Rhythms of the hippocampal network
Open accessAbstract
The hippocampal local field potential (LFP) shows three major types of rhythms: theta, sharp wave-ripples and gamma. These rhythms are defined by their frequencies, they have behavioural correlates in several species including rats and humans, and they have been proposed to carry out distinct functions in hippocampal memory processing. However, recent findings have challenged traditional views on these behavioural functions. In this Review, I discuss our current understanding of the origins and the mnemonic functions of hippocampal theta, sharp wave-ripples and gamma rhythms on the basis of findings from rodent studies. In addition, I present an updated synthesis of their roles and interactions within the hippocampal network.
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Synchronous population activity of hippocampal neurons is regulated by the precise activity patterns of interneurons.
“While the above studies focused mostly on GABAARs in principal neurons of the hippocampus, the GABAARs on interneuronal membranes are also likely to play integral roles in learning and memory, as synchronous population activity of hippocampal neurons is regulated by the precise activity patterns of the interneurons [85].”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [85]
GABAARs on interneuronal membranes likely play integral roles in learning and memory.
“While the above studies focused mostly on GABAARs in principal neurons of the hippocampus, the GABAARs on interneuronal membranes are also likely to play integral roles in learning and memory, as synchronous population activity of hippocampal neurons is regulated by the precise activity patterns of the interneurons [85].”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [85]
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References 186 · Cited by 654
Research works printed but not linked: 1
- [39]Kamondi A Acsady L Wang XJ Buzsaki G Theta oscillations in somata and dendrites of hippocampal pyramidal cells in vivo: activity-dependent phase-precession of action potentials. Hippocampus 1998 8 244 261 9662139
- Authors
- Colgin, L. L.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Colgin, Laura Lee
- ORCID
- Colgin, Laura Lee
- Venue
- Nature reviews. Neuroscience
- Published
- 2016-03-10
- Volume
- 17
- Issue
- 4
- Pages
- 239-249
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC4890574
- OpenAlex
- W2294886124
- Cited by
- 654
- References
- 186
- Citations by year
- 2026: 49 · 2025: 73 · 2024: 66 · 2023: 66 · 2022: 77 · 2021: 65 · 2020: 62 · 2019: 67 · 2018: 67 · 2017: 52 · 2016: 8
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Institutes of Health
- Office of Naval Research
- National Institute of Mental Health (R01MH102450)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, neural oscillations, theta oscillations, sharp-wave ripples, gamma oscillations, local field potentials, memory processes, hippocampal network, rodent models
- MeSH terms
- Animals, Hippocampus, Humans, Learning, Nerve Net, Periodicity, Brain Waves
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