The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
New insights into the formation of fungal aromatic polyketides
Open accessAbstract
Fungal aromatic polyketides constitute a large family of bioactive natural products and are synthesized by the non-reducing group of iterative polyketide synthases (PKSs). Their diverse structures arise from selective enzymatic modifications of reactive, enzyme-bound poly-β-keto intermediates. How iterative PKSs control starter unit selection, polyketide chain initiation and elongation, intermediate folding and cyclization, selective redox or modification reactions during assembly, and product release are central mechanistic questions underlying iterative catalysis. This Review highlights recent insights into these questions, with a particular focus on the biosynthetic programming of fungal aromatic polyketides, and draws comparisons with the allied biosynthetic processes in bacteria.
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Cites
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
Nierman, W. C., Pain, A., Anderson, M. J., Wortman, J. R., Kim, H. S., Arroyo, J., Berriman, M., Abe, K., Archer, D. B., Bermejo, C., et al. (2005) · Nature · doi:10.1038/nature04332 · Cited by 1,391
Pihet, M., Vandeputte, P., Tronchin, G., Renier, G., Saulnier, P., Georgeault, S., Mallet, R., Chabasse, D., Symoens, F., & Bouchara, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-177 · Cited by 253
Tsai, H.-F., Fujii, I., Watanabe, A., Wheeler, M. H., Chang, Y. C., Yasuoka, Y., Ebizuka, Y., & Kwon-Chung, K. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101998200 · Cited by 144
Cited by
Oxidative Cyclization in Natural Product Biosynthesis
Tang, M.-C., Zou, Y., Watanabe, K., Walsh, C. T., & Tang, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00478 · Cited by 425
Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules
Chooi, Y.-H., & Tang, Y. (2012) · The Journal of Organic Chemistry · doi:10.1021/jo301592k · Cited by 271
Metadata
- Authors
- Crawford, J. M., & Townsend, C. A.
- Venue
- Nature Reviews Microbiology
- Published
- 2010-11-16
- Volume
- 8
- Issue
- 12
- Pages
- 879-889
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2046083904
- Cited by
- 232
- References
- 3
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Crawford, J. M., & Townsend, C. A. (2010). New insights into the formation of fungal aromatic polyketides. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro2465
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