The tension between early diagnosis and misdiagnosis of multiple sclerosis
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Missing a diagnosis of MS is no longer without prognostic consequence with newer disease modifying agents.
“Whereas in the past, missing a diagnosis of MS could have been said not to have led to a change in prognosis, that is no longer the case with newer disease modifying agents [57].”
From Functional neurological disorder and multiple sclerosis: a systematic review of misdiagnosis and clinical overlap (2022) · cites this paper as [57]
The applicability of the 2010 McDonald Criteria has been reported in patients from Canada, Italy, the Netherlands, Spain, and Russia.
“The applicability of the 2010 McDonald Criteria has been reported in patients from Canada, 17 Italy, 18 the Netherlands, 19 Spain, 20 and Russia. 21”
From Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria (2018) · cites this paper as [19]
Cites
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22366 · Cited by 9,802 · see citing works
Defining the clinical course of multiple sclerosis: The 2013 revisions
Lublin, F. D., Reingold, S. C., Cohen, J. A., Cutter, G. R., Sørensen, P. S., Thompson, A. J., Wolinsky, J. S., Balcer, L. J., Banwell, B., Barkhof, F., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000560 · Cited by 3,177 · see citing works
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
Perrin, R. J., Fagan, A. M., & Holtzman, D. M. (2009) · Nature · doi:10.1038/nature08538 · Cited by 702 · see citing works
The contemporary spectrum of multiple sclerosis misdiagnosis
Solomon, A. J., Bourdette, D. N., Cross, A. H., Applebee, A., Skidd, P. M., Howard, D. B., Spain, R. I., Cameron, M. H., Kim, E., Mass, M. K., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003152 · Cited by 334 · see citing works
Self-citation
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Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167 · see citing works
Walzl, D., Solomon, A. J., & Stone, J. (2022) · Journal of Neurology · doi:10.1007/s00415-021-10436-6 · Cited by 62 · see citing works
Self-citation
- Authors
- Solomon, A. J., & Corboy, J. R.
- Affiliations
- University of Vermont (US)
- Denver VA Medical Center (US)
- Corresponding author
- Solomon, Andrew J.
- Venue
- Nature Reviews Neurology
- Published
- 2017-08-11
- Volume
- 13
- Issue
- 9
- Pages
- 567-572
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2742189301
- Cited by
- 89
- References
- 4
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 9 · 2021: 17 · 2020: 18 · 2019: 12 · 2018: 6 · 2017: 3
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- multiple sclerosis, misdiagnosis, early diagnosis, diagnostic criteria, disease-modifying therapy, treatment initiation timing, disability risk, brain MRI abnormalities, diagnostic assessment
- MeSH terms
- Diagnostic Errors, Humans, Immunologic Factors, Multiple Sclerosis, Early Diagnosis, Early Medical Intervention
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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