A clustered plasticity model of long-term memory engrams.
Abstract
Long-term memory and its putative synaptic correlates the late phases of both long-term potentiation and long-term depression require enhanced protein synthesis. On the basis of recent data on translation-dependent synaptic plasticity and on the supralinear effect of activation of nearby synapses on action potential generation, we propose a model for the formation of long-term memory engrams at the single neuron level. In this model, which we call clustered plasticity, local translational enhancement, along with synaptic tagging and capture, facilitates the formation of long-term memory engrams through bidirectional synaptic weight changes among synapses within a dendritic branch.
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These findings support the clustered plasticity model, which postulates that clustered synapses are more likely to participate in encoding the same information than synapses dispersed throughout the dendritic arbor.
“These findings support the clustered plasticity model, which postulates that clustered synapses are more likely to participate in encoding the same information than synapses dispersed throughout the dendritic arbor (Govindarajan et al., 2006).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Govindarajan et al., 2006
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References 107 · Cited by 355
- Authors
- Govindarajan, A., Kelleher, R. J., & Tonegawa, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Tonegawa, Susumu
- ORCID
- Tonegawa, Susumu
- Venue
- Nature reviews. Neuroscience
- Published
- 2006-07
- Volume
- 7
- Issue
- 7
- Pages
- 575-583
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1995001752
- Cited by
- 355
- References
- 107
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 24 · 2023: 19 · 2022: 7 · 2021: 20 · 2020: 12 · 2019: 16 · 2018: 26 · 2017: 22 · 2016: 23 · 2015: 17 · 2014: 25 · 2013: 15 · 2012: 18
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic tagging and capture, bidirectional synaptic plasticity, long-term potentiation, long-term depression, protein synthesis, action potential generation, single neuron model
- MeSH terms
- Animals, Humans, Memory, Neuronal Plasticity, Cluster Analysis, Neural Networks, Computer
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