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The ClC-0 chloride channel is a 'broken' Cl−/H+ antiporter

Lísal, Jiří, Maduke, Merritt·2008·Nature Structural & Molecular Biology

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Research works printed but not linked: 31

  1. Jentsch, T.J., Poet, M., Fuhrmann, J.C. & Zdebik, A.A. Physiological functions of CLC Cl− channels gleaned from human genetic disease and mouse models. Annu. Rev. Physiol. 67, 779–807 (2005). · DOI
  2. Puljak, L. & Kilic, G. Emerging roles of chloride channels in human diseases. Biochim. Biophys. Acta 1762, 404–413 (2006). · DOI
  3. Sile, S., Vanoye, C.G. & George, A.L. Jr. Molecular physiology of renal ClC chloride channels/transporters. Curr. Opin. Nephrol. Hypertens. 15, 511–516 (2006). · DOI
  4. Stein, W.D. Carriers and Pumps. An Introduction to Membrane Transport (Academic, San Diego, CA, 1990).
  5. Chen, M.F. & Chen, T.Y. Different fast-gate regulation by external Cl− and H+ of the muscle-type ClC chloride channels. J. Gen. Physiol. 118, 23–32 (2001). · DOI
  6. Hanke, W. & Miller, C. Single chloride channels from Torpedo electroplax. Activation by protons. J. Gen. Physiol. 82, 25–45 (1983). · DOI
  7. Miller, C. ClC chloride channels viewed through a transporter lens. Nature 440, 484–489 (2006). · DOI
  8. Chen, T.Y. Structure and function of CLC channels. Annu. Rev. Physiol. 67, 809–839 (2005). · DOI
  9. Dutzler, R. The ClC family of chloride channels and transporters. Curr. Opin. Struct. Biol. 16, 439–446 (2006). · DOI
  10. Matulef, K. & Maduke, M. The CLC 'chloride channel' family: revelations from prokaryotes. Mol. Membr. Biol. 24, 342–350 (2007). · DOI
  11. Richard, E.A. & Miller, C. Steady-state coupling of ion-channel conformations to a transmembrane ion gradient. Science 247, 1208–1210 (1990). · DOI
  12. Hill, T.L. Free Energy Transduction in Biology (Academic, New York, NY, 1977).
  13. Accardi, A. & Miller, C. Secondary active transport mediated by a prokaryotic homologue of ClC Cl− channels. Nature 427, 803–807 (2004). · DOI
  14. Picollo, A. & Pusch, M. Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5. Nature 436, 420–423 (2005). · DOI
  15. Scheel, O., Zdebik, A.A., Lourdel, S. & Jentsch, T.J. Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature 436, 424–427 (2005). · DOI
  16. Traverso, S., Zifarelli, G., Aiello, R. & Pusch, M. Proton sensing of ClC-0 mutant E166D. J. Gen. Physiol. 127, 51–65 (2006). · DOI
  17. Dutzler, R., Campbell, E.B. & MacKinnon, R. Gating the selectivity filter in ClC chloride channels. Science 300, 108–112 (2003). · DOI · Paper page
  18. Chen, M.F. & Chen, T.Y. Side-chain charge effects and conductance determinants in the pore of ClC-0 chloride channels. J. Gen. Physiol. 122, 133–145 (2003). · DOI
  19. Engh, A.M. & Maduke, M. Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule. J. Gen. Physiol. 125, 601–617 (2005). · DOI
  20. Estevez, R. et al. Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron 38, 47–59 (2003). · DOI
  21. Accardi, A. et al. Separate ion pathways in a Cl−/H+ exchanger. J. Gen. Physiol. 126, 563–570 (2005). · DOI
  22. Saviane, C., Conti, F. & Pusch, M. The muscle chloride channel ClC-1 has a double-barreled appearance that is differentially affected in dominant and recessive myotonia. J. Gen. Physiol. 113, 457–468 (1999). · DOI
  23. Accardi, A. & Pusch, M. Fast and slow gating relaxations in the muscle chloride channel CLC-1. J. Gen. Physiol. 116, 433–444 (2000). · DOI
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  25. Nguitragool, W. & Miller, C. Inaugural article: CLC Cl−/H+ transporters constrained by covalent cross-linking. Proc. Natl. Acad. Sci. USA 104, 20659–20665 (2007). · DOI
  26. Zdebik, A.A. et al. Determinants of anion-proton coupling in mammalian endosomal CLC proteins. J. Biol. Chem. 283, 4219–4227 (2007). · DOI
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  30. Aromataris, E.C. & Rychkov, G.Y. ClC-1 chloride channel: matching its properties to a role in skeletal muscle. Clin. Exp. Pharmacol. Physiol. 33, 1118–1123 (2006). · DOI
  31. Jentsch, T.J., Steinmeyer, K. & Schwarz, G. Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature 348, 510–514 (1990). · DOI

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Metadata

Authors
Lísal, J., & Maduke, M.
Venue
Nature Structural & Molecular Biology
Published
2008-07-20
Volume
15
Issue
8
Pages
805-810
ISSN
  • 1545-9993
  • 1545-9985
Cited by
100
References
0
Language
en

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