The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease
Abstract
Protein phosphorylation regulates many cellular processes by causing changes in protein conformation. The prolyl isomerase PIN1 has been identified as a regulator of phosphorylation signalling that catalyses the conversion of specific phosphorylated motifs between the two completely distinct conformations in a subset of proteins. PIN1 regulates diverse cellular processes, including growth-signal responses, cell-cycle progression, cellular stress responses, neuronal function and immune responses. In line with the diverse physiological roles of PIN1, it has also been linked to several diseases that include cancer, Alzheimer's disease and asthma, and thus it might represent a novel therapeutic target.
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References 149 · Cited by 682
- Authors
- Lu, K. P., & Zhou, X. Z.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-11
- Volume
- 8
- Issue
- 11
- Pages
- 904-916
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2031588422
- Cited by
- 682
- References
- 149
- Citations by year
- 2026: 14 · 2025: 30 · 2024: 31 · 2023: 26 · 2022: 29 · 2021: 31 · 2020: 34 · 2019: 24 · 2018: 43 · 2017: 44 · 2016: 43 · 2015: 43 · 2014: 53 · 2013: 47 · 2012: 41
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- Pin1, peptidyl-prolyl isomerase, protein phosphorylation, protein conformation, cell cycle regulation, cellular stress response, neuronal function, immune response, cancer, Alzheimer's disease, asthma, therapeutic target
- MeSH terms
- Animals, Catalysis, Cell Cycle, Disease, Humans, Phosphorylation, Signal Transduction, Peptidylprolyl Isomerase
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