APOE ε4 affects cognitive decline but does not block benefits of healthy lifestyle
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The two-year FINGER trial combined diet, exercise, cognitive training, and management of metabolic and vascular risks; it reported cognitive benefits even in apoE4 carriers.
“Positive effects on cognition were reported108,110 even in subjects with the apoE4 allele110.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [110]
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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954 · see citing works
- Authors
- Fyfe, I.
- Corresponding author
- Fyfe, Ian
- ORCID
- Fyfe, Ian
- Venue
- Nature Reviews Neurology
- Published
- 2018-02-09
- Volume
- 14
- Issue
- 3
- Pages
- 125-125
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2786663017
- Cited by
- 6
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- APOE ε4, apolipoprotein E, cognitive decline, Alzheimer's disease, preclinical Alzheimer's disease, amyloid, memory decline, healthy lifestyle, dementia risk, genetic susceptibility, lifestyle intervention, disease trajectories
- MeSH terms
- Healthy Lifestyle, Alzheimer Disease, Humans, Memory Disorders, Neuropsychological Tests, Apolipoprotein E4, Cognitive Dysfunction
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