Mitochondria: master regulators of danger signalling
Abstract
Throughout more than 1.5 billion years of obligate endosymbiotic co-evolution, mitochondria have developed not only the capacity to control distinct molecular cascades leading to cell death but also the ability to sense (and react to) multiple situations of cellular stress, including viral infection. In addition, mitochondria can emit danger signals that alert the cell or the whole organism of perturbations in homeostasis, hence promoting the induction of cell-intrinsic or systemic adaptive responses, respectively. As such, mitochondria can be considered as master regulators of danger signalling.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dying cells can expose or release molecules (DAMPs or alarmins) that alert the organism or colony about a potential threat.
“Such a homeostatic function not only reflects the elimination of useless or potentially dangerous cells, but also the ability of dying cells to expose or release molecules that alert the organism or colony about a potential threat. Such danger signals are commonly referred to as damage-associated molecular patterns (DAMPs) or alarmins [19–22].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [21]
The citation lists haven’t been fetched yet
References 84 · Cited by 733
- Authors
- Galluzzi, L., Kepp, O., & Kroemer, G.
- Affiliations
- Université Paris Descartes (FR)
- Inserm (FR)
- Université Paris-Sud (FR)
- Corresponding author
- Kroemer, Guido
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2012-11-23
- Volume
- 13
- Issue
- 12
- Pages
- 780-788
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2167049000
- Cited by
- 733
- References
- 84
- Citations by year
- 2026: 22 · 2025: 46 · 2024: 45 · 2023: 39 · 2022: 45 · 2021: 71 · 2020: 60 · 2019: 49 · 2018: 61 · 2017: 45 · 2016: 54 · 2015: 73 · 2014: 73 · 2013: 50
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Fondation Bettencourt Schueller
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- mitochondria, mitochondrial homeostasis, viral infection, cell death, systemic immune response, adaptive immunity
- MeSH terms
- Animals, Humans, Mitochondria, Signal Transduction, Apoptosis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
