Stress, cognitive impairment and cell adhesion molecules
Open accessAbstract
Stress has profound effects on brain structure and function, but the underlying mechanisms are still poorly understood. Recent studies imply that neuronal cell adhesion molecules of the immunoglobulin superfamily--NCAM and L1--are important mediators of the effects of stress on the brain. Chronic stress regimes that lead to hippocampal atrophy and spatial-learning impairment in rodents simultaneously induce a pattern of changes in cell adhesion molecule expression that fits with a role for these molecules in stress-induced neuronal damage and neuroprotective mechanisms. These findings highlight cell adhesion molecules as potential therapeutic targets to treat stress-related cognitive disturbances.
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Expression of NCAM, L1, and PSA-NCAM are regulated by 21d chronic restraint stress.
“the expression of both NCAM, L1, and PSA-NCAM are regulated by 21d chronic restraint stress (Sandi, 2004)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Sandi, 2004
Neural cell adhesion molecule (NCAM) and its polysialated-NCAM (PSA-NCAM), as well as L1 are expressed in the dentate gyrus and CA3 region.
“Neural cell adhesion molecule (NCAM) and its polysialated-NCAM (PSA-NCAM), as well as L1 are expressed in the dentate gyrus and CA3 region”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Sandi, 2004
NCAM, PSA-NCAM, and L1 are expressed in the dentate gyrus and CA3 region, and their expression is regulated by 21-day chronic restraint stress.
“Neural cell adhesion molecule (NCAM) and its polysialated-NCAM (PSA-NCAM), as well as L1 are expressed in the dentate gyrus and CA3 region, and the expression of both NCAM, L1, and PSA-NCAM are regulated by 21d CRS.76”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [76]
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References 143 · Cited by 374
- Authors
- Sandi, C.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Sandi, Carmen
- ORCID
- Sandi, Carmen
- Venue
- Nature reviews. Neuroscience
- Published
- 2004-12
- Volume
- 5
- Issue
- 12
- Pages
- 917-930
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2062476270
- Cited by
- 374
- References
- 143
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 17 · 2021: 20 · 2020: 16 · 2019: 17 · 2018: 8 · 2017: 15 · 2016: 17 · 2015: 14 · 2014: 13 · 2013: 25 · 2012: 22
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- European Commission
- Ministerio de Ciencia y Tecnología
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- stress, cognitive impairment, adhesion molecules, CD56, L1, immunoglobulin superfamily, chronic stress, hippocampal atrophy, spatial learning, neuroprotection, therapeutic target
- MeSH terms
- Animals, Cognition Disorders, Glucocorticoids, Humans, Neurons, Stress, Physiological, Cell Adhesion Molecules
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