How does PKMζ maintain long-term memory?
Abstract
Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase Mζ (PKMζ), a possible mechanism of memory storage has been identified. Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hif-1α and Hif-2α can have redundant, unique, or antagonistic functions in different contexts.
“in different contexts, these transcriptional regulators can have redundant, unique, or antagonistic functions [52].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [52]
The citation lists haven’t been fetched yet
References 60 · Cited by 431
- Authors
- Sacktor, T. C.
- Affiliations
- State University of New York (US)
- Corresponding author
- Sacktor, Todd C.
- ORCID
- Sacktor, Todd C.
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-12-01
- Volume
- 12
- Issue
- 1
- Pages
- 9-15
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2073338028
- Cited by
- 431
- References
- 60
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 15 · 2023: 10 · 2022: 17 · 2021: 10 · 2020: 23 · 2019: 38 · 2018: 26 · 2017: 30 · 2016: 34 · 2015: 33 · 2014: 33 · 2013: 55 · 2012: 48
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R01 MH53576, MH57068)
- National Institute of Mental Health (MH 57068, R01MH53576, R01MH053576)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- PKM, long-term memory, memory storage, PKC isoforms, long-term potentiation, synaptic protein localization, memory consolidation
- MeSH terms
- Animals, Enzyme Activation, Humans, Protein Kinase C, Synapses, Memory, Long-Term
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
