Integrins in synapse regulation
Abstract
Integrins are a large family of extracellular matrix (ECM) receptors. In the developing and adult brain, many integrins are present at high levels at synapses. The tetrapartite structure of synapses - which comprises presynaptic and postsynaptic neurons, the ECM and glial processes - places synaptic integrins in an excellent position to sense dynamic changes in the synaptic environment and use this information to coordinate further changes in synapse structure and function that will shape neural circuit properties. Recent developments in our understanding of the cellular and physiological roles of integrins, which range from control of neural process outgrowth and synapse formation to regulation of synaptic plasticity and memory, enable us to attempt a synthesis of synaptic integrin function.
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Integrins play a crucial role in the formation and structural dynamics of excitatory synapses.
“Previous research has shown that integrins play a crucial role in the formation and structural dynamics of excitatory synapses (Park and Goda 2016).”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Park and Goda 2016
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References 159 · Cited by 167
- Authors
- Park, Y. K., & Goda, Y.
- Affiliations
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Goda, Yukiko
- ORCID
- Goda, Yukiko
- Venue
- Nature Reviews Neuroscience
- Published
- 2016-11-04
- Volume
- 17
- Issue
- 12
- Pages
- 745-756
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2546592055
- Cited by
- 167
- References
- 159
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 20 · 2023: 20 · 2022: 26 · 2021: 18 · 2020: 12 · 2019: 18 · 2018: 17 · 2017: 9
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- synaptic regulation, extracellular matrix receptors, synaptogenesis, synaptic plasticity, memory, neural development, glial processes, neural circuit development, integrin signaling
- MeSH terms
- Animals, Extracellular Matrix, Humans, Memory, Nerve Net, Nervous System Diseases, Neuroglia, Neuronal Plasticity, Neurons, Synapses, Signal Transduction, Integrins, Neurogenesis
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