“Blooming” in the gut: how dysbiosis might contribute to pathogen evolution.
Open accessAbstract
Hundreds of bacterial species make up the mammalian intestinal microbiota. Following perturbations by antibiotics, diet, immune deficiency or infection, this ecosystem can shift to a state of dysbiosis. This can involve overgrowth (blooming) of otherwise under-represented or potentially harmful bacteria (for example, pathobionts). Here, we present evidence suggesting that dysbiosis fuels horizontal gene transfer between members of this ecosystem, facilitating the transfer of virulence and antibiotic resistance genes and thereby promoting pathogen evolution.
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In an analogous situation in the wild, dietary shifts or a reduction in forage diversity can contribute to a change in gut microflora, setting up the potential for a dysbiosis and pathobiome.
“In an analogous situation in the wild, dietary shifts or a reduction in forage diversity can contribute to a change in gut microflora, setting up the potential for a dysbiosis and pathobiome (Stecher et al., 2013;Bass et al., 2019).”
From Novel Lethal Clostridial Infection in Florida Manatees (Trichechus manatus latirostris): Cause of the 2013 Unusual Mortality Event in the Indian River Lagoon (2022) · cites this paper as Stecher et al., 2013
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References 116 · Cited by 378
- Authors
- Stecher, B., Maier, L., & Hardt, W.-D.
- Affiliations
- Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie (DE)
- ETH Zurich (CH)
- Corresponding author
- Hardt, Wolf-Dietrich
- Venue
- Nature Reviews Microbiology
- Published
- 2013-03-11
- Volume
- 11
- Issue
- 4
- Pages
- 277-284
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2004413279
- Cited by
- 378
- References
- 116
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 31 · 2023: 34 · 2022: 30 · 2021: 31 · 2020: 43 · 2019: 24 · 2018: 29 · 2017: 27 · 2016: 27 · 2015: 28 · 2014: 31 · 2013: 9
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, other-oa)
- ETH Zürich Research Collection
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut dysbiosis, pathobionts, horizontal gene transfer, pathogen evolution, virulence genes, antibiotic resistance genes, gut microbiota, antibiotic perturbation, immunodeficiency, diet
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacteria, Diet, Drug Resistance, Microbial, Biological Evolution, Immunity, Intestines, Mammals, Gene Transfer, Horizontal, Virulence Factors, Gastrointestinal Tract, Metagenome
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