genomic instability, metabolic defects, regenerative capacity, epigenetic mechanisms, mitochondrial homeostasis, proteostasis, cell cycle, stem cells, neurological disorders, diabetes mellitus, cardiovascular disease, cancer
- MeSH terms
- Aging, Animals, DNA Repair, Humans, Progeria, Aging, Premature, Genomic Instability, Epigenesis, Genetic
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