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Cited by 560Protein Kinase Regulation and GTPase SignalingCellular transport and secretionReceptor Mechanisms and Signaling

The ‘invisible hand’: Regulation of RHO GTPases by RHOGDIs

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Garcia-Mata, Rafael, Boulter, Etienne, Burridge, Keith·2011·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3153PMC PMC3260518
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Abstract

The 'invisible hand' is a term originally coined by Adam Smith in The Theory of Moral Sentiments to describe the forces of self-interest, competition and supply and demand that regulate the resources in society. This metaphor continues to be used by economists to describe the self-regulating nature of a market economy. The same metaphor can be used to describe the RHO-specific guanine nucleotide dissociation inhibitor (RHOGDI) family, which operates in the background, as an invisible hand, using similar forces to regulate the RHO GTPase cycle.

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  • GDIs prevent dissociation of GDP from the GTPase and retain inactive GDP-bound GTPases in the cytosol.

    “Inactivation is further facilitated by guanine nucleotide dissociation inhibitors (GDIs) that prevent dissociation of GDP from the GTPase and thus retain the inactive GDP-bound GTPases in the cytosol.”

    From RhoA Signaling in Neurodegenerative Diseases (2022) · cites this paper as [15]

  • Only three RhoGDIs have been described in mammals.

    “In contrast to the vast number of known RhoGEFs and RhoGAPs, only three RhoGDIs have been described in mammals [15].”

    From RhoA Signaling in Neurodegenerative Diseases (2022) · cites this paper as [15]

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Authors
Garcia-Mata, R., Boulter, E., & Burridge, K.
Affiliations
  • Inserm (FR)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Burridge, Keith
ORCID
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2011-07-22
Volume
12
Issue
8
Pages
493-504
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm3153
PMC
PMC3260518
OpenAlex
W1985617800
Cited by
560
References
2
Citations by year
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FWCI
4.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • Institut National de la Santé et de la Recherche Médicale
  • Institut National Du Cancer
  • National Institutes of Health (5r01gm029860-35, GM029860)
  • National Heart, Lung, and Blood Institute (P01HL080166, HL 080166)
  • National Institute of General Medical Sciences (R01-GM029860, GM029860)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
Rho GTPases, RhoGDI, guanine nucleotide dissociation inhibitor, protein stability, membrane localization
MeSH terms
Animals, Humans, Models, Biological, Models, Molecular, Neoplasms, Phosphorylation, Phylogeny, Molecular Chaperones, Evolution, Molecular, Guanine Nucleotide Dissociation Inhibitors, rho GTP-Binding Proteins, Membrane Microdomains, Multiprotein Complexes, Metabolic Networks and Pathways, Protein Interaction Domains and Motifs, rho-Specific Guanine Nucleotide Dissociation Inhibitors, rho Guanine Nucleotide Dissociation Inhibitor alpha

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