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The SAM domain of polyhomeotic forms a helical polymer.
Abstract
The polycomb group (PcG) proteins are important in the maintenance of stable repression patterns during development. Several PcG members contain a protein protein interaction module called a SAM domain (also known as SPM, PNT and HLH). Here we report the high-resolution structure of the SAM domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The structure of the polymer resembles that formed by the SAM domain of another transcriptional repressor, TEL. The formation of these polymer structures by SAM domains in two divergent repressors suggests a conserved mode of repression involving a higher order chromatin structure.
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Cites
Serra‐Pagès, C., Kedersha, N. L., Fazikas, L., Medley, Q., Debant, A., & Streuli, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07282.x · Cited by 321
Potter, M. D., Buijs, A., Kreider, B., van Rompaey, L., & Grosveld, G. C. (2000) · Blood · doi:10.1182/blood.v95.11.3341 · Cited by 79
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Stathopulos, P. B., Zheng, L., Li, G.-Y., Plevin, M. J., & Ikura, M. (2008) · Cell · doi:10.1016/j.cell.2008.08.006 · Cited by 469
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Blackledge, N. P., Rose, N. R., & Klose, R. J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4067 · Cited by 361
SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene Silencing
Isono, K., Endo, T. A., Ku, M., Yamada, D., Suzuki, R., Sharif, J., Ishikura, T., Toyoda, T., Bernstein, B. E., & Koseki, H. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.016 · Cited by 309
SAM domains: uniform structure, diversity of function
Kim, C. (2003) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2003.11.001 · Cited by 259
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Metadata
- Authors
- Kim, C. A., Gingery, M., Pilpa, R. M., & Bowie, J. U.
- Venue
- PubMed
- Publisher
- National Institutes of Health
- Published
- 2002-06-01
- Volume
- 9
- Issue
- 6
- Pages
- 453-7
- OpenAlex
- W1574290520
- Cited by
- 209
- References
- 2
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, C. A., Gingery, M., Pilpa, R. M., & Bowie, J. U. (2002). The SAM domain of polyhomeotic forms a helical polymer. PubMed. https://doi.org/10.1038/nsb802
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
