Clocks not winding down: unravelling circadian networks
Abstract
An intrinsic clock enables an organism to anticipate environmental changes and use energy sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock to orchestrate rhythms is also important for human health. The use of systems biology approaches has advanced our understanding of mechanistic features of circadian oscillators over the past decade. The field is now in a position to develop a multiscale view of circadian systems, from the molecular level to the intact organism, and to apply this information for the development of new therapeutic strategies or for enhancing agricultural productivity in crops.
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The ultradian pattern is caused by intrinsic dynamics of the HPA axis itself.
“It is generally believed that the circadian pattern is modulated by exogenous factors such as daylight, temperature, psychological as well as physical stress, but that the ultradian pattern is caused by intrinsic dynamics of the HPA axis itself [13, 19, 32, 36, 54].”
From Patient specific modeling of the HPA axis related to clinical diagnosis of depression (2017) · cites this paper as [54]
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References 113 · Cited by 446
- Authors
- Zhang, E. E., & Kay, S. A.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Kay, Steve A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-10-22
- Volume
- 11
- Issue
- 11
- Pages
- 764-776
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2015950073
- Cited by
- 446
- References
- 113
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 12 · 2023: 9 · 2022: 16 · 2021: 15 · 2020: 21 · 2019: 18 · 2018: 31 · 2017: 35 · 2016: 49 · 2015: 48 · 2014: 43 · 2013: 44 · 2012: 38
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Agency for Infrastructure Technology Advancement
- National Institute of Mental Health (R01MH051573)
- National Institute of General Medical Sciences (R01GM074868, R01 GM092412, R01GM067837, R01GM056006)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Keywords
- circadian clock, molecular clock, energy efficiency, circadian rhythm, crop productivity
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Energy Metabolism, Humans, Models, Genetic, Gene Expression Profiling, Gene Regulatory Networks, CLOCK Proteins
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