Mucin dynamics and enteric pathogens
Abstract
The extracellular secreted mucus and the cell surface glycocalyx prevent infection by the vast numbers of microorganisms that live in the healthy gut. Mucin glycoproteins are the major component of these barriers. In this Review, we describe the components of the secreted and cell surface mucosal barriers and the evidence that they form an effective barricade against potential pathogens. However, successful enteric pathogens have evolved strategies to circumvent these barriers. We discuss the interactions between enteric pathogens and mucins, and the mechanisms that these pathogens use to disrupt and avoid mucosal barriers. In addition, we describe dynamic alterations in the mucin barrier that are driven by host innate and adaptive immune responses to infection.
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In mammals, mucins form homooligomers via inter-molecular disulfide bonds between cysteine-rich domains at both ends of the proteins.
“In mammals, mucins form homooligomers via inter-molecular disulfide bonds between cysteine-rich domains at both ends of the proteins [24].”
From High level in vivo mucin-type glycosylation in Escherichia coli (2018) · cites this paper as [24]
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References 186 · Cited by 1,428
- Authors
- McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H.
- Affiliations
- The University of Queensland (AU)
- University of Gothenburg (SE)
- The University of Melbourne (AU)
- Corresponding author
- McGuckin, Michael A.
- Venue
- Nature Reviews Microbiology
- Published
- 2011-03-16
- Volume
- 9
- Issue
- 4
- Pages
- 265-278
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1973067432
- Cited by
- 1,428
- References
- 186
- Citations by year
- 2026: 67 · 2025: 105 · 2024: 104 · 2023: 103 · 2022: 109 · 2021: 94 · 2020: 90 · 2019: 89 · 2018: 83 · 2017: 95 · 2016: 78 · 2015: 114 · 2014: 87 · 2013: 99 · 2012: 81
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (543704)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- mucus barrier, mucin glycoproteins, enteric pathogens, host-pathogen interaction, mucosal immunity, innate immune response, adaptive immune response, commensal microorganisms
- MeSH terms
- Animals, Bacterial Infections, Gastric Mucosa, Gastrointestinal Diseases, Humans, Immunity, Innate, Intestinal Mucosa, Mucins, Mucus, Glycocalyx, Paneth Cells, Goblet Cells, Gastrointestinal Tract, Adaptive Immunity
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