The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Electrical brain stimulation for epilepsy
Abstract
Neurostimulation enables adjustable and reversible modulation of disease symptoms, including those of epilepsy. Two types of brain neuromodulation, comprising anterior thalamic deep brain stimulation and responsive neurostimulation at seizure foci, are supported by Class I evidence of effectiveness, and many other sites in the brain have been targeted in small trials of neurostimulation therapy for seizures. Animal studies have mainly assisted in the identification of potential neurostimulation sites and parameters, but much of the clinical work is only loosely based on fundamental principles derived from the laboratory, and the mechanisms by which brain neurostimulation reduces seizures remain poorly understood. The benefits of stimulation tend to increase over time, with maximal effect seen typically 1-2 years after implantation. Typical reductions of seizure frequency are approximately 40% acutely, and 50-69% after several years. Seizure intensity might also be reduced. Complications from brain neurostimulation are mainly associated with the implantation procedure and hardware, including stimulation-related paraesthesias, stimulation-site infections, electrode mistargeting and, in some patients, triggered seizures or even status epilepticus. Further preclinical and clinical experience with brain stimulation surgery should lead to improved outcomes by increasing our understanding of the optimal surgical candidates, sites and parameters.
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“They have shown significant efficacy in improving the quality of life for those suffering from a range of conditions, including but not limited to Parkinson’s disease, ALS (Willett et al., 2023), movement disorders, epilepsy, and mental health issues (Fisher and Velasco, 2014; Bergfeld et al., 2016; França et al., 2022).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Fisher and Velasco, 2014
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Cites
Rossi, S., Hallett, M., Rossini, P. M., & Pascual-Leone, A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.016 · Cited by 5,367
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
Fisher, R. S., Salanova, V., Witt, T. C., Worth, R. M., Henry, T. R., Gross, R. E., Oommen, K. J., Osorio, I., Nazzaro, J. M., Labar, D., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02536.x · Cited by 1,930
Self-citationEffect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation
Limousin, P., Pollak, P., Benazzouz, A., Hoffmann, D., Bas, J. L., Perret, J., Benabid, A., & Broussolle, E. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90062-4 · Cited by 1,480
Responsive cortical stimulation for the treatment of medically intractable partial epilepsy
Morrell, M. J. (2011) · Neurology · doi:10.1212/wnl.0b013e3182302056 · Cited by 1,282
MACLEAN, P. D. (1949) · Psychosomatic Medicine · doi:10.1097/00006842-194911000-00003 · Cited by 1,203
Jasper's Basic Mechanisms of the Epilepsies
(2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.001.0001 · Cited by 1,161
Vagus nerve stimulation therapy for partial-onset seizures
Handforth, A., DeGiorgio, C. M., Schachter, S. C., Uthman, B. M., Naritoku, D. K., Tecoma, E. S., Henry, T. R., Collins, S. D., Vaughn, B. V., Gilmartin, R. C., et al. (1998) · Neurology · doi:10.1212/wnl.51.1.48 · Cited by 1,107
Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy
Morris, G. L., Mueller, W. M., & The Vagus Nerve Stimulation Study Group E–E (1999) · Neurology · doi:10.1212/wnl.53.8.1731 · Cited by 727
Chronic Anterior Thalamus Stimulation for Intractable Epilepsy
Hodaie, M., Wennberg, R. A., Dostrovsky, J. O., & Lozano, A. M. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.26001.x · Cited by 605
Evidence-based guideline update: Vagus nerve stimulation for the treatment of epilepsy
Morris, G. L., Gloss, D. S., Buchhalter, J., Mack, K. J., Nickels, K. C., & Harden, C. L. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a393d1 · Cited by 450
Research works printed but not linked: 4
- Sussman, N. et al. Anterior thalamic stimulation in medically intractable epilepsy. Part II. preliminary clinical results. Epilepsia 29, 677 (1988).
- Salanova, V. et al. Long term efficacy of the SANTE trial (Stimulation of the Anterior Nucleus of Thalamus for Epilepsy). Epilepsy Curr. 13 (Suppl. 1), 123 (2012).
- Velasco, A., Vazquez, D. & Velasco, F. Open-loop chronic electrical stimulation (CHES) of epileptic foci localized in primary and supplementary motor cortices with nonlesional MRI. Epilepsia 54 (Suppl. 6), 112 (2013).
- Morrell, M. et al. Long-term safety and efficacy of responsive brain stimulation in adults with medically intractable partial onset seizures. Epilepsy Curr. 14 (Suppl. 1), 467–468 (2013).
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Items 401–402 of 402
Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms
Rabuffo, G., Bandyopadhyay, A., Calabrese, C., Gudibanda, K., Depannemaecker, D., Takarabe, L. M., Chatterjee, S., Saggio, M. L., Desroches, M., Ivanov, A., et al. (2026) · eLife · doi:10.7554/elife.104249.3
Neuro-immune interactions in tumors, immune-related disorders, and infections
Zhuang, Q.-Y., Zhang, S.-W., Shao, Z., Xiao, Y., & Jiang, Y. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02842-x
Metadata
- Authors
- Fisher, R. S., & Velasco, A. L.
- Affiliations
- Stanford Medicine (US)
- Hospital General de México (MX)
- Corresponding author
- Fisher, Robert S.
- Venue
- Nature Reviews Neurology
- Published
- 2014-04-08
- Volume
- 10
- Issue
- 5
- Pages
- 261-270
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2080438790
- Cited by
- 402
- References
- 118
- Citations by year
- 2026: 23 · 2025: 44 · 2024: 36 · 2023: 29 · 2022: 36 · 2021: 28 · 2020: 35 · 2019: 45 · 2018: 24 · 2017: 29 · 2016: 34 · 2015: 30 · 2014: 9
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS44601-01)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- deep brain stimulation, epilepsy, responsive neurostimulation, anterior thalamic nuclei, seizure foci, electrical neuromodulation, seizure frequency reduction, stimulation parameters, implantation complications, status epilepticus, surgical candidates, animal models of epilepsy
- MeSH terms
- Brain, Epilepsy, Humans, Deep Brain Stimulation
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