The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease
Open accessAbstract
Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal-dominant polycystic kidney disease (ADPKD). Hypertension is a common early symptom of ADPKD, and occurs in approximately 60% of patients before renal function has become impaired. Hypertension is associated with an increased rate of progression to end-stage renal disease and is the most important potentially treatable variable in ADPKD. Left ventricular hypertrophy, which is a powerful, independent risk factor for cardiovascular morbidity and mortality, also occurs frequently in patients with ADPKD. Both hypertension and left ventricular hypertrophy have important roles in cardiovascular complications in these individuals. Moreover, biventricular diastolic dysfunction, endothelial dysfunction, increased carotid intima–media thickness, and impaired coronary flow velocity reserve are present even in young patients with ADPKD who have normal blood pressure and well-preserved renal function. These findings suggest that cardiovascular involvement starts very early in the course of ADPKD. Intracranial and extracranial aneurysms and cardiac valvular defects are other potential cardiovascular problems in patients with ADPKD. Early diagnosis and treatment of hypertension, with drugs that block the renin–angiotensin–aldosterone system, has the potential to decrease the cardiovascular complications and slow the progression of renal disease in ADPKD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Koren, M. J., Devereux, R. B., Casale, P. N., Savage, D. D., & Laragh, J. H. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-5-345 · Cited by 2,366
Maschio, G., Alberti, D., Janin, G., Locatelli, F., Mann, J. F. E., Motolese, M., Ponticelli, C., Ritz, E., & Zucchelli, P. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341502 · Cited by 1,766
Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension.
Verdecchia, P., Schillaci, G., Guerrieri, M., Gatteschi, C., Benemio, G., Boldrini, F., & Porcellati, C. (1990) · Circulation · doi:10.1161/01.cir.81.2.528 · Cited by 1,224
Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease
Gabow, P. A., Johnson, A. M., Kaehny, W. D., Kimberling, W. J., Lezotte, D. C., Duley, I. T., & Jones, R. H. (1992) · Kidney International · doi:10.1038/ki.1992.195 · Cited by 509
The Renin–Angiotensin–Aldosterone System and Autosomal Dominant Polycystic Kidney Disease
Chapman, A. B., Johnson, A., Gabow, P. A., & Schrier, R. W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010183231602 · Cited by 398
Self-citationDiseases of the kidney and urinary tract
Schrier, R. W. (2001) · Cited by 396
Self-citationCauses of death in autosomal dominant polycystic kidney disease.
Fick, G. M., Johnson, A. M., Hammond, W. S., & Gabow, P. A. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v5122048 · Cited by 342
Lembo, G., Napoli, R., Capaldo, B., Rendina, V, Iaccarino, G., Volpe, M., Trimarco, B., & Saccà, L. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115842 · Cited by 252
Klahr, S., Breyer, J. A., Beck, G. J., Dennis, V. W., Hartman, J. A., Roth, D., Steinman, T. I., Wang, S. R., & Yamamoto, M. E. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v5122037 · Cited by 251
Sympathetic Activity Is Increased in Polycystic Kidney Disease and Is Associated with Hypertension
KLEIN, I. H. H. T., LIGTENBERG, G., OEY, P. L., KOOMANS, H. A., & BLANKESTIJN, P. J. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v12112427 · Cited by 248
Cited by
Kou, P., Wei, S., & Xiong, F. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867325666180330094434 · Cited by 6
Metadata
- Authors
- Ecder, T., & Schrier, R. W.
- Venue
- Nature Reviews Nephrology
- Published
- 2009-04
- Volume
- 5
- Issue
- 4
- Pages
- 221-228
- ISSN
- 1745-8323 (ISSN-L)
- 1759-5061
- 1759-507X
- OpenAlex
- W2030927065
- Cited by
- 275
- References
- 74
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease. https://app.cochat.ai/papers/10.1038/nrneph.2009.13
- The paper
- Ecder, T., & Schrier, R. W. (2009). Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease. Nature Reviews Nephrology. https://doi.org/10.1038/nrneph.2009.13
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
