From the stochasticity of molecular processes to the variability of synaptic transmission
Abstract
The variability of the postsynaptic response following a single action potential arises from two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to neurotransmitter release has variable timing and amplitude. At individual synapses, the number of molecules of a given type that are involved in these processes is small enough that the stochastic (random) properties of molecular events cannot be neglected. How the stochasticity of molecular processes contributes to the variability of synaptic transmission, its sensitivity and its robustness to molecular fluctuations has important implications for our understanding of the mechanistic basis of synaptic transmission and of synaptic plasticity.
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Irregular neuronal firing can arise from fluctuating patterns of synaptic activity.
“First, it can arise from fluctuating patterns of synaptic activity [68, 69].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [69]
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References 160 · Cited by 198
- Authors
- Ribrault, C., Sekimoto, K., & Triller, A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Triller, Antoine
- Venue
- Nature Reviews Neuroscience
- Published
- 2011-06-20
- Volume
- 12
- Issue
- 7
- Pages
- 375-387
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1993186676
- Cited by
- 198
- References
- 160
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 6 · 2023: 15 · 2022: 11 · 2021: 14 · 2020: 5 · 2019: 13 · 2018: 15 · 2017: 23 · 2016: 16 · 2015: 20 · 2014: 20 · 2013: 11 · 2012: 8
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondation pour la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › stochastic dynamics and bifurcation
- Keywords
- synaptic transmission, randomness, molecular fluctuations, neurotransmitter release, synaptic plasticity, diffusion
- MeSH terms
- Animals, Models, Neurological, Synaptic Transmission, Neurons, Receptors, Cell Surface, Stochastic Processes, Synapses, Time Factors, Calcium Channels, Presynaptic Terminals, Neurotransmitter Agents
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