Type VII secretion — mycobacteria show the way
Abstract
Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their hydrophobic, and highly impermeable, cell wall. Strikingly, mycobacterial genomes encode up to five of these transport systems. Two of these systems, ESX-1 and ESX-5, are involved in virulence - they both affect the cell-to-cell migration of pathogenic mycobacteria. Here, we discuss this novel secretion pathway and consider variants that are present in various Gram-positive bacteria. Given the unique composition of this secretion system, and its general importance, we propose that, in line with the accepted nomenclature, it should be called type VII secretion.
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M. tuberculosis possesses five ESX/T7S systems, ESX-1 to ESX-5.
“M. tuberculosis possesses five ESX/T7S systems (ESX-1 to ESX-5) (7,8,11,16).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [8]
M. tuberculosis has general and specialized protein secretion systems, including the SecA pathway, the twin-arginine translocation pathway, and five ESX type VII secretion systems.
“This unusual cell envelope requires complex secretion systems for the export/secretion of proteins, such as those of the SecA and twin-arginine translocation pathways, as well as the specialized ESX/ T7S systems (7,8,16)”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [8]
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References 81 · Cited by 763
- Authors
- Abdallah, A. M., Gey van Pittius, N. C., DiGiuseppe Champion, P. A., Cox, J., Luirink, J., Vandenbroucke-Grauls, C. M. J. E., Appelmelk, B. J., & Bitter, W.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- University of California, San Francisco (US)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Bitter, Wilbert
- Venue
- Nature Reviews Microbiology
- Published
- 2007-11
- Volume
- 5
- Issue
- 11
- Pages
- 883-891
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2405978957
- Cited by
- 763
- References
- 81
- Citations by year
- 2026: 25 · 2025: 31 · 2024: 26 · 2023: 39 · 2022: 33 · 2021: 53 · 2020: 35 · 2019: 36 · 2018: 34 · 2017: 45 · 2016: 57 · 2015: 43 · 2014: 43 · 2013: 66 · 2012: 57
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- VU Research Portal (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- type VII secretion system, mycobacteria, ESX-1, protein secretion, bacterial cell wall, virulence, Gram-positive bacteria
- MeSH terms
- SEC Translocation Channels, SecA Proteins, Adenosine Triphosphatases, Bacterial Proteins, Mycobacterium, Protein Transport, Membrane Transport Proteins
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